Production Method 1

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  48 h, reflux

Reference

A novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts

Bringmann, Gerhard; Thomale, Katja; Bischof, Sebastian; Schneider, Christoph; Schultheis, Martina; et al, Antimicrobial Agents and Chemotherapy, 2013, 57(7), 3003-3011

Production Method 2

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ;  3 h, reflux
1.2 6 h, rt

Reference

Synthesis, spectroscopy and computational studies of some biologically important hydroxyhaloquinolines and their novel derivatives

Malecki, Grzegorz; Nycz, Jacek E.; Ryrych, Ewa; Ponikiewski, Lukasz; Nowak, Maria; et al, Journal of Molecular Structure, 2010, 969(1-3), 130-138

Production Method 3

762-42-5

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: 1-Methylimidazole ;  1 min, rt
1.2 20 s, rt; 7 min, 100 °C

Reference

N-methylimidazole-mediated synthesis of aryl alkyl ethers under microwave irradiation and solvent free conditions

Djahaniani, Hoorieh; Aghadadashi-Abhari, Laila; Mohtat, Bita, Journal of the Serbian Chemical Society, 2015, 80(4), 459-464

Production Method 4

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  30 min, rt
1.2 rt; overnight, rt

Reference

Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors

Li, Kun; Li, Ying; Zhou, Di; Fan, Yinbo; Guo, Hongye; et al, Bioorganic & Medicinal Chemistry, 2016, 24(8), 1889-1897

Production Method 5

682351-22-0

938-33-0

Reaction Conditions

1.1 Solvents: Ethanol ;  reflux

Reference

Heteroannulation of 3-bis(methylthio)acrolein with aromatic amines - a convenient highly regioselective synthesis of 2-(methylthio)quinolines and their benzo/hetero fused analogs - a modified skraup quinoline synthesis

Panda, Kausik; Siddiqui, Iffat; Mahata, Pranab K.; Ila, Hiriyakkanavar; Junjappa, Hiriyakkanavar, Synlett, 2004, (3), 449-452

Production Method 6

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Tetrahydrofuran ;  15 min, rt
1.2 rt; overnight, rt

Reference

Experimental and Computational Exploration of para-Selective Silylation with a Hydrogen-Bonded Template

Maji, Arun ; Guin, Srimanta; Feng, Sheng; Dahiya, Amit; Singh, Vikas Kumar; et al, Angewandte Chemie, 2017, 56(47), 14903-14907

Production Method 7

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Tetrahydrofuran ;  rt; overnight, rt

Reference

Preparation of 1,2,3,4-tetrahydroquinoline derivative useful in the treatment of diabetes

, World Intellectual Property Organization, , ,

Production Method 8

53899-17-5

938-33-0

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Oxygen Solvents: 2-Methyl-2-butanol ;  10 - 24 h, 120 °C

Reference

KOtBu/O2 Mediated Dehydrogenation of N-Heterocycles, Alcohols

Fu, Xuegang; Wang, Yue; Liu, Liu; Li, Caifeng; Huang, Lin; et al, ChemistrySelect, 2022, 7(30),

Production Method 9

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  rt; overnight, rt

Reference

Development of highly selective dual mode chromogenic and fluorogenic chemosensor for Bi3+ ions

Saravana Kumar, S.; Selva Kumar, R.; Ashok Kumar, S. K., Journal of Molecular Structure, 2020, 1212,

Production Method 10

504-63-2

938-33-0

Reaction Conditions

1.1 Catalysts: Bismuth cobalt carbonate oxide (Bi2Co(CO3)O2) ;  48 h, 150 °C

Reference

Sustainable synthesis of azobenzenes, quinolines and quinoxalines via oxidative dehydrogenative couplings catalysed by reusable transition metal oxide-Bi(iii) cooperative catalysts

Kocsis, Marianna; Baan, Kornelia; Otvos, Sandor B.; Kukovecz, Akos; Konya, Zoltan; et al, Catalysis Science & Technology, 2023, 13(10), 3069-3083

