• 1. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 2. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 3. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

Ethyl 2-fluoropyridine-3-carboxylate (CAS No. 113898-56-9): A Key Intermediate in Modern Pharmaceutical Synthesis

Ethyl 2-fluoropyridine-3-carboxylate, identified by its CAS number 113898-56-9, is a versatile and highly valuable intermediate in the realm of pharmaceutical chemistry. This compound, featuring a fluorinated pyridine core and a carboxylate ester group, has garnered significant attention in recent years due to its utility in the synthesis of bioactive molecules. The presence of a fluorine atom at the 2-position of the pyridine ring imparts unique electronic and steric properties, making it an attractive scaffold for drug discovery and development.

The< strong>Ethyl 2-fluoropyridine-3-carboxylate molecule serves as a critical building block in the construction of more complex pharmacophores. Its structural features allow for facile modifications at both the carboxylate and fluorine positions, enabling chemists to tailor molecular properties such as solubility, bioavailability, and metabolic stability. These attributes are particularly important in the design of novel therapeutic agents targeting various diseases, including cancer, infectious disorders, and neurological conditions.

In recent years, there has been a surge in research focusing on fluorinated heterocycles due to their enhanced binding affinity and metabolic resistance compared to their non-fluorinated counterparts. The< strong>fluoropyridine moiety, in particular, has been extensively studied for its role in modulating receptor interactions and improving drug efficacy. Ethyl 2-fluoropyridine-3-carboxylate is no exception, with its applications spanning across multiple therapeutic areas.

One of the most compelling aspects of< strong>Ethyl 2-fluoropyridine-3-carboxylate is its role in the synthesis of kinase inhibitors. Kinases are enzymes that play a pivotal role in cell signaling pathways, and their dysregulation is often associated with various diseases, most notably cancer. By incorporating this intermediate into drug candidates, researchers can develop molecules that selectively inhibit aberrant kinase activity. For instance, studies have demonstrated that derivatives of< strong>Ethyl 2-fluoropyridine-3-carboxylate exhibit potent inhibitory effects against tyrosine kinases, making them promising candidates for further development.

The carboxylate ester group in< strong>Ethyl 2-fluoropyridine-3-carboxylate also provides a versatile handle for further functionalization. This functionality can be hydrolyzed to yield a free carboxylic acid group or converted into other derivatives such as amides or esters. Such transformations are essential for linking this intermediate to other pharmacophores or for modifying its physicochemical properties. This adaptability makes it an indispensable tool in medicinal chemistry libraries.

Another area where< strong>Ethyl 2-fluoropyridine-3-carboxylate has shown promise is in the development of antiviral agents. The fluoro-pyridine scaffold has been found to enhance the antiviral activity of several compounds by improving their ability to interact with viral targets. For example, researchers have utilized this intermediate to synthesize inhibitors of viral proteases and polymerases, which are crucial for viral replication. The< strong>CAS No. 113898-56-9-labeled compound has been instrumental in these efforts, providing a scaffold that can be modified to target specific viral strains.

The synthesis of< strong>Ethyl 2-fluoropyridine-3-carboxylate itself is another area of interest within the chemical community. While several synthetic routes have been reported, recent advances have focused on developing more efficient and sustainable methods. These methods often involve transition-metal-catalyzed reactions or biocatalytic approaches that minimize waste and improve yields. Such innovations are crucial for ensuring a steady supply of this valuable intermediate while adhering to green chemistry principles.

The growing demand for< strong>Ethyl 2-fluoropyridine-3-carboxylate has also spurred interest in process optimization and scale-up procedures. Industrial manufacturers are continuously refining their synthetic routes to meet the needs of pharmaceutical companies without compromising on quality or cost-effectiveness. This includes optimizing reaction conditions, improving purification techniques, and developing robust analytical methods to ensure product consistency.

In conclusion,< strong>Ethyl 2-fluoropyridine-3-carboxylate (CAS No.< strong>113898-56-9) is a cornerstone compound in modern pharmaceutical synthesis. Its unique structural features make it an invaluable intermediate for developing novel therapeutic agents across various disease areas. As research continues to uncover new applications and synthetic methodologies, this compound will undoubtedly remain at the forefront of drug discovery efforts.

• 117671-02-0(2,6-Difluoro-nicotinic Acid Methyl Ester)
• 116241-59-9(Ethyl 6-fluoronicotinate)
• 446-26-4(Methyl 2-fluoronicotinate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)