Production Method 1

1215071-23-0

939398-48-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  1 h, rt

Reference

Substituted aminopurine compounds as kinase inhibitors and their compositions and preparation

, United States, , ,

Production Method 2

1260897-05-9

939398-48-8

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Sodium azide Solvents: Chloroform ,  Water ;  rt → 50 °C; 3 h, 50 °C; 3 h, 45 - 50 °C; 50 °C → rt; 48 h, rt; cooled
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 12 - 13
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified

Reference

Synthesis of gem-difluorocyclopentane/hexane building blocks

Melnykov, Kostiantyn P.; Nosik, Pavel S.; Kurpil, Bohdan B.; Sibgatulin, Dmitriy A.; Volochnyuk, Dmitriy M.; et al, Journal of Fluorine Chemistry, 2017, 199, 60-66

Production Method 3

939398-48-8

Reaction Conditions

Reference

Preparation of heterocyclic and aromatic ureas and amides as CEPT inhibitors

, United States, , ,

Production Method 4

939385-02-1

939398-48-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, 1 atm, rt
1.2 Reagents: Hydrochloric acid Solvents: Methanol ;  20 min, rt

Reference

Preparation of heterocycles as isocitrate dehydrogenase 1 inhibitors, therapeutically active compositions and their methods of use

, World Intellectual Property Organization, , ,

Production Method 5

939385-02-1

939398-48-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  20 h, 100 °C; 100 °C → rt

Reference

Preparation of heterocyclic and aromatic ureas and amides as CEPT inhibitors

, World Intellectual Property Organization, , ,

Production Method 6

939385-02-1

939398-48-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane

Reference

Compound as CDK kinase inhibitor and use thereof

, World Intellectual Property Organization, , ,

3,3-difluorocyclopentan-1-amine hydrochloride Raw materials

• tert-butyl N-(3,3-difluorocyclopentyl)carbamate
• 3,3-difluorocyclopentane-1-carboxylic acid
• benzyl3,3-difluorocyclopentylcarbamate

3,3-difluorocyclopentan-1-amine hydrochloride Preparation Products

• 3,3-difluorocyclopentan-1-amine hydrochloride (939398-48-8)

• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792

• 921753-34-6(3,3-difluorocyclohexan-1-amine)
• 1408148-48-0((1S)-3,3-difluorocyclopentan-1-amine hydrochloride)
• 2199141-40-5((1R)-3,3-Difluorocyclohexanamine;hydrochloride)
• 2309467-49-8(3,3-Difluorocycloheptan-1-amine;hydrochloride)
• 1118245-88-7(Cyclopentanamine, 3,3-difluoro-, (1R)-)
• 2199497-63-5((1S)-3,3-difluorocyclohexanamine;hydrochloride)
• 1461708-43-9(4,4-Difluorocycloheptan-1-amine)
• 921602-77-9(3,3-difluorocyclohexan-1-amine hydrochloride)
• 1117936-64-7((1R)-3,3-difluorocyclopentan-1-amine hydrochloride)
• 939525-61-8(3,3-difluorocyclopentan-1-amine)