Production Method 1

29241-66-5

931105-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  20 h, rt

Reference

Preparation of 3-(pyrimidin-5-yl)-2-fluorobenzyl carbamimidoylcarbamate and 3-(pyridin-3-yl)-2-fluorobenzyl carbamimidoylcarbamate derivatives as VA P-1 (vascular adhesion protein-1) inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

78686-79-0

931105-37-2

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethyl sulfoxide ;  2 d, rt; 4 h, 60 °C; cooled

Reference

Preparation of heterocyclic Met kinase inhibitors for use in treating cancer

, United States, , ,

Production Method 3

78686-79-0

931105-37-2

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethyl sulfoxide ;  45 °C; 48 h, 50 °C

Reference

Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]Pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 2

Kaieda, Akira ; Takahashi, Masashi ; Fukuda, Hiromi; Okamoto, Rei; Morimoto, Shinji; et al, ChemMedChem, 2019, 14(24), 2093-2101

Production Method 4

78686-79-0

931105-37-2

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethyl sulfoxide ;  45 °C; 48 h, 50 °C

Reference

Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1

Kaieda, Akira ; Takahashi, Masashi ; Fukuda, Hiromi; Okamoto, Rei; Morimoto, Shinji; et al, ChemMedChem, 2019, 14(10), 1022-1030

Production Method 5

78686-79-0

931105-37-2

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethyl sulfoxide ;  48 h, 45 - 50 °C

Reference

Preparation of fused heterocyclic compounds as p38 MAP kinase inhibitors and inhibitors of TNF-α production

, World Intellectual Property Organization, , ,

Production Method 6

29241-66-5

931105-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, 25 °C

Reference

Chiral amides as SOS1 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer and other diseases

, World Intellectual Property Organization, , ,

methyl 5-bromo-2-fluoropyridine-3-carboxylate Raw materials

• 5-bromo-2-fluoropyridine-3-carboxylic acid
• methyl 5-bromo-2-chloropyridine-3-carboxylate

methyl 5-bromo-2-fluoropyridine-3-carboxylate Preparation Products

• methyl 5-bromo-2-fluoropyridine-3-carboxylate (931105-37-2)

• 1. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 4. An apparatus for determining small amounts of alchohol in sour milk and urine
  Analyst, 1964,89, 272-275
• 5. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

• 29241-66-5(5-bromo-2-fluoropyridine-3-carboxylic acid)
• 117671-02-0(2,6-Difluoro-nicotinic Acid Methyl Ester)
• 29241-63-2(5-Bromo-6-fluoronicotinic acid)
• 113898-56-9(Ethyl 2-fluoropyridine-3-carboxylate)
• 1214362-74-9(Ethyl 5-bromo-2-fluoro-3-pyridinecarboxylate)
• 1240611-45-3(Methyl 4-bromo-2-fluoronicotinate)
• 446-26-4(Methyl 2-fluoronicotinate)
• 939812-72-3(Ethyl 2,6-difluoronicotinate)
• 405939-62-0(methyl 5-bromo-6-fluoropyridine-3-carboxylate)
• 875781-15-0(5-bromo-2-fluoro-pyridine-3-carbaldehyde)