Production Method 1

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Sodium hydride ,  18-Crown-6 Solvents: Tetrahydrofuran

Reference

Stereoselective Conjugate Addition of Cyanide

Convine, Nicola Jane, 2005, , ,

Production Method 2

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Acetone ;  20 °C; 20 min, 20 °C

Reference

Synthesis of N-methyl-2-piperidone

Wang, Haiyang; Xu, Haoran; Zang, Na; Wang, Shoukai, Jingxi Huagong Zhongjianti, 2010, 40(1), 52-53

Production Method 3

694-85-9

931-20-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum dioxide Solvents: Acetic acid

Reference

Rearrangement of α-aminoketones during Clemmensen reduction. III. Contraction of a seven-membered ring in the monocyclic series

Leonard, Nelson J.; Barthel, Eric Jr., Journal of the American Chemical Society, 1949, 71, 3098-100

Production Method 4

20845-34-5

931-20-4

Reaction Conditions

1.1 Reagents: Potassium hydroxide ,  Oxygen Solvents: Diethyl ether ;  90 h, rt

Reference

A novel and efficient oxidation of 1,2-amino alcohols to dialkylamides

Garcia-Valverde, Maria; Pedrosa, Rafael; Vicente, Martina, Synlett, 2002, (12), 2092-2094

Production Method 5

21382-30-9

931-20-4

Reaction Conditions

1.1 Reagents: Titanium isopropoxide Solvents: 1,2-Dichloroethane

Reference

Titanium tetraisopropoxide-mediated lactamizations

Mader, Mary; Helquist, Paul, Tetrahedron Letters, 1988, 29(25), 3049-52

Production Method 6

626-67-5

931-20-4

Reaction Conditions

1.1 Reagents: Ethylenediaminetetraacetic acid ,  Mercuric acetate Solvents: Dichloromethane

Reference

Preparation of lactams via oxidation of cyclic, tertiary and secondary amines with mercury(II)-EDTA complex in alkaline medium

Wenkert, Ernest; Angell, E. Charles, Synthetic Communications, 1988, 18(12), 1331-7

Production Method 7

626-67-5

931-20-4

Reaction Conditions

1.1 Reagents: Iodosylbenzene Solvents: Water

Reference

Hypervalent iodine oxidation of amines using iodosobenzene: synthesis of nitriles, ketones and lactams

Moriarty, Robert M.; Vaid, Radhe K.; Duncan, Michael P.; Ochiai, Masahito; Inenaga, Minako; et al, Tetrahedron Letters, 1988, 29(52), 6913-16

Production Method 8

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran

Reference

Reactions of silyllithium reagents with tertiary amides

Mack, Stephen R., 1997, , ,

Production Method 9

6026-86-4

931-20-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Hydrogen Catalysts: Ruthenium Solvents: Methanol ,  Water

Reference

Preparation of lactams

, Japan, , ,

Production Method 10

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Potassium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Toluene ;  24 h, rt

Reference

Asymmetric synthesis and evaluation of α-quaternary chiral lactam derivatives as novel anticancer agents

Lee, Hwanhyuk; Hwang, Su Jung; Jung, Jisung; Hong, Suckchang; Lee, Myungmo; et al, Archives of Pharmacal Research, 2014, 37(10), 1264-1270

Production Method 11

6066-89-3

931-20-4

Reaction Conditions

1.1 Reagents: Water Solvents: Water

Reference

Ruthenium-catalyzed amidation of nitriles with amines. A novel, facile route to amides and polyamides

Murahashi, Shunichi; Naota, Takeshi; Saito, Eiichiro, Journal of the American Chemical Society, 1986, 108(24), 7846-7

Production Method 12

626-67-5

931-20-4

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Gold ,  Silica Solvents: 1,4-Dioxane ,  Water ;  1 min, rt; rt → 100 °C; 4 h, 100 °C

Reference

Aerobic Oxidation of Cyclic Amines to Lactams Catalyzed by Ceria-Supported Nanogold

Dairo, Taiwo O.; Nelson, Nicholas C.; Slowing, Igor I.; Angelici, Robert J.; Woo, L. Keith, Catalysis Letters, 2016, 146(11), 2278-2291

Production Method 13

626-67-5

931-20-4

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Alumina ,  Gold Solvents: Water ;  24 h, 80 °C

Reference

Supported Gold Nanoparticles for Efficient α-Oxygenation of Secondary and Tertiary Amines into Amides

