Production Method 1

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  16 h, 80 °C

Reference

Preparation of amino-pyrimidine compounds as inhibitors of TBK1 kinase and IKK kinase epsilon

, World Intellectual Property Organization, , ,

Production Method 2

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

Reference

Antibody-ALK5 inhibitor conjugates and their uses

, World Intellectual Property Organization, , ,

Production Method 3

132131-24-9

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethylformamide ;  4 h, rt → 80 °C

Reference

Preparation of triazolylanilinoquinazolines as antivirals.

, World Intellectual Property Organization, , ,

Production Method 4

2524-67-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  4 h, rt → 80 °C

Reference

Quinazoline derivatives, useful in treating or preventing a flaviviridae infection, processes for preparing them, and pharmaceutical compositions containing them

, World Intellectual Property Organization, , ,

Production Method 5

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  20 h, 80 °C

Reference

Amide compound having BET proteolysis-inducing action, and medicinal application thereof

, World Intellectual Property Organization, , ,

Production Method 6

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  30 min, 85 °C

Reference

Pyrrolopyridines and related compounds as Tank-binding kinase inhibitors and their preparation

, United States, , ,

Production Method 7

5922-60-1

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Sodium acetate Catalysts: Tricyclohexylphosphine ,  Tris(dibenzylideneacetone)dipalladium Solvents: 1,4-Dioxane ;  30 h, 90 °C
1.2 Reagents: Water

Reference

Pyrazolopyridine derivatives for use in the treatment of bladder cancer

, World Intellectual Property Organization, , ,

Production Method 8

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  16 h, 80 °C

Reference

Nitrogen-containing heterocyclic compound, its preparation method, intermediate, composition and application

, China, , ,

Production Method 9

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ;  16 h, 80 °C

Reference

Preparation of nitrogenous heterocyclic compounds as ErbB2 inhibitors

, World Intellectual Property Organization, , ,

Production Method 10

1885-29-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Catalysts: Bis[(1,2,5,6-η)-1,5-cyclooctadiene]di-μ-methoxydiiridium ,  2861929-14-6 Solvents: Tetrahydrofuran ;  2 min, rt
1.2 12 h, rt

Reference

Ligand- and Substrate-Controlled para C-H Borylation of Anilines at Room Temperature

Haldar, Chabush ; Bisht, Ranjana; Chaturvedi, Jagriti; Guria, Saikat; Hassan, Mirja Mahamudul Md; et al, Organic Letters, 2022, 24(44), 8147-8152

Production Method 11

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  16 h, 80 °C; cooled

Reference

Preparation of substituted pyrimidinylbenzonitriles as IKK-related kinase ε and TANK-binding kinase 1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 12

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  1 h, 130 °C

Reference

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation

Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; et al, European Journal of Medicinal Chemistry, 2017, 141, 446-459

Production Method 13

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethyl sulfoxide ;  overnight, 80 °C

Reference

Preparation of indazole compounds as glucokinase activators for treating diabetes and obesity

, World Intellectual Property Organization, , ,

Production Method 14

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ,  Water ;  rt → 70 °C; overnight, 70 °C

Reference

Preparation of substituted pyridinecarboxamides and benzamides useful in cancer treatments targeting cancer stem cells

, World Intellectual Property Organization, , ,

Production Method 15

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ;  10 min, rt → 110 °C

Reference

Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors

More, Kunal N.; Hong, Victor S.; Lee, Ahyeon; Park, Jongsung; Kim, Shin; et al, Bioorganic & Medicinal Chemistry Letters, 2018, 28(14), 2513-2517

Production Method 16

5922-60-1

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Sodium acetate Catalysts: Tricyclohexylphosphine ,  Tris(dibenzylideneacetone)dipalladium Solvents: 1,4-Dioxane ;  30 h, 90 °C
1.2 Reagents: Water

Reference

Process for the preparation of pyrazolopyridine derivatives and therapeutic use thereof

, United States, , ,

Production Method 17

39263-32-6

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ;  2 d, 80 °C

Reference

Aminotriazine derivatives as tank-binding kinase inhibitor and their preparation

, World Intellectual Property Organization, , ,

Production Method 18

5922-60-1

73183-34-3

934426-22-9

Reaction Conditions

1.1 Reagents: Sodium acetate Catalysts: Tricyclohexylphosphine ,  Tris(dibenzylideneacetone)dipalladium Solvents: 1,4-Dioxane ;  30 h, 90 °C
1.2 Solvents: Water

Reference

Preparation of pyrazolopyridines as fibroblast growth factor (FGF) inhibitors, particularly FGF antagonists, and as angiogenesis inhibitors for treatment of inflammation, cancer and cardiovascular diseases

, France, , ,

2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile Raw materials

• Anthranilonitrile
• 2-Amino-5-chlorobenzonitrile
• 2-Amino-5-iodobenzonitrile
• 2-Amino-5-bromobenzonitrile
• 4-(morpholin-4-yl)aniline
• Bis(pinacolato)diborane

2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile Preparation Products

• 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (934426-22-9)

• 1. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 2. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 3. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
  Xue-Ying Wang,Ying Pei,Min Xie,Zi-He Jin,Ya-Shi Xiao,Yang Wang,Li-Na Zhang,Yan Li,Wei-Hua Huang Lab Chip, 2015,15, 1178-1187
• 4. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 5. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

• 171364-82-2(4-(Cyanophenyl)boronic Acid Pinacol Ester)
• 1220219-59-9(3-Cyano-5-methylphenylboronic acid pinacol ester)
• 850567-52-1(3-Amino-4-methylphenylboronic acid, pinacol ester, hydrochloride)
• 1220219-11-3(3-Cyano-4-methylphenylboronic acid, pinacol ester)
• 590418-05-6(2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)aniline)
• 214360-46-0(3-Cyanophenylboronic acid, pinacol ester)
• 863868-34-2(5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-dicarbonitrile)
• 775351-54-7(2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)-benzonitrile)
• 882678-96-8(2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline)
• 1004761-68-5(4-Amino-3,5-dimethylphenylboronic Acid Pinacol Ester)