Production Method 1

2085-88-3

93-53-8

Reaction Conditions

1.1 Catalysts: Amberlyst 15 Solvents: Ethyl acetate

Reference

Reaction of styrene oxide in the presence of ion-exchange resins

Kurata, Takeo; Kobayashi, Nobuyuki, Yukagaku, 1989, 38(1), 82-7

Production Method 2

109141-70-0

93-53-8

Reaction Conditions

1.1 Reagents: Water Catalysts: Cupric chloride Solvents: Acetonitrile ;  24 h, 40 °C

Reference

Copper-catalyzed oxidative cleavage of carbon-carbon double bond of enol ethers with molecular oxygen

Tokunaga, Makoto; Shirogane, Yuki; Aoyama, Hiroshi; Obora, Yasushi; Tsuji, Yasushi, Journal of Organometallic Chemistry, 2005, 690(23), 5378-5382

Production Method 3

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Glycine, N3,N5-di-L-phenylalanyl-3,5-diaminobenzoyl-, homopolymer (resin-bound, rhodium complexes)

Reference

A Divergent, Solid-Phase Approach to Dendritic Ligands on Beads. Heterogeneous Catalysis for Hydroformylation Reactions

Arya, Prabhat; Rao, N. Venugopal; Singkhonrat, Jirada; Alper, Howard; Bourque, S. Christine; et al, Journal of Organic Chemistry, 2000, 65(6), 1881-1885

Production Method 4

2085-88-3

93-53-8

1123-85-9

Reaction Conditions

1.1 Catalysts: Iridium(1+), [(1,2,5,6-η)-1,5-cyclooctadiene]hydro[(8-quinolinyl-κN)methyl-κC](t… Solvents: Tetrahydrofuran ;  23 °C; 22 h, 85 °C

Reference

An air-stable cationic iridium hydride as a highly active and general catalyst for the isomerization of terminal epoxides

Humbert, Nicolas; Vyas, Devendra J.; Besnard, Celine; Mazet, Clement, Chemical Communications (Cambridge, 2014, 50(73), 10592-10595

Production Method 5

93-53-8

Reaction Conditions

1.1 Reagents: 2,4,6-Tris[4-(diphenylphosphinyl)-3-methylphenyl]-1,3,5-triazine Catalysts: Dirhodium tetraacetate

Reference

Synthesis of a halo-methylphenylene periphery-functionalized triazine-based dendritic molecule with a 3,3'-dimethyl-biphenyl linker using tris(halo-methylphenylene)triazines as building blocks

Kostas, Ioannis D.; Andreadaki, Fotini J.; Medlycott, Elaine A.; Hanan, Garry S.; Monflier, Eric, Tetrahedron Letters, 2009, 50(16), 1851-1854

Production Method 6

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Dicarbonylrhodium acetylacetonate ,  [(4S)-4,5-Dihydro-4-(1-methylethyl)-2-oxazolyl]methyl 6-(1,1-dimethylethyl)-2-ph… Solvents: Toluene

Reference

Probing new classes of π-acceptor ligands for rhodium catalyzed hydroformylation of styrene

Breit, Bernhard, Journal of Molecular Catalysis A: Chemical, 1999, 143(1-3), 143-154

Production Method 7

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Dicarbonylrhodium acetylacetonate ,  Pyridine, 2-[5-[(diphenylphosphinyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-, (4… Solvents: Benzene

Reference

Hydroformylation of some functionalized olefins catalyzed by rhodium(I) complexes with pydiphos and its P-oxide

Basoli, C.; Botteghi, C.; Cabras, M. A.; Chelucci, G.; Marchetti, M., Journal of Organometallic Chemistry, 1995, 488(1-2),

Production Method 8

93-53-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Dicarbonylrhodium acetylacetonate ,  3,3′,3′′-Phosphinidynetris[pyridine] ,  2416244-04-5 Solvents: Toluene ;  20 min, rt
1.2 Reagents: Hydrogen ;  96 h, 20 bar, 25 °C

Reference

Asymmetric Hydroformylation Using a Rhodium Catalyst Encapsulated in a Chiral Capsule

Jongkind, Lukas J.; Reek, Joost N. H., Chemistry - An Asian Journal, 2020, 15(6), 867-875

Production Method 9

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen ;  16 h, 1000 psi, 50 °C

Reference

Metal supported on dendronized magnetic nanoparticles: highly selective hydroformylation catalysts

Abu-Reziq, Raed; Alper, Howard; Wang, Dashan; Post, Michael L., Journal of the American Chemical Society, 2006, 128(15), 5279-5282

Production Method 10

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Rhodium (polymer-supported phosphine chloride complexes) Solvents: Carbon dioxide ;  7.5 h, 241 bar, 50 °C

Reference

Hydroformylation of styrene in supercritical carbon dioxide with fluoroacrylate polymer supported rhodium catalysts

Kani, Ibrahim; Flores, Roberto; Fackler, John P.; Akgerman, Aydin, Journal of Supercritical Fluids, 2004, 31(3), 287-294

Production Method 11

2085-88-3

93-53-8

Reaction Conditions

1.1 Catalysts: Carbon (mineral acid-treated) ,  Nitric acid Solvents: Ethyl acetate

Reference

Preparation of phenylacetaldehyde and 1,3-dioxolanes from styrene oxide with mineral acid-treated activated carbon catalyst