Jin, Xiongjie; Kataoka, Kengo; Yatabe, Takafumi; Yamaguchi, Kazuya; Mizuno, Noritaka, Angewandte Chemie, 2016, 55(25), 7212-7217

Production Method 14

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Ammonium chloride

Reference

N-Alkylation of amines and amides catalyzed by ammonium halides

Kashiwagi, Hiroshi; Enomoto, Saburo, Nippon Kagaku Kaishi, 1980, (2), 279-81

Production Method 15

2751-70-4

931-20-4

Reaction Conditions

1.1 Reagents: 4-Phenyl-3-buten-2-one Catalysts: Dihydrotetrakis(triphenylphosphine)ruthenium Solvents: 1,2-Dimethoxyethane

Reference

Ruthenium-catalyzed transformations of amino alcohols to lactams

Naota, Takeshi; Murahashi, Shunichi, Synlett, 1991, (10), 693-4

Production Method 16

675-20-7

373-68-2

931-20-4

Reaction Conditions

1.1 Solvents: Toluene ;  12 h, 100 °C; 100 °C → rt

Reference

Selective Methylation of Amides, N-Heterocycles, Thiols, and Alcohols with Tetramethylammonium Fluoride

Cheng, Hong-Gang; Pu, Maoping; Kundu, Gourab; Schoenebeck, Franziska, Organic Letters, 2020, 22(1), 331-334

Production Method 17

85462-16-4

120-92-3

931-20-4

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid ,  Triethyl orthoformate Solvents: Ethanol
1.2 -
1.3 Reagents: Sodium iodide Solvents: Acetonitrile

Reference

A simple, one-flask transformation of ketones to N-methyllactams

Hoffman, Robert V.; Salvador, James M., Tetrahedron Letters, 1991, 32(22), 2429-32

Production Method 18

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane

Reference

Fluorination studies using difluoroiodotoluene

Greaney, Michael Francis, 1999, , ,

Production Method 19

68116-79-0

931-20-4

Reaction Conditions

1.1 Reagents: Chlorodimethylsilane ,  Trimethylsilyl triflate

Reference

N-methylation of lactams with the use of silicon-containing reagents

Shipov, A. G.; Kramarova, E. P.; Artamkina, O. B.; Baukov, Yu. I., Zhurnal Obshchei Khimii, 1989, 59(11), 2629-30

Production Method 20

675-20-7

931-20-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  0 °C → 25 °C; 30 min, 25 °C; 25 °C → 0 °C
1.2 0 °C; 0 °C → 25 °C; 16 h, 25 °C

Reference

Origin of High Diastereoselectivity in Reactions of Seven-Membered-Ring Enolates

Lavinda, Olga; Witt, Collin H. ; Woerpel, K. A., Angewandte Chemie, 2022, 61(14),

1-Methylpiperidin-2-one Raw materials

• 1-Methyl-2-piperidinemethanol
• Methanamine, N-[[(4-nitrophenyl)sulfonyl]oxy]-
• 5-(methylamino)pentan-1-ol
• Cyclopentanone
• PENTANENITRILE, 5-(METHYLAMINO)-
• piperidin-2-one
• 1-Methyl-2-pyridone
• Tetramethylammonium fluoride
• 1-METHYLPIPERIDINE
• 1-(chloromethyl)piperidin-2-one
• Pentanoic acid, 5-(methylamino)-
• Methyl 5-oxopentanoate

1-Methylpiperidin-2-one Preparation Products

• 1-Methylpiperidin-2-one (931-20-4)

• 1. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 2. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 3. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 4. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 5. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinones

• 89013-13-8(2-Piperidinone, 1-hexyl-)
• 61891-65-4(2-Piperidinone, methyl-)
• 20368-13-2(1-Nonanone,1-(1-piperidinyl)-)
• 20299-83-6(1-Octanone,1-(1-piperidinyl)-)
• 87639-86-9(Piperidine, 1-(4-amino-1-oxobutyl)-)
• 22422-60-2(1,6-Hexanedione,1,6-di-1-piperidinyl-)
• 15770-38-4(1-Hexanone,1-(1-piperidinyl)-)
• 18494-52-5(1-(piperidin-1-yl)pentan-1-one)
• 22342-28-5(1-Dodecanone,1-(1-piperidinyl)-)
• 5299-66-1(1-(Piperidin-1-yl)decan-1-one)