Production Method 1

1615215-44-5

923-27-3

Reaction Conditions

1.1 Catalysts: Ammonium hydroxide Solvents: Methanol ,  Water ;  rt

Reference

Chemical dynamic kinetic resolution and S/R interconversion of unprotected α-amino acids

Takeda, Ryosuke; Kawamura, Akie; Kawashima, Aki; Sato, Tatsunori; Moriwaki, Hiroki; et al, Angewandte Chemie, 2014, 53(45), 12214-12217

Production Method 2

923-27-3

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  6 h, rt

Reference

Selective synthesis applying amino acids with basic side chains as peptide precursors

Kuhler, Jeanne L.; Brooks, Robey T.; Helms, Whitney K.; Hodge, Monica; Holly, Krystal D.; et al, African Journal of Pure and Applied Chemistry, 2009, 3(6), 108-115

Production Method 3

923-27-3

Reaction Conditions

1.1 Reagents: Ammonia Catalysts: Copper, [tris(3,5-dimethyl-1H-pyrazolato-κN1)hydroborato(1-)-κN2,κN2′,κN2′′]- ,  (2R)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-3,3-dimethyl… Solvents: tert-Butyl methyl ether ;  10 h, 40 °C
1.2 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  16 h, rt

Reference

Enantioselective synthesis of amino acids from ammonia

Li, Mao-Lin ; Pan, Jia-Bin; Zhou, Qi-Lin, Nature Catalysis, 2022, 5(6), 571-577

Production Method 4

70-54-2

923-27-3

Reaction Conditions

1.1 Solvents: Water ;  72 h, 30 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3
1.3 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, rt

Reference

Preparation of D-amino acid via enzymic resolution of DL-amino acid

, China, , ,

Production Method 5

29070-06-2

923-27-3

Reaction Conditions

Reference

D-α-Amino acids

, Federal Republic of Germany, , ,

Production Method 6

56-87-1

923-27-3

Reaction Conditions

1.1 Reagents: Sodium chloride Catalysts: Lysine racemase Solvents: Water ;  pH 7.0, 37 °C

Reference

Gel type biocatalyst, preparation method, and application in D-lysine production

, China, , ,

Production Method 7

56-87-1

923-27-3

Reaction Conditions

1.1 Catalysts: Lysine racemase ;  rt

Reference

Functional expression of L-lysine α-oxidase from Scomber japonicus in Escherichia coli for one-pot synthesis of L-pipecolic acid from DL-lysine

Tani, Yasushi; Miyake, Ryoma; Yukami, Ryoichi; Dekishima, Yasumasa; China, Hideyasu; et al, Applied Microbiology and Biotechnology, 2015, 99(12), 5045-5054

Production Method 8

70671-54-4

923-27-3

Reaction Conditions

1.1 18 - 20 h, 42 °C
1.2 Reagents: Trifluoroacetic acid Solvents: Acetonitrile ;  42 °C

Reference

Enantioselective enzymatic cleavage of N-benzyloxycarbonyl groups

Patel, Ramesh N.; Nanduri, Venkata; Brzozowski, David; McNamee, Clyde; Banerjee, Amit, Advanced Synthesis & Catalysis, 2003, 345, 830-834

Production Method 9

70-54-2

923-27-3

Reaction Conditions

Reference

General evaluation and application to trace analysis of a chiral column for ligand-exchange chromatography

Kiniwa, Hideaki; Baba, Yuka; Ishida, Tomoko; Katoh, Hiromasa, Journal of Chromatography, 1989, 461, 397-405

Production Method 10

29070-06-2

923-27-3

Reaction Conditions

Reference

Enzymic production of D-amino acids from 5-substituted hydantoins. Part II. Optimal conditions for the enzymic production of D-amino acids from the corresponding 5-substituted hydantoins

Yokozeki, Kenzo; Nakamori, Shigeru; Yamanaka, Shigeru; Eguchi, Chikahiko; Mitsugi, Koji; et al, Agricultural and Biological Chemistry, 1987, 51(3), 715-19

Production Method 11

70-54-2

923-27-3

Reaction Conditions

1.1 Reagents: (αS)-α-Methylbenzenemethanesulfonic acid ,  α-Methyl-4-nitrobenzenemethanesulfonic acid Solvents: Methanol ,  Water ;  5 h, reflux; reflux → 75 °C
1.2 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  pH 9.74; 1 h

Reference

Process for preparation of optically active amino acids

, China, , ,

Production Method 12

657-27-2

923-27-3

Reaction Conditions

1.1 105 h, 135 °C

Reference

Greener approach to leather tanning process: D-Lysine aldehyde as novel tanning agent for chrome-free tanning

