Production Method 1

1257310-83-0

92146-82-2

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethylformamide ;  8 h, 45 °C

Reference

Carbamic acid 2-trimethylsilylethyl ester as a new ammonia equivalent for palladium-catalyzed amination of aryl halides

Mullick, Dibakar; Anjanappa, Prakash; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam, Tetrahedron Letters, 2010, 51(46), 5984-5987

Production Method 2

1045771-49-0

92146-82-2

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethylformamide ;  36 h, 130 °C

Reference

2-(Trimethylsilyl)ethanesulfonyl amide as a new ammonia equivalent for palladium-catalyzed amination of aryl halides

Anjanappa, Prakash; Mullick, Dibakar; Selvakumar, Kumaravel; Sivakumar, Manickam, Tetrahedron Letters, 2008, 49(31), 4585-4587

Production Method 3

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, 1 atm, rt

Reference

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Shindo, Naoya ; Fuchida, Hirokazu; Sato, Mami; Watari, Kosuke; Shibata, Tomohiro; et al, Nature Chemical Biology, 2019, 15(3), 250-258

Production Method 4

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  4 h, 60 psi, 23 °C

Reference

Selective Urokinase-Type Plasminogen Activator Inhibitors. 1-(7-Sulfonamidoisoquinolinyl)guanidines

Fish, Paul V.; Barber, Christopher G.; Brown, David G.; Butt, Richard; Collis, Michael G.; et al, Journal of Medicinal Chemistry, 2007, 50(10), 2341-2351

Production Method 5

92146-82-2

Reaction Conditions

Reference

Preparation of 1,5-benzodiazepine derivatives as CCK-A receptor agonists

, World Intellectual Property Organization, , ,

Production Method 6

92146-82-2

Reaction Conditions

Reference

Preparation of pyridone- and pyrimidoneacetamides and their intermediates and their pharmaceutical use as chymase inhibitors

, Japan, , ,

Production Method 7

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Iron ,  Ammonium chloride Solvents: Ethanol ,  Water ;  2 h, 95 °C

Reference

Innovative Multipodal Ligands Derived from Troeger's Bases for the Sensitization of Lanthanide(III) Luminescence

Trupp, Leandro ; Bruttomesso, Andrea C.; Varde, Mariana; Eliseeva, Svetlana V. ; Ramirez, Javier A.; et al, Chemistry - A European Journal, 2020, 26(70), 16900-16909

Production Method 8

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  rt

Reference

Rational Design of Substituted Diarylureas: A Scaffold for Binding to G-Quadruplex Motifs

Drewe, William C.; Nanjunda, Rupesh; Gunaratnam, Mekala; Beltran, Monica; Parkinson, Gary N.; et al, Journal of Medicinal Chemistry, 2008, 51(24), 7751-7767

Production Method 9

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  3.5 h

Reference

Ureylene derivatives as DNA oligonucleotide ligands and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 10

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Ethanol ,  Water ;  2 h, 50 °C

Reference

Preparation of hydroxyethylamine derivatives for the treatment of Alzheimer's disease

, World Intellectual Property Organization, , ,

Production Method 11

24424-99-5

121-92-6

92146-82-2

Reaction Conditions

1.1 Reagents: 4-(Dimethylamino)pyridine Solvents: tert-Butanol
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol

Reference

New selenyl linker for solid-phase synthesis of dehydropeptides

Nakamura, Kazuhiko; Ohnishi, Yuki; Horikawa, Eiji; Konakahara, Takeo; Kodaka, Masato; et al, Tetrahedron Letters, 2003, 44(29), 5445-5448

Production Method 12

16537-17-0

92146-82-2

Reaction Conditions

1.1 Reagents: Ammonia ,  Tripotassium phosphate Catalysts: Copper ,  2633071-98-2 Solvents: Dimethyl sulfoxide ,  Water ;  48 h, 80 °C

Reference

Porous polymeric ligand promoted copper-catalyzed C-N coupling of (hetero)aryl chlorides under visible-light irradiation

Wang, Erfei; Chen, Kaixuan; Chen, Yinan; Zhang, Jiawei; Lin, Xinrong; et al, Science China: Chemistry, 2021, 64(1), 17-21

Production Method 13

69038-74-0

92146-82-2

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide ,  Rink Amide AM Catalysts: Tris(dibenzylideneacetone)dipalladium ,  BINAP Solvents: tert-Butanol ,  1,4-Dioxane ;  18 - 20 h, 80 °C
1.2 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  45 min, rt

Reference

Palladium-Catalyzed Amination of Aryl Halides on Solid Support

Weigand, Klaus; Pelka, Sylvie, Organic Letters, 2002, 4(26), 4689-4692

Production Method 14

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  4 h, 60 psi, 23 °C

Reference

Preparation of guanidinoisoquinolines as urokinase inhibitors

, United States, , ,

Production Method 15

58656-99-8

92146-82-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  4 h, 60 psi, 23 °C

Reference

Preparation of isoquinolinylguanidines as urokinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 16

92146-82-2

Reaction Conditions

Reference

Preparation of novel selenyl linkers and their use as intermediates for double bond-containing compounds

, Japan, , ,

Production Method 17

92146-82-2

Reaction Conditions

Reference

Preparation of 1,4-benzodiazepin-2-one-1-acetamides as cholecystokinin-A receptor agonists

, World Intellectual Property Organization, , ,

Production Method 18

92146-82-2

Reaction Conditions

Reference

Preparation of CCK or gastrin modulating 5-heterocyclyl-1,5-benzodiazepinediones

, World Intellectual Property Organization, , ,

Production Method 19

92146-82-2

Reaction Conditions

Reference

Preparation of 1,5-benzodiazepine derivatives as cholecystokinin and/or gastrin antagonists

, World Intellectual Property Organization, , ,

tert-Butyl 3-aminobenzoate Raw materials

• Di-tert-butyl dicarbonate
• tert-Butyl 3-nitrobenzoate
• Benzoic acid, 3-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]-, 1,1-dimethylethyl ester
• Benzoic acid, 3-[[[2-(trimethylsilyl)ethyl]sulfonyl]amino]-, 1,1-dimethylethyl ester
• 3-Nitrobenzoic acid
• Benzoic acid, 3-chloro-, 1,1-dimethylethyl ester
• Tert-butyl 3-bromobenzoate

tert-Butyl 3-aminobenzoate Preparation Products

• tert-Butyl 3-aminobenzoate (92146-82-2)

• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 5. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151

• 18144-43-9(Isopropyl 4-aminobenzoate)
• 345205-42-7(Benzoic acid,3,5-diamino-, 1-methylethyl ester)
• 167993-12-6(5-Amino-di-t-butyl isophathalate)
• 18144-47-3(Tert-Butyl 4-aminobenzoate)
• 209223-88-1(Benzoic acid,5-amino-2-methyl-, 1,1-dimethylethyl ester)
• 35005-25-5(Isopropyl 3-aminobenzoate)
• 170030-61-2(Benzoic acid, 3,5-diamino-, 1,1-dimethylethyl ester (9CI))
• 445003-39-4(tert-butyl 4-amino-2-methylbenzoate)
• 62754-26-1(tert-butyl 3,4-diaminobenzoate)
• 934481-43-3(tert-Butyl 4-amino-3-methylbenzoate)