Production Method 1

4686-14-0

93-98-1

Reaction Conditions

1.1 Catalysts: Water Solvents: Dimethylformamide ;  24 h, 120 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  10 min, rt

Reference

Formation of Amides from Imines via Cyanide-Mediated Metal-Free Aerobic Oxidation

Seo, Hong-Ahn; Cho, Yeon-Ho; Lee, Ye-Sol; Cheon, Cheol-Hong, Journal of Organic Chemistry, 2015, 80(24), 11993-11998

Production Method 2

65-85-0

93-98-1

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium he… Solvents: Tetrahydrofuran ,  Water ;  24 h, pH 10.8, 25 °C

Reference

Evaluation of safe mixed solvents in N-phenylbenzamide synthesis for alteration of hazardous dipolar aprotic solvents in amide drug syntheses

Islam, Tariqul; Sarker, Zaidul Islam Md ; Uddin, Abm helal; Rashid, Shah Samiur; Bin, Liew Kai, Tetrahedron, 2023, 131,

Production Method 3

98-88-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 12 h, rt

Reference

α-Imino Iridium Carbenes from Imidoyl Sulfoxonium Ylides: Application in the One-Step Synthesis of Indoles

Caiuby, Clarice A. D.; de Jesus, Matheus P.; Burtoloso, Antonio C. B., Journal of Organic Chemistry, 2020, 85(11), 7433-7445

Production Method 4

591-50-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: (SP-4-1)-(Acetonitrile)dichloro[1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1,3-dihydro… Solvents: 1,4-Dioxane ;  6 h, 3 atm, 100 °C

Reference

N-heterocyclic carbine palladium complex crystal and its synthesis method and application in preparing amide compound

, China, , ,

Production Method 5

591-50-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: (SP-4-3)-[3′,4′-Bis(4,5-dihydro-4,4-dimethyl-2-oxazolyl-κN3)[1,1′-biphenyl]-4-ol… (solid-supported) Solvents: Acetonitrile ;  rt → 120 °C; 6 h, 100 psi, 120 °C

Reference

Catalytic process for synthesizing ester compounds and amide compounds

, United States, , ,

Production Method 6

98-88-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  0.5 h, 0 °C; 0 °C → rt; 2 h, rt

Reference

Substituted 2,4-diaminopyrimidine compounds as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases

, China, , ,

Production Method 7

7510-33-0

93-98-1

Reaction Conditions

1.1 Reagents: Tetrabutylammonium perchlorate ,  4-Methyl-N,N-bis[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]benzenesulfonamide Solvents: Dimethylformamide ;  25 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  basified, 25 °C

Reference

Electrochemical Reduction of α-Diketones and α-Diimines in the Presence of a Bielectrophilic Substrate: Synthesis of New Aza-Crown Compounds

Medini, Hayet Khemis; Mekni, Nejib Hussein; Aoun, Sami Ben; Boujlel, Khaled, Journal of the Electrochemical Society, 2017, 164(2),

Production Method 8

591-50-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Palladium (Merrifield resin-supported bisoxazoline complexes) ,  3′,4′-Bis(4,5-dihydro-4,4-dimethyl-2-oxazolyl)[1,1′-biphenyl]-4-ol (palladium complexes, Merrifield resin-supported) Solvents: Acetonitrile ;  100 psi, rt → 120 °C; 6 h, 120 °C

Reference

A palladium-bisoxazoline supported catalyst for selective synthesis of aryl esters and aryl amides via carbonylative coupling reactions

Ibrahim, Mansur B.; Suleiman, Rami; Fettouhi, Mohammed; El Ali, Bassam, RSC Advances, 2016, 6(82), 78826-78837

Production Method 9

591-50-4

93-98-1

Reaction Conditions

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: Palladium Solvents: Dimethylacetamide ;  115 °C

Reference

1,8-Diazabicyclo[5.4.0]undec-7-ene

Savoca, Ann C.; Urgaonkar, Sameer, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2006, 1, 1-11

Production Method 10

574-66-3

93-98-1

Reaction Conditions

1.1 Catalysts: Benzenesulfonic acid, 4-ethenyl-, sodium salt (1:1), polymer with diethenylbenze… (neutralized) Solvents: Benzonitrile ;  1 h, 130 °C

Reference

In situ functionalized sulfonic copolymer toward recyclable heterogeneous catalyst for efficient Beckmann rearrangement of cyclohexanone oxime

Li, Difan; Mao, Dan; Li, Jing; Zhou, Yu; Wang, Jun, Applied Catalysis, 2016, 510, 125-133

Production Method 11

93-97-0

93-98-1

Reaction Conditions

1.1 Catalysts: Titania Solvents: Ethanol ;  2.5 h, 25 - 35 °C

Reference

Photocatalytic synthesis of anilides from nitrobenzenes under visible light irradiation: 2 in 1 reaction

Zand, Zahra; Kazemi, Foad; Partovi, Adel, Journal of Photochemistry and Photobiology, 2015, 152, 58-62

Production Method 12

93-58-3

93-98-1

Reaction Conditions

1.1 Catalysts: Phosphoric acid, aluminum iron salt ;  4 h, 92 °C

Reference

Mesoporous iron aluminophosphate: an efficient catalyst for one pot synthesis of amides by ester-amide exchange reaction

