Production Method 1

933988-19-3

933988-20-6

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3

Reference

Pyrimidine hydrazide compounds as PGDS inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 2

933988-19-3

933988-20-6

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, rt

Reference

Preparation of pyrimidine amide derivatives as prostaglandin D synthase inhibitors

, World Intellectual Property Organization, , ,

2-pyridin-3-ylpyrimidine-5-carboxylic Acid Raw materials

• Methyl 2-(pyridin-3-yl)pyrimidine-5-carboxylate

2-pyridin-3-ylpyrimidine-5-carboxylic Acid Preparation Products

• 2-pyridin-3-ylpyrimidine-5-carboxylic Acid (933988-20-6)

• 1. Enantiomeric helical TiO2 nanofibers modulate different peptide assemblies and subsequent cellular behaviors?
  Xu Jie,Deng Xu,Weili Wei RSC Adv., 2019,9, 29149-29153
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 4. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 5. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151

Recent Advances in the Study of 2-pyridin-3-ylpyrimidine-5-carboxylic Acid (CAS: 933988-20-6) in Chemical Biology and Pharmaceutical Research

2-pyridin-3-ylpyrimidine-5-carboxylic Acid (CAS: 933988-20-6) has emerged as a compound of significant interest in chemical biology and pharmaceutical research due to its versatile applications in drug discovery and development. Recent studies have highlighted its potential as a key intermediate in the synthesis of novel kinase inhibitors, particularly those targeting cancer-related pathways. The compound's unique pyridine-pyrimidine scaffold offers a promising structural motif for modulating protein-protein interactions and enzymatic activities, making it a valuable tool in medicinal chemistry.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the efficacy of 2-pyridin-3-ylpyrimidine-5-carboxylic Acid derivatives as selective inhibitors of fibroblast growth factor receptors (FGFRs), which are implicated in various cancers. The research team utilized structure-activity relationship (SAR) analysis to optimize the compound's binding affinity, achieving nanomolar potency against FGFR1-3 isoforms. These findings suggest that 933988-20-6-based compounds could serve as promising candidates for targeted cancer therapies with reduced off-target effects compared to existing treatments.

In the field of neurodegenerative diseases, recent investigations have explored the neuroprotective properties of 2-pyridin-3-ylpyrimidine-5-carboxylic Acid derivatives. A preclinical study published in ACS Chemical Neuroscience (2024) reported that modified versions of this compound exhibited significant antioxidant and anti-inflammatory effects in cellular models of Parkinson's disease. The researchers attributed these effects to the compound's ability to chelate redox-active metals and modulate microglial activation pathways, opening new avenues for developing multifunctional neurotherapeutic agents.

The synthetic accessibility of 933988-20-6 has also been improved through recent methodological advances. A 2024 publication in Organic Process Research & Development described a novel continuous-flow synthesis approach that increased the yield of 2-pyridin-3-ylpyrimidine-5-carboxylic Acid by 35% while reducing production costs and environmental impact. This technological innovation addresses previous challenges in large-scale production, potentially accelerating the translation of research findings into clinical applications.

Emerging research has also identified unexpected applications of this compound in antibiotic development. A recent study in Nature Chemical Biology (2023) revealed that certain 2-pyridin-3-ylpyrimidine-5-carboxylic Acid derivatives can disrupt bacterial quorum sensing systems, offering a potential strategy to combat antibiotic-resistant pathogens without exerting direct bactericidal pressure that could drive resistance development.

As research on 933988-20-6 continues to expand, several pharmaceutical companies have initiated preclinical development programs based on this scaffold. Current challenges include optimizing the pharmacokinetic properties of these compounds and addressing potential metabolic stability issues. However, the growing body of evidence suggests that 2-pyridin-3-ylpyrimidine-5-carboxylic Acid and its derivatives hold substantial promise for addressing unmet medical needs across multiple therapeutic areas.

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