• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

Recent Advances in the Application of 3-Cyano-4-methylphenylboronic acid, pinacol ester (CAS: 1220219-11-3) in Chemical Biology and Pharmaceutical Research

3-Cyano-4-methylphenylboronic acid, pinacol ester (CAS: 1220219-11-3) is a boronic acid derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound, characterized by its cyano and methyl substituents on the phenyl ring and the pinacol ester protecting group, serves as a crucial building block in Suzuki-Miyaura cross-coupling reactions, which are widely employed in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals. The unique electronic and steric properties of this boronic ester make it particularly valuable for the construction of biaryl systems, which are prevalent in many bioactive compounds.

Recent studies have highlighted the role of 3-Cyano-4-methylphenylboronic acid, pinacol ester in the development of novel therapeutic agents. For instance, researchers have utilized this compound as a key intermediate in the synthesis of tyrosine kinase inhibitors, which are pivotal in targeted cancer therapies. The boronic ester moiety facilitates the formation of carbon-carbon bonds under mild conditions, enabling the efficient assembly of structurally diverse inhibitors with enhanced selectivity and potency. Additionally, its stability under physiological conditions has made it a promising candidate for prodrug strategies, where the boronic acid is released upon enzymatic cleavage in vivo.

In the context of chemical biology, 3-Cyano-4-methylphenylboronic acid, pinacol ester has been employed as a molecular probe to investigate protein-ligand interactions. Its ability to form reversible covalent bonds with diols and other nucleophiles has been exploited in the design of activity-based probes for glycosidases and other enzymes. Recent work has demonstrated its utility in profiling enzyme activities in complex biological samples, providing insights into disease mechanisms and potential therapeutic targets. Furthermore, the compound's fluorescence properties have been leveraged for the development of biosensors, enabling real-time monitoring of enzymatic reactions and cellular processes.

Despite its promising applications, challenges remain in the optimization of 3-Cyano-4-methylphenylboronic acid, pinacol ester for specific biomedical uses. Issues such as solubility, bioavailability, and off-target effects need to be addressed through structural modifications and formulation strategies. Recent advances in computational chemistry and high-throughput screening have facilitated the rational design of derivatives with improved pharmacokinetic profiles. Collaborative efforts between chemists, biologists, and pharmacologists are essential to fully harness the potential of this compound in drug discovery and development.

Looking ahead, the integration of 3-Cyano-4-methylphenylboronic acid, pinacol ester into emerging technologies such as PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs) holds great promise. Its compatibility with bioorthogonal chemistry and click reactions further expands its utility in bioconjugation and targeted delivery systems. As research continues to uncover new applications and refine existing methodologies, this boronic ester is poised to play an increasingly important role in the advancement of chemical biology and pharmaceutical sciences.

• 171364-82-2(4-(Cyanophenyl)boronic Acid Pinacol Ester)
• 863868-32-0(4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile)
• 1220219-59-9(3-Cyano-5-methylphenylboronic acid pinacol ester)
• 401797-00-0(2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 863868-22-8(4-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile)
• 1231892-37-7(3-Cyano-2-methylphenylboronic Acid Pinacol Ester)
• 214360-46-0(3-Cyanophenylboronic acid, pinacol ester)
• 863868-34-2(5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-dicarbonitrile)
• 775351-54-7(2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)-benzonitrile)
• 406482-72-2(4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-4-carbonitrile)