Vijayasankar, A. V.; Kathyayini, H.; Tumma, Harikrishna; Nagaraju, N., Ceramic Transactions, 2012, 233, 127-140

Production Method 13

591-50-4

55-21-0

93-98-1

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: N,N′-Dimethylethylenediamine ,  Cuprous iodide Solvents: Dimethyl sulfoxide ;  24 h, 50 °C
1.2 Reagents: Ethyl acetate

Reference

Orthogonal Discrimination among Functional Groups in Ullmann-Type C-O and C-N Couplings

Rovira, Mireia; Soler, Marta; Guell, Imma; Wang, Ming-Zheng; Gomez, Laura; et al, Journal of Organic Chemistry, 2016, 81(17), 7315-7325

Production Method 14

65-85-0

93-98-1

Reaction Conditions

1.1 Reagents: Lithium hydroxide ,  Oxygen Catalysts: Gold (mesoporous alumina-supported) Solvents: Water ;  14 h, rt

Reference

Efficient synthesis of amides and esters from alcohols under aerobic ambient conditions catalyzed by a Au/mesoporous Al2O3 nanocatalyst

Chng, Leng Leng; Yang, Jinhua; Ying, Jackie Y., ChemSusChem, 2015, 8(11), 1916-1925

Production Method 15

98-88-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  0 °C; 2 - 6 h, rt

Reference

Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5

Brusa, Irene; Sondo, Elvira; Pesce, Emanuela; Tomati, Valeria; Gioia, Dario; et al, Journal of Medicinal Chemistry, 2023, 66(14), 9797-9822

Production Method 16

7702-38-7

93-98-1

Reaction Conditions

1.1 Reagents: Sodium formate Solvents: Dimethyl sulfoxide ;  1 h, 120 °C

Reference

Reductive Hydrodehalogenation of Halogenated Carboxylic Acid Derivatives Using a DMSO/HCOONa·2H2O System

Liu, Guyue; Hao, Feiyue; Liang, Lingling; Jin, Zhengneng; Wu, Jiashou, Organic Letters, 2023, 25(15), 2691-2695

Production Method 17

591-50-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine ,  1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: 2211997-02-1 (silica supported; reaction product with Pd2(dba)3·CHCl3) Solvents: Dimethylformamide ,  Toluene ;  3 h, 30 bar, 100 °C

Reference

Double carbonylation of iodoarenes in the presence of reusable palladium catalysts immobilised on supported phosphonium ionic liquid phases

Urban, Bela; Szabo, Peter; Sranko, David; Safran, Gyorgy; Kollar, Laszlo; et al, Molecular Catalysis, 2018, 445, 195-205

Production Method 18

1548-84-1

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dimethylformamide ;  16 h, 100 °C

Reference

A Cross-Coupling Approach to Amide Bond Formation from Esters

Ben Halima, Taoufik; Vandavasi, Jaya Kishore; Shkoor, Mohanad; Newman, Stephen G., ACS Catalysis, 2017, 7(3), 2176-2180

Production Method 19

93-98-1

Reaction Conditions

1.1 Catalysts: Acetic anhydride

Reference

Acetic Anhydride

Zibuck, Regina, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-8

Production Method 20

98-88-4

93-98-1

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 16 h, rt
1.2 Reagents: Water ;  rt

Reference

Oxidative fluorination of N-arylsulfonamides

Buckingham, Faye; Calderwood, Samuel; Checa, Begona ; Keller, Thomas; Tredwell, Matthew; et al, Journal of Fluorine Chemistry, 2015, 180, 33-39

N-Phenylbenzamide Raw materials

• Benzophenone oxime
• Iodobenzene
• Benzamide
• Benzoic acid
• N-(4-Bromophenyl)benzamide
• Methyl benzoate
• N,N''-[(1E,2E)-1,2-diphenylethane-1,2-diylidene]dianiline
• Benzoic anhydride
• Benzoyl chloride
• Benzeneacetonitrile, a-(phenylimino)-
• Pentafluorophenyl Benzoate

N-Phenylbenzamide Preparation Products

• N-Phenylbenzamide (93-98-1)

• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides Aromatic anilides
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 23099-05-0(3-Methylbenzanilide)
• 6876-66-0(Benzamide, 4-methyl-N-(4-methylphenyl)-)
• 87706-91-0(Benzamide, 4-(benzoylamino)-N-[4-(benzoylamino)phenyl]-)
• 88542-59-0(1,4-Benzenedicarboxamide, N-[4-(acetylamino)phenyl]-N'-methyl-)
• 88542-58-9(Benzamide, 4-[[4-(acetylamino)benzoyl]amino]-N-methyl-)
• 955-96-4(4-Amino-N-(4-methylphenyl)benzamide)
• 88542-61-4(1,4-Benzenedicarboxamide, N1-methyl-N4-[4-[(methylamino)carbonyl]phenyl]-)
• 88542-60-3(Benzamide, 4-(acetylamino)-N-[4-(acetylamino)phenyl]-)
• 5181-40-8(p-Terephthalotoluidide)
• 2362-26-7(Benzamide,N,N'-1,4-phenylenebis[4-amino-)