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Comprehensive Guide to (R)-2-Amino-3-(4-fluorophenyl)propan-1-ol (CAS No. 348619-91-0): Properties, Applications, and Market Insights

(R)-2-Amino-3-(4-fluorophenyl)propan-1-ol (CAS No. 348619-91-0) is a chiral amino alcohol derivative that has garnered significant attention in pharmaceutical and chemical research. This compound, characterized by its fluorophenyl group and amino alcohol functionality, serves as a versatile intermediate in the synthesis of bioactive molecules. Its unique structural features make it valuable for developing chiral drugs and asymmetric catalysts, aligning with the growing demand for enantioselective synthesis in modern chemistry.

The molecular structure of (R)-2-Amino-3-(4-fluorophenyl)propan-1-ol includes a fluorine substituent on the phenyl ring, which enhances its lipophilicity and metabolic stability—a critical factor in drug design. Researchers frequently explore this compound for its potential in CNS-targeting therapeutics, given the 4-fluorophenyl moiety's prevalence in neurologically active compounds. Recent studies highlight its role in optimizing dopamine receptor ligands, addressing trending topics like neurodegenerative disease treatment and mental health pharmaceuticals.

From a synthetic perspective, CAS 348619-91-0 is often utilized in chiral resolution processes and as a building block for beta-blocker analogs. The compound's (R)-configuration is particularly valuable for creating stereospecific molecules, reflecting the pharmaceutical industry's shift toward single-enantiomer drugs. Analytical techniques such as HPLC chiral separation and X-ray crystallography are commonly employed to verify its optical purity, a key concern for researchers sourcing this material.

The market for (R)-2-Amino-3-(4-fluorophenyl)-1-propanol (alternative naming variant) has expanded due to rising interest in precision medicine and personalized therapeutics. Suppliers now offer this compound in various purity grades (98%-99.5%) to meet diverse research needs. Current pricing trends reflect its niche application status, with bulk quantities available for scale-up projects in API development. Environmental considerations in its synthesis—such as green chemistry approaches to reduce fluorinated waste—have become a hot topic among sustainable chemistry advocates.

Storage and handling recommendations for 348619-91-0 emphasize protection from moisture and oxidation, typically suggesting inert atmosphere packaging. While not classified as hazardous under standard protocols, proper laboratory safety measures should always be observed when working with this amino alcohol compound. The substance's physicochemical properties (including solubility in polar organic solvents and melting point characteristics) make it compatible with common organic synthesis techniques.

Innovative applications continue to emerge for this fluorinated chiral building block, particularly in PET tracer development (leveraging the fluorine-18 isotope) and bioconjugation chemistry. These cutting-edge uses align with search trends around molecular imaging and targeted drug delivery systems. Patent analysis reveals growing IP activity surrounding derivatives of (R)-2-Amino-3-(4-fluorophenyl)propanol, especially in oncology and CNS drug discovery spaces.

Quality control specifications for CAS 348619-91-0 typically include stringent enantiomeric excess requirements (often >99%), with analytical certificates providing detailed spectroscopic data (1H/13C NMR, IR, MS). The compound's stability under various pH conditions and thermal profiles are frequently requested parameters, reflecting formulation scientists' needs. Regulatory status varies by region, but documentation packages usually include REACH compliance statements and impurity profiles for pharmaceutical-grade material.

Future research directions for this compound may explore its potential in biocatalysis routes or as a scaffold for proteolysis-targeting chimeras (PROTACs)—two rapidly growing areas in chemical biology. The continued importance of fluorine-containing pharmaceuticals (approximately 20% of approved drugs contain fluorine) ensures ongoing interest in building blocks like (R)-2-Amino-3-(4-fluorophenyl)propan-1-ol. Suppliers are increasingly offering custom synthesis and isotope-labeled versions to support advanced research applications.

• 148021-84-5((2S)-2-Amino-3-(2-fluorophenyl)propan-1-ol)
• 938462-29-4((S)-2-Amino-3-(3-fluorophenyl)propan-1-ol)
• 35373-68-3(2-amino-3-(3-fluorophenyl)propan-1-ol)
• 64230-78-0(Benzenepropanol, b-amino-4-fluoro-)
• 200267-65-8((S)-2-amino-3-(4-fluorophenyl)propan-1-ol)
• 774243-59-3((R)-2-Amino-3-(3-fluorophenyl)propan-1-ol)
• 218450-18-1(2-amino-3-(3,4-difluorophenyl)propan-1-ol)
• 174302-88-6(2-Amino-3-(2-fluorophenyl)propan-1-ol)
• 35373-69-4(2-amino-3-(4-fluorophenyl)propan-1-ol)
• 64230-77-9(Benzenepropanol, b-amino-3-fluoro-, hydrochloride(1:1))