Production Method 1

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Water Catalysts: Indium triflate Solvents: Sulfur dioxide ;  -78 °C; 16 - 18 h, 8 bar, 60 °C

Reference

In(III) and Hf(IV) Triflate-Catalyzed Hydration and Catalyst-free Hydrohalogenation of Aryl Acetylenes in Liquid Sulfur Dioxide

Suta, Krista; Turks, Maris, ACS Omega, 2018, 3(12), 18065-18077

Production Method 2

4433-63-0

99-90-1

937-30-4

Reaction Conditions

1.1 Catalysts: Di-μ-chlorobis(η3-2-propenyl)dipalladium ,  rel-1,1′,1′′,1′′′-[(1R,2R,3S,4S)-1,2,3,4-Cyclopentanetetrayltetrakis(methylene)]… Solvents: Tetrahydrofuran ;  10 min, rt
1.2 Reagents: Potassium carbonate Solvents: Xylene ;  20 h, 130 °C

Reference

Tetraphosphine/palladium-catalyzed Suzuki cross-coupling reactions of aryl halides with alkylboronic acids

Kondolff, Isabelle; Doucet, Henri; Santelli, Maurice, Tetrahedron, 2004, 60(17), 3813-3818

Production Method 3

40307-11-7

937-30-4

Reaction Conditions

1.1 Catalysts: Chloro[(isocyano-κC)cyclohexane]gold ,  Potassium tetrakis(pentafluorophenyl)borate Solvents: Methanol ,  Water ;  24 h, rt

Reference

Hydration of alkynes at room temperature catalyzed by gold(I) isocyanide compounds

Xu, Yun; Hu, Xingbang; Shao, Jing; Yang, Guoqiang; Wu, Youting; et al, Green Chemistry, 2015, 17(1), 532-537

Production Method 4

33967-18-9

937-30-4

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: 9,10-Dicyanoanthracene Solvents: Acetonitrile ;  60 min, rt

Reference

9,10-Dicyanoanthracene photosensitized oxidation of aryl alkanols: evidence for an electron transfer mechanism

Lykakis, Ioannis N.; Lestakis, Stellios; Orfanopoulos, Michael, Tetrahedron Letters, 2003, 44(33), 6247-6251

Production Method 5

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Water Catalysts: Silver hexafluoroantimonate ,  1514905-15-7 Solvents: Methanol ;  24 h, 120 °C

Reference

Au-NHC@Porous Organic Polymers: Synthetic Control and Its Catalytic Application in Alkyne Hydration Reactions

Wang, Wenlong; Zheng, Anmin; Zhao, Peiqing; Xia, Chungu; Li, Fuwei, ACS Catalysis, 2014, 4(1), 321-327

Production Method 6

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Silver triflate Catalysts: 2378834-33-2 Solvents: Acetic acid ,  Water ;  10 h, 100 °C

Reference

The synthesis of methyl triazole-4-carboxylate gold(I) complex and application on allene synthesis and alkyne hydration

Hu, Wenkang; Shan, Liang; Ma, Fudong; Zhang, Yilin; Yang, Yongchun; et al, Inorganic Chemistry Communications, 2019, 109,

Production Method 7

13045-22-2

937-30-4

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Ethylene glycol diethyl ether ;  rt; 12 h, 90 °C

Reference

1,2-Diethoxyethane catalyzed oxidative cleavage of gem-disubstituted aromatic alkenes to ketones under minimal solvent conditions

Liu, Kai-Jian; Deng, Ji-Hui; Zeng, Tang-Yu; Chen, Xin-Jie; Huang, Ying; et al, Chinese Chemical Letters, 2020, 31(7), 1868-1872

Production Method 8

10537-63-0

937-30-4

Reaction Conditions

1.1 Catalysts: Sodium tert-butoxide ,  Iridium, [9-[[bis(1,1-dimethylethyl)phosphino-κP]oxy]benzo[h]quinolin-10-yl-κC,κ… Solvents: Ethanol ;  30 min, 60 °C
1.2 Reagents: Oxygen

Reference

Transfer Hydrogenation of Alkenes Using Ethanol Catalyzed by a NCP Pincer Iridium Complex: Scope and Mechanism

Wang, Yulei; Huang, Zhidao; Leng, Xuebing; Zhu, Huping; Liu, Guixia; et al, Journal of the American Chemical Society, 2018, 140(12), 4417-4429

Production Method 9

1009-61-6

937-30-4

Reaction Conditions

1.1 Reagents: Hydrogen ,  1-Butyl-3-methylimidazolium tetrafluoroborate Catalysts: Palladium ;  20 h, 30 bar, 120 °C

Reference

Hydrogen-Bonding-Mediated Selective Hydrogenation of Aromatic Ketones over Pd/C in Ionic Liquids at Room Temperature

Li, Ruipeng; Wang, Yuepeng; Zhao, Yanfei; Zhang, Fengtao; Zeng, Wei; et al, ACS Sustainable Chemistry & Engineering, 2021, 9(42), 14216-14223

Production Method 10

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Water Catalysts: Sulfuric acid Solvents: Acetonitrile ;  20 min, rt

Reference

Accelerated Metal-Free Hydration of Alkynes within Milliseconds in Microdroplets

Zheng, Boyu; Jin, Xiaoxiao; Liu, Jinhua; Cheng, Heyong, ACS Sustainable Chemistry & Engineering, 2021, 9(12), 4383-4390

Production Method 11

15519-23-0

937-30-4

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane ,  Sodium iodide Solvents: Acetonitrile

Reference

Extended scope of in situ iodotrimethylsilane mediated selective reduction of benzylic alcohols

Cain, Gary A.; Holler, Edward R., Chemical Communications (Cambridge, 2001, (13), 1168-1169

