Production Method 1

921602-76-8

921602-77-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, rt

Reference

Preparation of heterocycles as isocitrate dehydrogenase 1 inhibitors, therapeutically active compositions and their methods of use

, World Intellectual Property Organization, , ,

Production Method 2

921602-76-8

921602-77-9

Reaction Conditions

1.1 Reagents: Formic acid Catalysts: Palladium Solvents: Methanol ;  rt
1.2 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane

Reference

Preparation of triazaspirodecenones as β-secretase inhibitors for the treatment of Alzheimer's disease.

, World Intellectual Property Organization, , ,

Production Method 3

849669-20-1

921602-77-9

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Sodium azide Solvents: Chloroform ,  Water ;  rt → 50 °C; 3 h, 50 °C; 3 h, 45 - 50 °C; 50 °C → rt; 48 h, rt; cooled
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 12 - 13
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified

Reference

Synthesis of gem-difluorocyclopentane/hexane building blocks

Melnykov, Kostiantyn P.; Nosik, Pavel S.; Kurpil, Bohdan B.; Sibgatulin, Dmitriy A.; Volochnyuk, Dmitriy M.; et al, Journal of Fluorine Chemistry, 2017, 199, 60-66

3,3-difluorocyclohexan-1-amine hydrochloride Raw materials

• 3,3-difluorocyclohexane-1-carboxylic acid
• Benzyl (3,3-difluorocyclohexyl)carbamate

3,3-difluorocyclohexan-1-amine hydrochloride Preparation Products

• 3,3-difluorocyclohexan-1-amine hydrochloride (921602-77-9)

• 1. An anti-leakage liquid metal thermal interface material
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• 2. Aggregation dynamics, structure, and mechanical properties of bigels
  L. Di Michele,D. Fiocco,F. Varrato,E. Eiser,G. Foffi Soft Matter, 2014,10, 3633-3648
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• 4. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993
• 5. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159

• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Alkyl halides Cyclohexyl halides

• 675112-70-6(4,4-difluorocyclohexan-1-amine hydrochloride)
• 921753-34-6(3,3-difluorocyclohexan-1-amine)
• 458566-84-2(4,4-difluorocyclohexanamine)
• 939398-48-8(3,3-difluorocyclopentan-1-amine hydrochloride)
• 1408148-48-0((1S)-3,3-difluorocyclopentan-1-amine hydrochloride)
• 2309467-49-8(3,3-Difluorocycloheptan-1-amine;hydrochloride)
• 1118245-88-7(Cyclopentanamine, 3,3-difluoro-, (1R)-)
• 1117936-64-7((1R)-3,3-difluorocyclopentan-1-amine hydrochloride)
• 637031-93-7(3,3-difluorocyclobutan-1-amine hydrochloride)
• 939525-61-8(3,3-difluorocyclopentan-1-amine)