Production Method 1

1402586-10-0

937843-60-2

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: p-Toluenesulfonic acid Solvents: Tetrahydrofuran ;  6 h, reflux

Reference

Substituted phenylureas and phenylamides as vanilloid receptor ligands and their preparation

, United States, , ,

Production Method 2

1402586-10-0

937843-60-2

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: p-Toluenesulfonic acid monohydrate Solvents: Tetrahydrofuran ;  6 h, reflux

Reference

Preparation of methylsulfonamidomethylphenylpryidinylmethylpropanamide derivatives and analogs for use as vanilloid receptor ligands

, United States, , ,

Production Method 3

1402586-10-0

937843-60-2

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: p-Toluenesulfonic acid Solvents: Tetrahydrofuran ;  6 h, reflux

Reference

Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an N-containing group as vanilloid receptor ligands and their preparation

, World Intellectual Property Organization, , ,

Production Method 4

1402586-10-0

937843-60-2

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: p-Toluenesulfonic acid monohydrate Solvents: Tetrahydrofuran ;  6 h, reflux

Reference

Preparation of amine substituted methanesulfonamide derivatives as vanilloid receptor ligands

, United States, , ,

Production Method 5

1402586-10-0

937843-60-2

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Tetrahydrofuran ;  6 h, reflux; reflux → rt
1.2 Reagents: Potassium bicarbonate ;  pH 12 - 13, rt

Reference

Preparation of methylsulfonamidomethylphenylpyridinylmethylpropanamide derivatives and analogs for use as vanilloid receptor ligands

, United States, , ,

Production Method 6

1427-07-2

937843-60-2

Reaction Conditions

1.1 Reagents: Benzoyl peroxide ,  N-Bromosuccinimide Solvents: Carbon tetrachloride ;  15 h, reflux
1.2 Reagents: Potassium phthalimide Solvents: Dimethylformamide ;  15 h, rt
1.3 Reagents: Hydrazine hydrate (1:1) Catalysts: p-Toluenesulfonic acid Solvents: Tetrahydrofuran ;  6 h, reflux

Reference

Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template

Ann, Jihyae; Sun, Wei; Zhou, Xing; Jung, Aeran; Baek, Jisoo; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(15), 3603-3607

(2-fluoro-4-nitrophenyl)methanamine Raw materials

• 2-fluoro-1-methyl-4-nitro-benzene
• 2-(2-Fluoro-4-nitrobenzyl)isoindoline-1,3-dione

(2-fluoro-4-nitrophenyl)methanamine Preparation Products

• (2-fluoro-4-nitrophenyl)methanamine (937843-60-2)

• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
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• 4. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 5. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)