Kurata, Takeo; Koshiyama, Takao, Yukagaku, 1987, 36(6), 436-40

Production Method 12

109141-70-0

93-53-8

Reaction Conditions

1.1 Reagents: Water ,  Oxygen Catalysts: Cupric chloride Solvents: Acetonitrile ;  24 h, 1 atm, 40 °C

Reference

Oxidative cleavage of CC bond of 2-phenylpropionaldehyde using molecular oxygen

Tokunaga, Makoto; Aoyama, Hiroshi; Shirogane, Yuki; Obora, Yasushi; Tsuji, Yasushi, Catalysis Today, 2006, 117(1-3), 138-140

Production Method 13

21129-06-6

93-53-8

Reaction Conditions

1.1 Catalysts: 1-Butyl-3-methylimidazolium tetrafluoroborate Solvents: Water ,  1-Butyl-3-methylimidazolium tetrafluoroborate ;  3 - 5 h, rt

Reference

Mild and efficient conversion of aldehydes to gem-diacetates using 2nd generation ionic liquids

Yadav, J. S.; Reddy, B. V. S.; Sreedhar, P.; Kondaji, G.; Nagaiah, K., Catalysis Communications, 2008, 9(5), 590-593

Production Method 14

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen ,  (1R,1′R,3aS,3′aS)-1,1′-(1,2-Phenylene)bis[hexahydro-2-phenyl-1H-pyrrolo[1,2-c][1… Catalysts: Dicarbonylrhodium acetylacetonate Solvents: Toluene

Reference

Rhodium-mediated asymmetric hydroformylation with a novel bis(diazaphospholidine) ligand

Breeden, Simon; Cole-Hamilton, David J.; Foster, Douglas F.; Schwarz, Gary J.; Wills, Martin, Angewandte Chemie, 2000, 39(22), 4106-4108

Production Method 15

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Triphenylphosphine ,  Rhodium, [μ-[bis[(2R)-2-(mercapto-κS:κS)propyl] 1,2-benzenedicarboxylato(2-)]]bi… Solvents: Toluene

Reference

Binuclear and polynuclear rhodium complexes containing chiral dithiolate ligands derived from lactic acid

Freixa, Z.; Martin, E.; Gladiali, S.; Bayon, J. C., Applied Organometallic Chemistry, 2000, 14(1), 57-65

Production Method 16

2085-88-3

93-53-8

Reaction Conditions

1.1 Catalysts: Pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,1… Solvents: Chloroform-d ,  Water ;  18 h, 60 °C

Reference

Efficient epoxide isomerization within a self-assembled hexameric organic capsule

Caneva, Thomas; Sperni, Laura; Strukul, Giorgio; Scarso, Alessandro, RSC Advances, 2016, 6(87), 83505-83509

Production Method 17

1123-85-9

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: 1-Butanaminium, N,N,N-tributyl-, ferratetetracosa-μ-oxoundecaoxo[μ12-[phosphato(… (silica composite) Solvents: Acetonitrile ,  Water ;  3 h, reflux

Reference

Synthesis, characterization and catalytic performance of a Fe polyoxometalate/silica composite in the oxidation of alcohols with hydrogen peroxide

Farsani, Mostafa Riahi; Yadollahi, Bahram, Journal of Molecular Catalysis A: Chemical, 2014, 392, 8-15

Production Method 18

2085-88-3

93-53-8

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt → reflux; 2 h, reflux

Reference

Epoxide ring-opening and Meinwald rearrangement reactions of epoxides catalyzed by mesoporous aluminosilicates

Robinson, Mathew W. C.; Davies, A. Matthew; Buckle, Richard; Mabbett, Ian; Taylor, Stuart H.; et al, Organic & Biomolecular Chemistry, 2009, 7(12), 2559-2564

Production Method 19

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Rhodium(1+), [(1,2,5,6-η)-1,5-cyclooctadiene](N,N,N′,N′-tetramethyl-1,2-ethanedi… Solvents: Toluene ;  16 h, 1000 psi, 25 °C

Reference

Ionic diamine rhodium(i) complexes-highly active catalysts for the hydroformylation of olefins

Kim, Jai Jun; Alper, Howard, Chemical Communications (Cambridge, 2005, (24), 3059-3061

Production Method 20

93-53-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Dicarbonylrhodium acetylacetonate ,  Phosphinous acid, diphenyl-, bicyclo[2.2.1]heptane-2,5-diyl ester, (endo,endo)- Solvents: Benzene

Reference

New ligands with a wide bite angle. Efficient catalytic activity in the Rh(I)-catalyzed hydroformylation of olefins

Yamamoto, Keiji; Momose, Satoru; Funahashi, Masakazu; Ebata, Satoshi; Ohmura, Hideaki; et al, Chemistry Letters, 1994, (2), 189-92

2-Phenylpropanal Raw materials

• 1,1-Propanediol,2-phenyl-, 1,1-diacetate
• Benzene, (2-methoxy-1-methylethenyl)-
• α-Methylstyrene Oxide
• 2-Phenyl-1-propanol

2-Phenylpropanal Preparation Products

• 2-Phenylpropanal (93-53-8)
• 2-Phenyl-1-propanol (1123-85-9)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetaldehydes
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 3805-10-5(2-methyl-2-phenylpropanal)
• 34713-70-7(2-PHENYLPROPIONALDEHYDE)
• 947-91-1(Diphenylacetaldehyde (>80%))
• 61136-74-1(2-(4-1,1-Dimethylethylphenyl)propionoic aldehyde)
• 34291-99-1(2-4-(propan-2-yl)phenylpropanal)
• 99-72-9(2-(4-methylphenyl)propanal)
• 27956-35-0(2-(4-Methylphenyl)malonaldehyde)
• 26591-66-2(2-Phenylmalondialdehyde)
• 104488-49-5(Ethyl, 2-oxo-1,1-diphenyl-)
• 849021-24-5(2-(3-Methylphenyl)malondialdehyde)