Production Method 1

138733-50-3

92748-09-9

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic acid Solvents: Toluene ;  3 h, 80 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  rt

Reference

Bronsted Acid Promoted N-Dealkylation of N-Alkyl(sulfon)amides

Gu, Linghui; Wang, Yang; Cheng, Zemin; Sun, Yanan; Gong, Xin; et al, ChemistrySelect, 2021, 6(33), 8839-8842

Production Method 2

92748-09-9

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrochloric acid Solvents: Water
1.2 Reagents: Sodium nitrite Solvents: Water
1.3 Reagents: Hydrazine ,  Sulfur dioxide ,  Cuprous chloride Solvents: Acetic acid ,  Water
1.4 Reagents: Ammonia Solvents: Water

Reference

Efficient, simple procedures for the large-scale preparation of building blocks for angiotensin(II) receptor antagonists

Jendralla, Heiner; Wagner, Adalbert; Mollath, Martina; Wunner, Joachim, Liebigs Annalen, 1995, (7), 1253-7

Production Method 3

6320-02-1

92748-09-9

Reaction Conditions

1.1 Reagents: Ammonium carbamate ,  Iodobenzene diacetate Solvents: Methanol ;  24 h, 25 °C

Reference

Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides

Tota, Arianna; St. John-Campbell, Sahra; Briggs, Edward L.; Estevez, Gala Ogalla; Afonso, Michelle; et al, Organic Letters, 2018, 20(9), 2599-2602

Production Method 4

2905-25-1

92748-09-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane

Reference

Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPARγ derived from the AT1R antagonist, Fimasartan

Choung, Wonken; Jung, Hui Jin; Nam, Eun Hye; Yang, Deokmo; Yoo, Byoungwook; et al, Bioorganic & Medicinal Chemistry Letters, 2018, 28(19), 3155-3160

Production Method 5

2905-25-1

92748-09-9

Reaction Conditions

1.1 Reagents: Phthalimide ,  Tributylphosphine ,  N,N,N′,N′-Tetramethylazodicarboxamide Solvents: Dichloromethane ,  Tetrahydrofuran
1.2 Reagents: Hydrazine Solvents: Tetrahydrofuran
1.3 Reagents: 4-(Dimethylamino)pyridine ,  Diisopropylethylamine Solvents: Dichloromethane ,  Tetrahydrofuran

Reference

Solid-phase synthesis of acyl biarylsulfonamides

Xiong, Yusheng; Klopp, John; Chapman, Kevin T., Tetrahedron Letters, 2001, 42(48), 8423-8427

Production Method 6

92748-09-9

Reaction Conditions

Reference

Preparation of 3-[[2'-(ureidosulfonyl)biphenyl-4-yl]methyl]imidazo[4,5-b]pyridines and analogs as angiotensin II antagonists

, European Patent Organization, , ,

Production Method 7

92748-09-9

Reaction Conditions

Reference

Preparation of N-[(carbamoylaminosulfonyl)biphenylylmethyl]imidazoles as angiotensin II receptor antagonists

, European Patent Organization, , ,

Production Method 8

2905-25-1

92748-09-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Water ;  rt; 16 h, rt

Reference

Iridium-Catalyzed C-H Activation and Deuteration of Primary Sulfonamides: An Experimental and Computational Study

Kerr, William J.; Reid, Marc; Tuttle, Tell, ACS Catalysis, 2015, 5(1), 402-410

Production Method 9

2905-25-1

92748-09-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Tetrahydrofuran ;  rt; 2.5 h, rt

Reference

Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates

Tilby, Michael J.; Dewez, Damien F.; Pantaine, Loic R. E.; Hall, Adrian; Martinez-Lamenca, Carolina; et al, ACS Catalysis, 2022, 12(10), 6060-6067

Production Method 10

6320-02-1

92748-09-9

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Ammonia ,  Oxygen Catalysts: Iodine Solvents: Acetonitrile ,  Water ;  16 h, rt → 100 °C; 100 °C → rt
1.2 Reagents: Water ;  rt

Reference

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

Feng, Jian-Bo; Wu, Xiao-Feng, Organic & Biomolecular Chemistry, 2016, 14(29), 6951-6954

Production Method 11

2905-25-1

92748-09-9

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Chloroform ;  0 °C; 30 min, 0 °C

Reference

Lewis Acid Catalyzed Cascade Reaction of 3-(2-Benzenesulfonamide)propargylic Alcohols to Spiro[indene-benzosultam]s

Sun, Lang; Zhu, Yuanxun; Wang, Jing; Lu, Ping; Wang, Yanguang, Organic Letters, 2015, 17(2), 242-245

Production Method 12

2905-25-1

92748-09-9

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Acetonitrile ,  Water ;  0 °C; 1 h, rt

Reference

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(9), 2222-2225

Production Method 13

92748-09-9

Reaction Conditions

Reference

Biphenylylimidazopyridine derivatives, their uses for treatment of cardiovascular diseases, their preparation, and their intermediates

, Japan, , ,

Production Method 14

92748-09-9

Reaction Conditions

Reference

Imidazole derivatives having biphenylsulfonylurea or biphenylsulfonylurethane side chains, process for their production and use thereof

, European Patent Organization, , ,

2-Bromobenzenesulfonamide Raw materials

• 2-Bromobenzene-1-sulfonyl chloride
• 2-Bromo-N-tert-butylbenzenesulfonamide
• 2-Bromo-benzenethiol

2-Bromobenzenesulfonamide Preparation Products

• 2-Bromobenzenesulfonamide (92748-09-9)

• 1. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 4. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 5. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293

• 89599-01-9(3-Bromobenzenesulfonamide)
• 98192-14-4(2-Bromo-N-methylbenzenesulfonamide)
• 56919-21-2(2-bromo-5-methylbenzene-1-sulfonamide)
• 701-34-8(4-Bromobenzenesulfonamide)
• 42111-84-2(sodium ((4-bromophenyl)sulfonyl)amide)
• 1261438-65-6(2-bromo-4-iodobenzene-1-sulfonamide)
• 1243282-97-4(2-bromo-4-hydroxybenzenesulfonamide)
• 39235-31-9(3,5-dibromobenzene-1-sulfonamide)
• 351003-60-6(2-bromo-4-fluorobenzene-1-sulfonamide)
• 7467-11-0(2,5-Dibromobenzenesulfonamide)