- Preparation of pyrrolopyridine-2-carboxamide derivatives as VR1 type capsaicin receptor antagonists, World Intellectual Property Organization, , ,
Cas no 920978-94-5 (5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid)
![5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid structure](https://ossimg.kuujia.com/scimg/921000/920978-94-5x500.png)
920978-94-5 structure
Product Name:5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
CAS No:920978-94-5
MF:C8H5FN2O2
MW:180.13590502739
MDL:MFCD11518911
CID:796858
PubChem ID:45480298
Update Time:2024-10-26
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Chemical and Physical Properties
Names and Identifiers
-
- 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
- 1H-Pyrrolo[2,3-b]pyridine-2-carboxylicacid, 5-fluoro-
- 5-Fluoro-7-azaindole-2-carboxylic acid
- 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID, 5-FLUORO-
- 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylicacid
- PubChem14919
- GLNFIUUKQXOTOZ-UHFFFAOYSA-N
- 5556AC
- ZB0307
- FCH894326
- PB16400
- EN000869
- AX8159157
- ST24044718
- 978F945
- A844144
- 1H-Pyr
- 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (ACI)
- AS-50802
- J-517494
- SY097839
- SCHEMBL297192
- CS-0004680
- AKOS006325785
- P11143
- DB-079230
- 1H-5-fluoro-pyrrolo[2,3-b]pyridine-2-carboxylic acid
- MFCD11518911
- DTXSID50670292
- 920978-94-5
-
- MDL： MFCD11518911
- Inchi： 1S/C8H5FN2O2/c9-5-1-4-2-6(8(12)13)11-7(4)10-3-5/h1-3H,(H,10,11)(H,12,13)
- InChI Key： GLNFIUUKQXOTOZ-UHFFFAOYSA-N
- SMILES： O=C(C1NC2C(=CC(=CN=2)F)C=1)O
Computed Properties
- Exact Mass: 180.03400
- Monoisotopic Mass: 180.034
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 13
- Rotatable Bond Count: 1
- Complexity: 224
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 66
- XLogP3: 1.3
Experimental Properties
- Density: 1.6±0.1 g/cm3
- Boiling Point: 448.9±40.0 °C at 760 mmHg
- Flash Point: 225.3±27.3 °C
- Refractive Index: 1.707
- PSA: 65.98000
- LogP: 1.40020
- Vapor Pressure: 0.0±1.1 mmHg at 25°C
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM148248-100mg |
5-Fluoro-7-azaindole-2-carboxylic acid |
920978-94-5 | 95%+ | 100mg |
$51 | 2021-08-05 | |
| Chemenu | CM148248-250mg |
5-Fluoro-7-azaindole-2-carboxylic acid |
920978-94-5 | 95%+ | 250mg |
$119 | 2021-08-05 | |
| Chemenu | CM148248-1g |
5-Fluoro-7-azaindole-2-carboxylic acid |
920978-94-5 | 95%+ | 1g |
$357 | 2021-08-05 | |
| abcr | AB458246-1 g |
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; . |
920978-94-5 | 1g |
€215.50 | 2023-07-18 | ||
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | F70280-250mg |
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid |
920978-94-5 | 95% | 250mg |
￥1488.0 | 2023-09-07 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | F70280-1g |
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid |
920978-94-5 | 95% | 1g |
￥2978.0 | 2023-09-07 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | F70280-100mg |
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid |
920978-94-5 | 95% | 100mg |
￥448.0 | 2023-09-07 | |
| TRC | F402588-10mg |
5-Fluoro-1H-pyrrolo[2,3-B]pyridine-2-carboxylic Acid |
920978-94-5 | 10mg |
$ 50.00 | 2022-06-05 | ||
| TRC | F402588-50mg |
5-Fluoro-1H-pyrrolo[2,3-B]pyridine-2-carboxylic Acid |
920978-94-5 | 50mg |
$ 160.00 | 2022-06-05 | ||
| TRC | F402588-100mg |
5-Fluoro-1H-pyrrolo[2,3-B]pyridine-2-carboxylic Acid |
920978-94-5 | 100mg |
$ 250.00 | 2022-06-05 |
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Dabco Solvents: Dimethylformamide ; > 1 min, rt
1.2 Catalysts: Palladium diacetate ; 20 min, rt; 3 h, rt → 100 °C; cooled
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3, 0 °C
1.2 Catalysts: Palladium diacetate ; 20 min, rt; 3 h, rt → 100 °C; cooled
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 3, 0 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Dabco Catalysts: Palladium diacetate Solvents: Dimethylformamide ; 2.5 h, rt → 100 °C; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt → 0 °C; pH 3
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt → 0 °C; pH 3
Reference
- Preparation of N-(aminoheteroaryl)-1H-pyrrolopyridine-2-carboxamides as VR1 type capsaicin receptor antagonists, World Intellectual Property Organization, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Dabco Solvents: Dimethylformamide ; rt
1.2 Catalysts: Palladium diacetate ; 2.5 h, rt → 100 °C; cooled
1.2 Catalysts: Palladium diacetate ; 2.5 h, rt → 100 °C; cooled
Reference
- Preparation of tricyclic N-(heteroaryl)-carboxamide derivatives as VR1 type capsaicin receptor ligands, World Intellectual Property Organization, , ,
Production Method 4
Reaction Conditions
Reference
- Preparation of 1-(arylalkyl)-1H-pyrrolopyridine-2-carboxamide derivatives as VR1 type capsaicin receptor antagonists, World Intellectual Property Organization, , ,
Production Method 5
Reaction Conditions
Reference
- Preparation of pyrrolopyridine-2-carboxamide derivatives as VR1 type capsaicin receptor antagonists, France, , ,
Production Method 6
Reaction Conditions
Reference
- Preparation of N-(aminoheteroaryl)-1H-pyrrolopyridine-2-carboxamides as VR1 type capsaicin receptor antagonists, France, , ,
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Raw materials
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Preparation Products
5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid Related Literature
-
Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
-
Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
-
Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
920978-94-5 (5-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid) Related Products
- 136818-50-3(1H-Pyrrolo[2,3-b]pyridine-2-carboxylic Acid)
- 215523-34-5(1,8-Naphthyridine-2-carboxylic acid)
- 1016241-78-3(3-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid)
- 107504-08-5(5-Fluoropyridine-2-carboxylic Acid)
- 913181-73-4(1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid hydrochloride)
- 898746-35-5(1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid)
- 1246088-56-1(5-Fluoro-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid)
- 920978-95-6(Ethyl 5-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylate)
- 1016241-77-2(2-Butenamide, N-[2,5-bis(trifluoromethyl)phenyl]-2-cyano-3-hydroxy-, (2Z)-)
- 1204476-04-9(1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 3-fluoro-4-hydroxy-)
Recommended suppliers
Shenzhen Yaoyuan R&D Center Co.,Ltd
Gold Member
Audited Supplier
CN Supplier
Bulk
Wuhan ChemNorm Biotech Co.,Ltd.
Gold Member
Audited Supplier
CN Supplier
Reagent
Hubei Cuiyuan Biotechnology Co.,Ltd
Gold Member
Audited Supplier
CN Supplier
Reagent
Wuhan Comings Biotechnology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
Jinta Yudi Pharmaceutical Technology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