Production Method 11

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  rt; 24 h, reflux

Reference

Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines

Hassan, Mirja Mahamudul Md; Hoque, Emdadul Md; Dey, Sayan; Guria, Saikat; Roy, Brindaban; et al, Synthesis, 2021, 53(18), 3333-3342

Production Method 12

148-24-3

938-33-0

Reaction Conditions

1.1 Solvents: Acetonitrile ;  30 min, rt

Reference

Polymer supported synthesis of bioactive heterocyclic compounds

More, Uttam B.; Narkhede, Hemant P.; Raut, Changdeo N.; Mahulikar, Pramod P., Indian Journal of Heterocyclic Chemistry, 2009, 19(1), 43-46

Production Method 13

148-24-3

938-33-0

Reaction Conditions

1.1 Catalysts: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Dimethylformamide ;  10 min, 220 °C

Reference

A Continuous Base-Catalyzed Methylation of Phenols with Dimethyl Carbonate

Tilstam, Ulf, Organic Process Research & Development, 2012, 16(5), 1150-1153

Production Method 14

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  cooled; 8 h, rt
1.2 Reagents: Ethanol ;  rt

Reference

Tetradentate cyclometal platinum(II) and palladium(II) complex luminescent material containing quinoline structural unit and application thereof

, World Intellectual Property Organization, , ,

Production Method 15

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  rt; 8 h, cooled
1.2 Reagents: Ethanol

Reference

Metal platinum(II) and palladium(II) complex containing quinoline structural unit and bridging structure, organic light-emitting device and display or lighting device containing the same

, China, , ,

Production Method 16

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Catalysts: Sodium iodide Solvents: Dimethylformamide ;  rt; overnight, rt
1.2 Reagents: Ethanol ;  rt

Reference

5/6/6-Ring-fused tetradentate cyclometallated platinum(II) complex phosphorescent material based on quinoline unit structure and application thereof in electroluminescence devices

, China, , ,

Production Method 17

611-33-6

938-33-0

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: [3,6-Dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]bis(1,1-dimethyl… ,  Palladium(1+), [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][[3,6-dimethoxy-2′,4′,6′-tr… Solvents: 1,4-Dioxane ;  20 h, 50 °C

Reference

Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst

Cheung, Chi Wai; Buchwald, Stephen L., Organic Letters, 2013, 15(15), 3998-4001

Production Method 18

148-24-3

938-33-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Dimethylformamide ,  Tetrahydrofuran ;  12 h, rt
1.2 Reagents: Water

Reference

Preparation of tetracyclic xanthene amino acid derivatives for treatment of viral diseases

, World Intellectual Property Organization, , ,

8-Methoxyquinoline Raw materials

• 1,4-dimethyl but-2-ynedioate
• 1,3-Propanediol
• QUINOLINE, 8-METHOXY-2-(METHYLTHIO)-
• 8-Hydroxyquinoline
• 8-Chloroquinoline
• 8-Methoxy-1,2,3,4-tetrahydroquinoline

8-Methoxyquinoline Preparation Products

• 8-Methoxyquinoline (938-33-0)

• 1. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 2. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 3. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 4. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 5. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829

• 58868-41-0(Quinoline,5,8-dimethoxy-)
• 3189-22-8(7-methoxy-1H-indole)
• 39112-64-6( )
• 6931-17-5(3-Methoxyquinoline)
• 951-06-4(4,7-Phenanthroline,5-methoxy-)
• 477601-28-8(6-methoxyquinolin-8-ol)
• 214349-09-4(8-methoxyquinolin-3-ol)
• 116451-32-2(5-methoxy-1H-Pyrrolo[2,3-f]quinoline)
• 111454-91-2(6,8-Dimethoxyquinoline)
• 1015460-60-2(6-methoxy-5H-Pyrido[4,3-b]indole)