Cas no 938462-29-4 ((S)-2-Amino-3-(3-fluorophenyl)propan-1-ol)

(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol is a chiral amino alcohol derivative featuring a fluorinated aromatic ring, which enhances its utility in asymmetric synthesis and pharmaceutical applications. The presence of both amino and hydroxyl functional groups allows for versatile reactivity, making it a valuable intermediate in the preparation of biologically active compounds. The fluorine substitution at the meta position of the phenyl ring can influence electronic and steric properties, potentially improving metabolic stability and binding affinity in drug design. This compound is particularly useful in the synthesis of β-adrenergic receptor ligands and other fluorinated pharmacophores. Its high enantiomeric purity ensures consistent performance in stereoselective reactions.

(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol structure

938462-29-4 structure

Product Name:(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol

CAS No:938462-29-4

MF:C₉H₁₂FNO

MW:169.196085929871

MDL:MFCD17214664

CID:1981972

PubChem ID:46911825

Update Time:2025-05-24

(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol Chemical and Physical Properties

Names and Identifiers

- (S)-2-Amino-3-(3-fluorophenyl)propan-1-ol
- (2S)-2-amino-3-(3-fluorophenyl)propan-1-ol
- N11310
- AKOS015891090
- (S)-b-Amino-3-fluorobenzenepropanol
- ZALRUTRFOXROOU-VIFPVBQESA-N
- 938462-29-4
- MFCD17214664
- SCHEMBL5230112
- MDL： MFCD17214664
- Inchi： 1S/C9H12FNO/c10-8-3-1-2-7(4-8)5-9(11)6-12/h1-4,9,12H,5-6,11H2/t9-/m0/s1
- InChI Key： ZALRUTRFOXROOU-VIFPVBQESA-N
- SMILES： FC1=CC=CC(=C1)C[C@@H](CO)N

Computed Properties

Exact Mass: 169.090292168g/mol
Monoisotopic Mass: 169.090292168g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 12
Rotatable Bond Count: 3
Complexity: 132
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 0.7
Topological Polar Surface Area: 46.2

(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol Pricemore >>

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(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:938462-29-4)(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol

Order Number:A1231902

Stock Status:in Stock

Quantity:1g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 18:38

Price ($):346

Email:[email protected]

Product Official Link

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Additional information on (S)-2-Amino-3-(3-fluorophenyl)propan-1-ol

Comprehensive Overview of (S)-2-Amino-3-(3-fluorophenyl)propan-1-ol (CAS No. 938462-29-4): Properties, Applications, and Research Insights

(S)-2-Amino-3-(3-fluorophenyl)propan-1-ol, identified by its CAS number 938462-29-4, is a chiral organic compound featuring a fluorinated phenyl group and an amino alcohol moiety. This structurally unique molecule has garnered significant attention in pharmaceutical and biochemical research due to its potential as a building block for drug discovery. The fluorine substitution at the 3-position of the phenyl ring enhances its metabolic stability and binding affinity, making it valuable for designing targeted therapeutics.

Recent studies highlight the growing demand for fluorinated amino alcohols like (S)-2-Amino-3-(3-fluorophenyl)propan-1-ol in developing central nervous system (CNS) agents and enzyme inhibitors. Researchers are particularly interested in its role as a precursor for chiral ligands in asymmetric synthesis, where its stereospecificity improves reaction yields. The compound's logP value and hydrogen-bonding capacity also make it suitable for optimizing blood-brain barrier permeability—a hot topic in neurodegenerative disease research.

From a synthetic chemistry perspective, CAS 938462-29-4 is often synthesized via stereoselective reduction of corresponding keto intermediates or through enzymatic resolution methods. Its crystalline form exhibits stability under standard storage conditions, though precautions against moisture are recommended. Analytical techniques like HPLC and chiral chromatography are critical for verifying its enantiomeric purity, a key quality parameter for regulatory compliance.

The compound's applications extend to peptide mimetics and small-molecule probes for studying protein-protein interactions. With the rise of AI-driven drug design, molecular derivatives of (S)-2-Amino-3-(3-fluorophenyl)propan-1-ol are being virtually screened against GPCR targets—a trend reflected in recent PubMed publications. Environmental considerations are also addressed through green chemistry approaches in its synthesis, aligning with the industry's shift toward sustainable manufacturing.

For researchers sourcing this material, specifications such as ≥98% chemical purity and optical rotation data should be prioritized. Suppliers often provide COA (Certificate of Analysis) documentation, which is essential for reproducibility in preclinical studies. As interest grows in precision medicine, the demand for high-quality chiral intermediates like 938462-29-4 is projected to increase, particularly in markets focused on orphan drugs and personalized therapies.

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