- IL4I1 inhibitors and methods of use, World Intellectual Property Organization, , ,
Cas no 924633-09-0 (3-Benzyl-6-bromoquinoline-2(1H)-one)
924633-09-0 structure
Product Name:3-Benzyl-6-bromoquinoline-2(1H)-one
CAS No:924633-09-0
MF:C16H12BrNO
MW:314.1765832901
MDL:MFCD28124969
CID:4659824
PubChem ID:58180829
Update Time:2024-12-09
3-Benzyl-6-bromoquinoline-2(1H)-one Chemical and Physical Properties
Names and Identifiers
-
- 6-Bromo-3-(phenylmethyl)-2(1H)-quinolinone
- NYAOVIBBTKTYMI-UHFFFAOYSA-N
- 3-Benzyl-6-bromoquinoline-2(1H)-one
- 3-Benzyl-6-bromo-1H-quinoline-2-one
- 2(1H)-Quinolinone,6-bromo-3-(phenylmethyl)-
- 2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)-
- 6-Bromo-3-(phenylmethyl)-2(1H)-quinolinone (ACI)
- 3-Benzyl-6-bromo-1H-quinolin-2-one
- 3-Benzyl-6-bromo-2(1H)-quinolinone
- ZLB63309
- SCHEMBL6521139
- DB-099126
- AKOS037650742
- CS-15246
- CS-0011156
- 924633-09-0
- AT-417/43485049
- C13204
-
- MDL： MFCD28124969
- Inchi： 1S/C16H12BrNO/c17-14-6-7-15-12(10-14)9-13(16(19)18-15)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H,18,19)
- InChI Key： NYAOVIBBTKTYMI-UHFFFAOYSA-N
- SMILES： O=C1C(CC2C=CC=CC=2)=CC2C(=CC=C(C=2)Br)N1
Computed Properties
- Exact Mass: 313.01023g/mol
- Monoisotopic Mass: 313.01023g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 19
- Rotatable Bond Count: 2
- Complexity: 373
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 29.1
- XLogP3: 4
Experimental Properties
- Density: 1.5±0.1 g/cm3
- Melting Point: NA
- Boiling Point: 494.3±45.0 °C at 760 mmHg
- Flash Point: 252.8±28.7 °C
- Vapor Pressure: 0.0±1.3 mmHg at 25°C
3-Benzyl-6-bromoquinoline-2(1H)-one Security Information
- Hazard Statement： CAUTION: May irritate eyes, skin
- Safety Instruction： CAUT
3-Benzyl-6-bromoquinoline-2(1H)-one Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| eNovation Chemicals LLC | D772735-100mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98+% | 100mg |
$265 | 2024-06-06 | |
| eNovation Chemicals LLC | D772735-250mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98+% | 250mg |
$420 | 2024-06-06 | |
| eNovation Chemicals LLC | D772735-1g |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98+% | 1g |
$820 | 2024-06-06 | |
| Aaron | AR00IMQI-100mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 100mg |
$220.00 | 2025-02-10 | |
| Aaron | AR00IMQI-250mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 250mg |
$366.00 | 2025-02-10 | |
| Aaron | AR00IMQI-1g |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 1g |
$731.00 | 2025-02-10 | |
| 1PlusChem | 1P00IMI6-100mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 100mg |
$253.00 | 2024-04-20 | |
| 1PlusChem | 1P00IMI6-250mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 250mg |
$408.00 | 2024-04-20 | |
| A2B Chem LLC | AI68174-100mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 100mg |
$282.00 | 2024-07-18 | |
| A2B Chem LLC | AI68174-250mg |
2(1H)-Quinolinone, 6-bromo-3-(phenylmethyl)- |
924633-09-0 | 98% | 250mg |
$463.00 | 2024-07-18 |
3-Benzyl-6-bromoquinoline-2(1H)-one Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran , Water ; 16 h, rt → 80 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ; < 15 °C; 15 °C → 40 °C; 40 °C
1.2 overnight, 80 °C
1.3 Reagents: Water ; cooled
1.2 overnight, 80 °C
1.3 Reagents: Water ; cooled
Reference
- Synthesis of 6-bromo-3-(chlorophenylmethyl)-2-methoxyquinolineCai, Zhi-qiang; Sun, Tie-min, Hecheng Huaxue, 2009, 17(5), 640-641
Production Method 3
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Acetone ; 15 min, reflux
Reference
- Trifluoroacetic acid: a more effective and efficient reagent for the synthesis of 3-arylmethylene-3,4-dihydro-1H-quinolin-2-ones and 3-arylmethyl-2-aminoquinolines from Baylis-Hillman derivatives via Claisen rearrangementPathak, Richa; Madapa, Sudharshan; Batra, Sanjay, Tetrahedron, 2007, 63(2), 451-460
Production Method 4
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Acetone ; 15 - 20 min, reflux
Reference
- Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivatives as antimycobacterial agents and their preparation, pharmaceutical compositions and use in the treatment of mycobacterial infections, World Intellectual Property Organization, , ,
Production Method 5
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Water ; overnight, reflux
Reference
- Preparation of quinoline derivatives as antibacterial agents, World Intellectual Property Organization, , ,
3-Benzyl-6-bromoquinoline-2(1H)-one Raw materials
- 3-Benzyl-6-bromo-2-methoxyquinoline
- N-(4-Bromophenyl)-benzenepropanamide
- 3-Benzyl-6-bromo-2-chloroquinoline
- 2(1H)-Quinolinone, 6-bromo-3,4-dihydro-3-(phenylmethylene)-
3-Benzyl-6-bromoquinoline-2(1H)-one Preparation Products
3-Benzyl-6-bromoquinoline-2(1H)-one Related Literature
-
Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
-
Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
-
M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
-
Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
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