Production Method 1

2905-24-0

89599-01-9

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Acetonitrile ,  Water ;  0 °C; 1 h, rt

Reference

Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase

Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(9), 2222-2225

Production Method 2

2905-24-0

89599-01-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide ;  3 - 4 h, 0 °C

Reference

Unexpected C=N bond formation via NaI-catalyzed oxidative de-tetra-hydrogenative cross-couplings between N,N-dimethyl aniline and sulfamides

Zheng, Yang; Mao, Jincheng; Chen, Jie; Rong, Guangwei; Liu, Defu; et al, RSC Advances, 2015, 5(62), 50113-50117

Production Method 3

308283-47-8

89599-01-9

Reaction Conditions

1.1 Reagents: Aluminum ,  Iodine Solvents: Acetonitrile ;  18 h, 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

Sang, Dayong ; Dong, Bingqian; Liu, Yunfeng; Tian, Juan, Journal of Organic Chemistry, 2022, 87(5), 3586-3595

Production Method 4

6320-01-0

89599-01-9

Reaction Conditions

1.1 Reagents: Ammonium carbamate ,  Iodobenzene diacetate Solvents: Methanol ;  24 h, rt

Reference

Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates

Tilby, Michael J.; Dewez, Damien F.; Pantaine, Loic R. E.; Hall, Adrian; Martinez-Lamenca, Carolina; et al, ACS Catalysis, 2022, 12(10), 6060-6067

Production Method 5

2905-24-0

89599-01-9

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Dichloromethane ,  Water ;  0 °C → rt; 2 h, rt

Reference

Design and Synthesis of Benzenesulfonamide Derivatives as Potent Anti-Influenza Hemagglutinin Inhibitors

Tang, Guozhi; Lin, Xianfeng; Qiu, Zongxing; Li, Wentao; Zhu, Lei; et al, ACS Medicinal Chemistry Letters, 2011, 2(8), 603-607

3-Bromobenzenesulfonamide Raw materials

• 3-Bromothiophenol
• 3-Bromo-N-tert-butylbenzenesulfonamide
• 3-Bromobenzenesulfonyl chloride

3-Bromobenzenesulfonamide Preparation Products

• 3-Bromobenzenesulfonamide (89599-01-9)

• 1. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
• 2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 3. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 4. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 5. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Comprehensive Overview of 3-Bromobenzenesulfonamide (CAS No. 89599-01-9): Properties, Applications, and Industry Insights

3-Bromobenzenesulfonamide (CAS No. 89599-01-9) is a specialized organic compound widely utilized in pharmaceutical intermediates, agrochemical synthesis, and material science research. This brominated sulfonamide derivative exhibits unique chemical properties, making it a valuable building block for advanced molecular designs. With the growing demand for high-purity sulfonamide compounds in drug discovery, researchers are increasingly focusing on optimizing its synthetic pathways and exploring novel applications.

The molecular structure of 3-Bromobenzenesulfonamide features a benzene ring substituted with both a bromine atom at the meta position and a sulfonamide functional group. This configuration contributes to its enhanced reactivity in nucleophilic substitution reactions, particularly in the development of biologically active molecules. Recent studies highlight its potential as a key intermediate for antimicrobial agents and enzyme inhibitors, aligning with current industry trends toward targeted therapeutics.

In material science, 89599-01-9 demonstrates promising characteristics for polymer modification and surface functionalization. Its ability to form stable hydrogen bonds through the sulfonamide group makes it suitable for creating advanced functional materials with tailored properties. Researchers are investigating its role in developing self-assembling monolayers and molecular recognition systems, addressing the growing need for smart materials in nanotechnology applications.

The synthesis of 3-Bromobenzenesulfonamide typically involves bromination of benzenesulfonamide derivatives under controlled conditions. Modern green chemistry approaches are being applied to improve yield and reduce environmental impact, responding to the pharmaceutical industry's sustainability initiatives. Analytical techniques such as HPLC purity testing and spectroscopic characterization ensure compliance with stringent quality standards required for research and industrial applications.

Market analysis indicates rising demand for halogenated sulfonamides like 3-Bromobenzenesulfonamide, driven by expanding applications in medicinal chemistry and material engineering. Regulatory considerations emphasize proper handling procedures and storage conditions to maintain compound stability. As research continues to uncover new potential uses, this compound remains at the forefront of specialty chemical innovation, offering solutions for complex scientific challenges across multiple disciplines.

• 92748-09-9(2-Bromobenzenesulfonamide)
• 56919-16-5(5-Bromo-2-methylbenzenesulfonamide)
• 701-34-8(4-Bromobenzenesulfonamide)
• 210824-69-4(3-Bromo-4-methylbenzenesulfonamide)
• 42111-84-2(sodium ((4-bromophenyl)sulfonyl)amide)
• 39235-31-9(3,5-dibromobenzene-1-sulfonamide)
• 153435-79-1(3-Bromo-N-methylbenzenesulfonamide)
• 89862-26-0(3-Bromobenzenesulfonohydrazide)
• 1984-32-3(4-bromo-N-hydroxybenzenesulfonamide)
• 7467-11-0(2,5-Dibromobenzenesulfonamide)