Production Method 12

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Water Catalysts: 2750707-54-9 (salt with hexafluoroantimonate) ;  20 h, 60 °C

Reference

Synthesis and Catalytic Properties of Metal-N-Heterocyclic-Carbene-Decorated Covalent Organic Framework

Li, Yue; Dong, Ying; Kan, Jing-Lan; Wu, Xiaowei; Dong, Yu-Bin, Organic Letters, 2020, 22(18), 7363-7368

Production Method 13

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Water Catalysts: Molybdate(3-), cobaltatehexa-μ3-hydroxyhexa-μ-oxododecaoxohexa-, ammonium (1:3) Solvents: Formic acid ;  1 h, 60 °C

Reference

Hydration of Alkynes to Ketones with an Efficient and Practical Polyoxomolybdate-based Cobalt Catalyst

Xie, Ya; Wang, Jingjing; Wang, Yunyun; Han, Sheng; Yu, Han, ChemCatChem, 2021, 13(23), 4985-4989

Production Method 14

40307-11-7

937-30-4

Reaction Conditions

1.1 Reagents: Acetic acid ,  p-Toluenesulfonic acid Solvents: Dichloromethane ;  3 h, 50 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

A Combination System of p-Toluenesulfonic Acid and Acetic Acid for the Hydration of Alkynes

Liu, Haixuan; Wei, Yunyang; Cai, Chun, Synlett, 2016, 27(16), 2378-2383

Production Method 15

10537-63-0

937-30-4

Reaction Conditions

1.1 Reagents: 1,4-Dioxane Catalysts: Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium ,  1,2-Bis(dicyclohexylphosphino)ethane ;  5 min, rt
1.2 10 h, 130 °C

Reference

Iridium-Catalyzed Alkene-Selective Transfer Hydrogenation with 1,4-Dioxane as Hydrogen Donor

Zhang, Deliang; Iwai, Tomohiro; Sawamura, Masaya, Organic Letters, 2019, 21(15), 5867-5872

Production Method 16

13329-40-3

937-30-4

Reaction Conditions

1.1 Reagents: Zinc ,  Sodium iodide Catalysts: Dichloro[1,1′-(1,3-propanediyl)bis[1,1-diphenylphosphine-κP]]nickel Solvents: Tetrahydrofuran ;  24 h, rt

Reference

Nickel-Catalyzed Methylation of Aryl Halides with Deuterated Methyl Iodide

Hu, Lu; Liu, Xin; Liao, Xuebin, Angewandte Chemie, 2016, 55(33), 9743-9747

Production Method 17

937-30-4

Reaction Conditions

1.1 Reagents: Potassium bromide ,  Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Acetonitrile ,  Water ;  4 h, 45 °C

Reference

Oxidation of benzylic methylenes to ketones with Oxone-KBr in aqueous acetonitrile under transition metal free conditions

Yin, Lixia; Wu, Jingjing; Xiao, Juan; Cao, Song, Tetrahedron Letters, 2012, 53(33), 4418-4421

Production Method 18

40307-11-7

937-30-4

Reaction Conditions

1.1 Catalysts: [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chlorog… Solvents: Methanol ,  Water ;  6 h, 110 °C

Reference

Process for preparation of ketone compounds through alkyne hydrolysis

, China, , ,

Production Method 19

40307-11-7

937-30-4

Reaction Conditions

1.1 Catalysts: [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chlorog… Solvents: Methanol ,  Water ;  6 h, 110 °C; 110 °C → rt

Reference

Regioselective Hydration of Terminal Alkynes Catalyzed by a Neutral Gold(I) Complex [(IPr)AuCl] and One-Pot Synthesis of Optically Active Secondary Alcohols from Terminal Alkynes by the Combination of [(IPr)AuCl] and Cp*RhCl[(R,R)-TsDPEN]

Li, Feng; Wang, Nana; Lu, Lei; Zhu, Guangjun, Journal of Organic Chemistry, 2015, 80(7), 3538-3546

Production Method 20

40307-11-7

937-30-4

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid ,  Indium triflate Solvents: 1,2-Dichloroethane ,  Water ;  3.5 h, reflux

Reference

The indium-catalysed hydration of alkynes using substoichiometric amounts of PTSA as additive

Gao, Qi; Li, Shenyan; Pan, Yingming; Xu, Yanli; Wang, Hengshan, Tetrahedron, 2013, 69(19), 3775-3781

4'-Ethylacetophenone Raw materials

• Ethanone, 1-[4-(1-hydroxyethyl)phenyl]-
• BENZENE, 1-ETHYL-4-(1-METHYLETHENYL)-
• Ethylboronic acid
• 1-(4-Ethenylphenyl)ethan-1-one
• 1-Ethyl-4-ethynylbenzene
• 4'-Iodoacetophenone
• 4’-Bromoacetophenone
• 1,1'-(1,4-phenylene)bis-Ethanone
• 1-(4-ethylphenyl)ethan-1-ol

4'-Ethylacetophenone Preparation Products

• 4'-Ethylacetophenone (937-30-4)

• 1. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 2. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 3. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 4. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl-phenylketones
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 585-74-0(1-(m-tolyl)ethanone)
• 22699-70-3(1-(3-ethylphenyl)ethan-1-one)
• 10383-88-7(Ethanone-1-13C,1-phenyl-)
• 190314-15-9(Ethanone-1,2-13C2,1-phenyl-)
• 6781-42-6(1,3-Diacetylbenzene)
• 1009-61-6(1,1'-(1,4-phenylene)bis-Ethanone)
• 5379-16-8(1-(3,5-Dimethylphenyl)ethanone)
• 122-00-9(4'-Methylacetophenone)
• 98-86-2(Acetophenone)
• 19547-00-3(Acetophenone-d8)