- Synthesis of naphthol AS-X chloroacetates and study on the electron effects on the human leukocyte esterase stainingTran, Van Tinh; Pham, Hoai Thu; Nguyen, Anh Tri; Luu, Van Boi, Tap Chi Hoa Hoc, 2011, 49(4), 479-488
Cas no 92-78-4 (Naphthol AS-E)
Naphthol AS-E structure
Product Name:Naphthol AS-E
CAS No:92-78-4
MF:C17H12ClNO2
MW:297.735683441162
MDL:MFCD00021639
CID:34665
PubChem ID:87559054
Update Time:2024-10-26
Naphthol AS-E Chemical and Physical Properties
Names and Identifiers
-
- Naphthol AS-E
- C.I.Azoic Coupling Component 10
- 4'-Chloro-3-hydroxy-2-naphthanilide
- 1-(4-Pyridyl)Ethylamine
- N-(4-chlorophenyl)-3-hydroxynaphthalene-2-carboxamide
- 3-Hydroxy-[2]naphthoesaeure-(4-chlor-anilid)
- 3-hydroxy-[2]naphthoic acid-(4-chloro-anilide)
- 3-hydroxy-naphthalene-2-carboxylic acid 4-chloro-anilide
- Amanil Naphthol AS-E
- Cibanaphthol RC
- Daito Grounder E
- Naphtanilide E
- Naphtazol E
- Naphtoelan E
- Sanatol E
- Azoic Coupling Component 10
- N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide
- C.I. 37510
- C.I. Azoic Coupling Component 10
- 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-hydroxy-
- Tulathol AS-E
- Amarthol AS-E
- Acna Naphthol PC
- Naphthol ACNA PC
- Hiltonaphthol AS-E
- Naphtol AS-E Supra
- C.I. 375
- 2-Naphthanilide, 4′-chloro-3-hydroxy- (6CI, 7CI, 8CI)
- N-(4-Chlorophenyl)-3-hydroxy-2-naphthalenecarboxamide (ACI)
- 3-Hydroxy-4′-chloro-2-naphthanilide
- 4′-Chloro-3-hydroxy-2-naphthanilide
- Anarthol AS-E
- Conazoic AO
- Dycosthol AS-E
- Kako Grounder E
- Kiwa Grounder E
- Naftol AS-E
- Napthol ASE
- NSC 50684
- Red RC Base
- BDBM50091999
- NS00010053
- N-(4-Chlorophenyl)(3-hydroxy(2-naphthyl))carboxamide
- 2-Naphthanilide, 4'-chloro-3-hydroxy-
- EC 202-189-7
- DTXSID7059066
- CB05876
- NSC751298
- SR-01000200943
- SMSF0005400
- Q27271063
- 3-Hydroxy-naphthalene-2-carboxylic acid (4-chloro-phenyl)-amide
- SCHEMBL2743095
- N-(4-chlorophenyl)-3-hydroxy-naphthalene-2-carboxamide
- 4'-CHLORO-3-HYDROXY-2-NAPTHANILIDE
- CS-0028070
- nAS-E
- CHEMBL65653
- CBMicro_013654
- MFCD00021639
- SR-01000200943-1
- N-(4-chlorophenyl)-3-hydroxy-2-naphthalenecarboxamide
- 92-78-4
- W-100272
- HY-104068
- NSC-751298
- CI 37510
- Oprea1_676950
- DB-057331
- C2103
- UNII-8V561WAE43
- BIM-0013553.P001
- 8V561WAE43
- GLXC-20245
- 3-HYDROXY-4'-CHLORO-2-NAPHTHANILIDE
- OHAXNCGNVGGWSO-UHFFFAOYSA-
- NSC50684
- AKOS008973402
- A10918
- EINECS 202-189-7
- NSC-50684
- InChI=1/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)
-
- MDL： MFCD00021639
- Inchi： 1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)
- InChI Key： OHAXNCGNVGGWSO-UHFFFAOYSA-N
- SMILES： O=C(C1C(O)=CC2C(=CC=CC=2)C=1)NC1C=CC(Cl)=CC=1
Computed Properties
- Exact Mass: 297.05600
- Monoisotopic Mass: 297.056
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 21
- Rotatable Bond Count: 2
- Complexity: 368
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 49.3
- Surface Charge: 0
- Tautomer Count: 9
- XLogP3: 4.8
Experimental Properties
- Color/Form: Light beige powder
- Density: 1.399
- Melting Point: 264°C(lit.)
