• 1. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 5. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleoside diphosphates
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Purine ribonucleoside diphosphates

ATPγS Tetralithium Salt (CAS No. 93839-89-5): A Versatile Tool in Biochemical Research

ATPγS tetralithium salt (CAS No. 93839-89-5) is a valuable compound in the field of biochemistry and pharmacology, particularly for its role as a non-hydrolyzable analog of adenosine triphosphate (ATP). This compound has gained significant attention due to its ability to mimic the structural and functional properties of ATP while remaining resistant to enzymatic degradation. This characteristic makes it an indispensable tool in various biochemical assays and studies, including enzyme kinetics, signal transduction pathways, and drug discovery.

The tetralithium salt form of ATPγS is particularly advantageous for its high solubility in aqueous solutions, which facilitates its use in a wide range of experimental conditions. The lithium ions stabilize the compound, enhancing its stability and reducing the risk of precipitation or degradation. This stability is crucial for maintaining the integrity of experimental results and ensuring reproducibility.

Recent research has highlighted the utility of ATPγS tetralithium salt in studying ATP-dependent processes. For instance, a study published in the Journal of Biological Chemistry demonstrated that ATPγS can effectively inhibit ATPase activity in various enzymes, providing insights into the mechanisms of energy transfer and utilization within cells. This inhibition can be used to probe the function of specific enzymes and pathways, offering a powerful tool for both basic research and therapeutic development.

In the context of drug discovery, ATPγS tetralithium salt has been employed to identify and characterize novel inhibitors of ATP-dependent enzymes. By using ATPγS as a competitive inhibitor, researchers can screen libraries of compounds to identify those that effectively compete with ATP for binding sites on target enzymes. This approach has led to the discovery of several promising drug candidates for treating diseases such as cancer and neurodegenerative disorders.

Another area where ATPγS tetralithium salt has shown promise is in the study of G protein-coupled receptors (GPCRs). GPCRs are a large family of membrane receptors that play critical roles in cellular signaling pathways. ATPγS can be used to investigate the coupling efficiency between GPCRs and their downstream effectors, such as G proteins and adenylate cyclase. By understanding these interactions, researchers can develop more effective drugs that modulate GPCR signaling with greater precision.

The use of ATPγS tetralithium salt in high-throughput screening (HTS) platforms has also been explored. HTS is a critical component of modern drug discovery, allowing researchers to rapidly test large numbers of compounds for their biological activity. ATPγS can serve as a positive control in these assays, ensuring that the screening process is robust and reliable. Additionally, it can be used to validate hits identified through HTS by confirming their ability to compete with ATP for binding sites on target enzymes.

Beyond its applications in research, ATPγS tetralithium salt has potential therapeutic uses. For example, it has been investigated as a potential treatment for certain types of cancer by inhibiting ATP-dependent processes that are essential for tumor growth and survival. Preliminary studies have shown promising results, suggesting that ATPγS could be developed into a novel class of anticancer agents.

In conclusion, ATPγS tetralithium salt (CAS No. 93839-89-5) is a versatile compound with a wide range of applications in biochemical research and drug discovery. Its unique properties make it an invaluable tool for investigating ATP-dependent processes and developing new therapeutic strategies. As research continues to advance, it is likely that new applications for this compound will emerge, further solidifying its importance in the scientific community.

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