Krishnamoorthy, Ganesan; Sadulla, Sayeed; Sehgal, Praveen Kumar; Mandal, Asit Baran, Journal of Cleaner Production, 2013, 42, 277-286

Production Method 13

70-53-1

923-27-3

Reaction Conditions

1.1 Solvents: Water

Reference

Preparation of dl-lysine linear dimer for quality control of aspirin-dl-lysine

, China, , ,

Production Method 14

70-54-2

923-27-3

Reaction Conditions

1.1 Reagents: Phenylacetyl chloride ,  Sodium hydroxide Solvents: Water ;  pH 8 - 10, 10 °C; 2 h, 10 °C; 6 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1 - 2
1.3 Reagents: Sodium hydroxide ,  Penicillin amidase Solvents: Water ;  12 h, 30 °C
1.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 1 - 2; 5 h, 120 °C
1.5 Reagents: Ammonia Solvents: Water ;  overnight, pH 5.74, 4 °C

Reference

Method for preparing D-amino acid with immobilized penicillin acylase as catalyst

, China, , ,

Production Method 15

56-87-1

923-27-3

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 3-Hydroxy-2-methyl-5-[(octyloxy)methyl]-4-pyridinecarboxaldehyde Solvents: Water ;  18 h, 20 - 25 °C

Reference

Preparation of racemic α-amino acid standards for accurate mass spectrometric analysis via racemization catalyzed by a hydrophobic pyridoxal derivative

Harada, Masashi ; Shimbo, Kazutaka; Karakawa, Sachise, Talanta, 2021, 234,

Production Method 16

70-54-2

923-27-3

Reaction Conditions

1.1 Catalysts: Zinc nitrate (complexes with acrylic acid-styrene-Me methacrylate copolymer) ,  Acrylic acid-methyl methacrylate-styrene copolymer (complexes with zinc nitrate) Solvents: Water ;  12 h, rt

Reference

Chiral organic metal skeleton hollow nanosphere and preparation method thereof

, China, , ,

Production Method 17

87-69-4

923-27-3

923-27-3

Reaction Conditions

1.1 Reagents: Calcium hydroxide Solvents: Water ;  rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 5.5 - 6

Reference

Process for preparation of D-lysine hydrochloride

, China, , ,

Production Method 18

923-27-3

35963-20-3

923-27-3

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  pH 0.5 - 1.5

Reference

Process for preparation of D-lysine hydrochloride

, China, , ,

Production Method 19

1155-64-2

923-27-3

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid Solvents: Acetonitrile ;  18 - 20 h, 42 °C

Reference

Enzymic deprotection of amines and hydroxides

, World Intellectual Property Organization, , ,

Production Method 20

10606-14-1

923-27-3

Reaction Conditions

1.1 Reagents: NADH ,  D-Alanine ,  D-Lactic acid Catalysts: D-Amino acid aminotransferase Solvents: Water ;  pH 8.3, 37 °C

Reference

Preparation of enantiomerically pure D-amino acids by fermentative with transgenic cells

, United States, , ,

D-Lysine Raw materials

• H-Lys(Z)-OH
• Z-D-Lys-oh
• L(+)-Tartaric acid
• DL-Lysine
• D-Lysine
• 5-(4-aminobutyl)imidazolidine-2,4-dione
• Nickel, [N-[[5-chloro-2-[[2-[(11bS)-3,5-dihydro-4H-dinaphth[2,1-c:1',2'-e]azepin-4-yl-κN]acetyl]amino-κN]phenyl]phenylmethylene]-D-lysinato(2-)-κN2,κO1]-, (SP-4-4)-
• lysine hydrochloride
• (1R)-(-)-10-Camphorsulfonic Acid
• L-Lysine hydrochloride
• L-Lysine
• Hexanoic acid, 6-amino-2-oxo-

D-Lysine Preparation Products

• D-Lysine (923-27-3)

• 1. Alternative synthesis of the anti-baldness compound RU58841?
  RSC Adv., 2014,4, 14143-14148
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  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
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• 5. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives D-alpha-amino acids

• 100680-17-9(Octadecanoic acid, 2-amino-, (R)-)
• 1202063-56-6(L-Glutamic Acid-13C5,15N)
• 247028-11-1(DEUTEROLYSIN)
• 6899-05-4(GLUTAMIC ACID)
• 108437-96-3((2S)-2-amino-8-hydroxyoctanoic acid)
• 6152-91-6(DL-NORVALINE, 5-HYDROXY-)
• 115791-71-4(Eicosanoic acid, 2-amino-)
• 1188-04-1(Heptanoic acid, 2-amino-)
• 113417-78-0(Decanoic acid, 2,10-diamino-)
• 113417-80-4(Dodecanoic acid, 2,12-diamino-)