Production Method 1

1426144-99-1

928839-62-7

Reaction Conditions

1.1 Solvents: Water ;  5 °C; 48 h, 25 - 30 °C

Reference

Method for preparing quinoline derivatives

, China, , ,

Production Method 2

88474-22-0

928839-62-7

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cobalt diacetate ,  Copper oxide (CuO) ,  Tin tetrachloride Solvents: tert-Butanol ;  reflux; 7.5 h, reflux

Reference

Method for preparing 8-quinoline carboxylic acid and its derivatives

, China, , ,

Production Method 3

74316-55-5

928839-62-7

Reaction Conditions

1.1 Reagents: Chromium trioxide ,  Sulfuric acid Solvents: Water ;  2 h, 90 °C

Reference

Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

Malancona, Savina; Donghi, Monica; Ferrara, Marco; Martin Hernando, Jose I.; Pompei, Marco; et al, Bioorganic & Medicinal Chemistry, 2010, 18(8), 2836-2848

Production Method 4

74316-55-5

928839-62-7

Reaction Conditions

1.1 Reagents: Chromium trioxide ,  Sulfuric acid Solvents: Water ;  2 h, 90 °C
1.2 Reagents: Water ;  cooled

Reference

Preparation of quinazolines as antivirals for treatment of hepatitis C viral (HCV) infection.

, World Intellectual Property Organization, , ,

Production Method 5

74316-55-5

928839-62-7

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  0 °C
1.2 Reagents: Chromium trioxide ;  70 °C; 1 h, 70 °C; 2.5 h, 80 °C; 80 °C → rt
1.3 Reagents: Water ;  0 °C

Reference

Preparation of substituted quinolinecarboxylic acids as CCR6 modulators

, World Intellectual Property Organization, , ,

Production Method 6

885267-41-4

928839-62-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Silver nitrate Solvents: Tetrahydrofuran ,  Water ;  10 min, rt; 30 min, rt

Reference

Preparation of heterocyclic carboxamides as modulators of kinase activity

, World Intellectual Property Organization, , ,

Production Method 7

74316-55-5

928839-62-7

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Pyridine ,  Water ;  10 min, 110 °C

Reference

Preparation of quinoline and quinoxaline derivatives as protein tyrosine kinase inhibitors

, World Intellectual Property Organization, , ,

5-Bromoquinoline-8-carboxylic acid Raw materials

• 5-Bromo-8-(bromomethyl)quinoline
• 5-Bromo-8-methylquinoline
• Quinoline, 5-bromo-8-(trichloromethyl)-
• 5-Bromoquinoline-8-carbaldehyde

5-Bromoquinoline-8-carboxylic acid Preparation Products

• 5-Bromoquinoline-8-carboxylic acid (928839-62-7)

• 1. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 2. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 4. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 5. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids

• 860624-90-4(5-Bromo-1H-indole-7-carboxylic acid)
• 892874-34-9(7-Bromoquinoline-3-carboxylic acid)
• 1416438-47-5(5-bromoquinoline-3-carboxylic acid)
• 219763-87-8(4-Bromoquinoline-6-carboxylic acid)
• 110811-31-9(4-Bromo-1H-indole-3-carboxylic acid)
• 798545-30-9(6-Bromoquinoline-3-carboxylic acid)
• 132664-48-3(methyl 4-bromoquinoline-8-carboxylate)
• 64507-38-6(6-Bromoquinoline-8-carboxylic acid)
• 1416438-29-3(4-bromoquinoline-8-carboxylic acid)
• 1378260-46-8(4-Bromoquinoline-3-carboxylic acid)