Production Method 1

40473-01-6

921630-14-0

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  rt → -70 °C; 15 min, -70 °C; < -65 °C; 30 min, -70 °C
1.2 20 min, < -70 °C; 40 min, -70 °C; -78 °C → rt

Reference

Preparation of primary amines as renin inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

40473-01-6

921630-14-0

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ,  Hexane ;  15 min, -70 °C; < -65 °C; 30 min, -70 °C
1.2 20 min, < -70 °C; 40 min, -70 °C; -70 °C → rt
1.3 Reagents: Sodium hydroxide Solvents: Water

Reference

Preparation of secondary amines as renin inhibitors

, World Intellectual Property Organization, , ,

Production Method 3

40473-01-6

921630-14-0

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  15 min, -70 °C; 30 min, -70 °C
1.2 20 min, -70 °C; 40 min, -70 °C; -70 °C → rt
1.3 Reagents: Sodium hydroxide Solvents: Water

Reference

Preparation of benzenepropanamides as non-peptidic renin inhibitors

, World Intellectual Property Organization, , ,

Production Method 4

40473-01-6

921630-14-0

Reaction Conditions

1.1 Reagents: Diisopropylamine ,  Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  30 min, -5 °C; -5 °C → -70 °C
1.2 Solvents: Tetrahydrofuran ;  15 min, -70 °C; < -65 °C; 30 min, -70 °C
1.3 20 min, < -70 °C; 40 min, -70 °C; -70 °C → rt
1.4 Reagents: Sodium hydroxide Solvents: Water ;  rt

Reference

New amines as renin inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cardiovascular and renal diseases

, World Intellectual Property Organization, , ,

2-bromo-5-chloropyridine-4-carbaldehyde Raw materials

• 2-Bromo-5-chloropyridine

2-bromo-5-chloropyridine-4-carbaldehyde Preparation Products

• 2-bromo-5-chloropyridine-4-carbaldehyde (921630-14-0)

• 1. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 2. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 3. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 5. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Comprehensive Overview of 2-Bromo-5-chloropyridine-4-carbaldehyde (CAS No. 921630-14-0)

2-Bromo-5-chloropyridine-4-carbaldehyde (CAS No. 921630-14-0) is a highly versatile heterocyclic aldehyde widely utilized in pharmaceutical, agrochemical, and material science research. This compound, featuring both bromo and chloro substituents on a pyridine ring, serves as a critical building block for synthesizing complex molecules. Its unique structure enables diverse functionalization, making it invaluable in cross-coupling reactions, catalysis, and drug discovery.

The growing demand for halogenated pyridine derivatives like 2-bromo-5-chloropyridine-4-carbaldehyde is driven by their role in developing targeted therapies and sustainable agrochemicals. Researchers frequently search for "pyridine aldehyde applications" or "CAS 921630-14-0 synthesis," reflecting its relevance in modern chemistry. Its compatibility with palladium-catalyzed reactions (e.g., Suzuki-Miyaura couplings) aligns with trends toward green chemistry and atom-efficient methodologies.

From a technical perspective, 921630-14-0 exhibits notable stability under inert atmospheres, though storage at low temperatures is recommended to preserve its aldehyde functionality. Analytical data (e.g., ¹H NMR, HPLC) confirm high purity (>98%), meeting standards for high-throughput screening and preclinical studies. Recent patents highlight its use in kinase inhibitor development, addressing diseases like cancer and inflammation.

Environmental and regulatory considerations for 2-bromo-5-chloropyridine-4-carbaldehyde emphasize proper waste disposal due to its halogen content. However, its low acute toxicity (per OECD guidelines) facilitates safe handling in controlled settings. Innovations in biodegradable catalysts further enhance its appeal for sustainable synthesis.

In material science, this compound contributes to organic electronic materials, particularly in OLED and photovoltaic applications. Its electron-withdrawing groups improve charge transport, a hot topic in "organic semiconductor design" searches. Suppliers often provide custom synthesis services to meet niche demands, underscoring its commercial importance.

Future research directions may explore 921630-14-0 in AI-assisted drug design or flow chemistry systems, aligning with industry 4.0 trends. Its balanced reactivity and scalability position it as a staple in medicinal chemistry libraries, answering frequent queries like "how to modify pyridine aldehydes" or "CAS 921630-14-0 suppliers."

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