- Boiling Point: 416.5 °C at 760 mmHg
- Flash Point: 205.7 °C
- Refractive Index: 1.735
- PSA: 49.33000
- LogP: 4.52410
- Color index: 37510
- Solubility: Soluble in o-dichlorobenzene, insoluble in water and sodium carbonate solution. Yellow in sodium hydroxide solution
Naphthol AS-E Security Information
- WGK Germany：3
- Safety Instruction： S7; S36; S24/25
- RTECS：MR0176000
-
Hazardous Material Identification：
- Risk Phrases：R42/43
Naphthol AS-E Customs Data
- HS CODE：29053980
- Customs Data：
China Customs Code:
2924299090Overview:
2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, packing
Summary:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Naphthol AS-E Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-104068-10mM*1mLinDMSO |
Naphthol AS-E |
92-78-4 | ≥98.0% | 10mM*1mLinDMSO |
￥660 | 2023-07-26 | |
| MedChemExpress | HY-104068-100mg |
Naphthol AS-E |
92-78-4 | ≥98.0% | 100mg |
￥600 | 2024-07-20 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | C2103-25g |
Naphthol AS-E |
92-78-4 | 97.0%(N) | 25g |
￥470.0 | 2022-05-30 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | C869431-5g |
4'-Chloro-3-hydroxy-2-naphthanilide |
92-78-4 | 97% | 5g |
140.40 | 2021-05-17 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T7856-5 mg |
nAS-E |
92-78-4 | 99.85% | 5mg |
￥258.00 | 2022-02-28 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | N83610-500g |
N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide |
92-78-4 | 97% | 500g |
￥310.0 | 2024-07-19 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | N83610-100g |
N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide |
92-78-4 | 97% | 100g |
￥123.0 | 2024-07-19 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | N83610-25g |
N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide |
92-78-4 | 97% | 25g |
￥43.0 | 2024-07-19 | |
| TRC | C587828-2.5g |
4'-Chloro-3-hydroxy-2-naphthanilide |
92-78-4 | 2.5g |
$ 50.00 | 2022-06-06 | ||
| TRC | C587828-5g |
4'-Chloro-3-hydroxy-2-naphthanilide |
92-78-4 | 5g |
$ 65.00 | 2022-06-06 |
Naphthol AS-E Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Phosphorus trichloride Solvents: Chlorobenzene ; rt → 10 °C; 10 °C; 15 min, 135 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride Solvents: Chlorobenzene ; rt; rt → 130 °C; 25 min, 130 °C
Reference
- Preparation and biological properties of ring-substituted 3-hydroxynaphthalene-2-carboxanilidesKos, Jiri; Zadrazilova, Iveta; Pesko, Matus; Pavlica, Jiri; Gonec, Tomas; et al, International Electronic Conference on Synthetic Organic Chemistry, 2012, ,
Production Method 3
Reaction Conditions
Reference
- Production method and apparatus of naphthol AS series products, China, , ,
Production Method 4
Reaction Conditions
Reference
- Design, synthesis, and biological evaluation of conformationally constrained analogues of naphthol AS-E as inhibitors of CREB-mediated gene transcriptionJiang, Min; Li, Bingbing X.; Xie, Fuchun; Delaney, Frances; Xiao, Xiangshu, Journal of Medicinal Chemistry, 2012, 55(8), 4020-4024
Production Method 5
Reaction Conditions
Reference
- Benzamide, naphthalenecarboxamide, arylacetamide, arenesulfonamide, carbamate, thiocarbamate, and benzylamine inhibitors of inosine-5'-monophosphate dehydrogenase, World Intellectual Property Organization, , ,
Production Method 6
Reaction Conditions
1.1 Reagents: Phosphorus trichloride Solvents: Chlorobenzene ; rt; 10 min, 100 °C; 15 min, 120 °C; 20 min, 130 °C
Reference
- Antibacterial and herbicidal activity of ring-substituted 3-hydroxynaphthalene-2-carboxanilidesKos, Jiri; Zadrazilova, Iveta; Pesko, Matus; Keltosova, Stanislava; Tengler, Jan; et al, Molecules, 2013, 18, 7977-7997
Production Method 7
Reaction Conditions
1.1 Reagents: Phosphorus trichloride Solvents: Chlorobenzene ; 10 min, 100 °C; 15 min, 120 °C; 20 min, 130 °C
Reference
- 3-Hydroxynaphthalene-2-carboxanilides and their antitrypanosomal activityKos, Jiri; Kapustikova, Iva; Clements, Carol; Gray, Alexander I.; Jampilek, Josef, Monatshefte fuer Chemie, 2018, 149(5), 887-892
Production Method 8
Reaction Conditions
1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide , Chlorobenzene ; 1.5 h, 35 - 40 °C
1.2 Reagents: Sodium acetate Solvents: Dimethylformamide ; 0.5 h, 5 - 10 °C; 3 h, 20 °C; 20 °C → 50 °C
1.2 Reagents: Sodium acetate Solvents: Dimethylformamide ; 0.5 h, 5 - 10 °C; 3 h, 20 °C; 20 °C → 50 °C
Reference
- Synthesis and β-adrenergic blocking activity of naphthyloxypropylaminesVattipalli, Ramya; Shirodkar, Prabhakar Y.; Somani, Rakesh R.; Kadam, Vilasrao J., Indian Journal of Chemistry, 2008, (10), 1587-1590
Production Method 9
Production Method 10
Reaction Conditions
Reference
- N-Substituted amides of 3-hydroxy-2-naphthalenecarboxylic acid, Poland, , ,
Naphthol AS-E Raw materials
Naphthol AS-E Preparation Products
Naphthol AS-E Related Literature
-
Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
-
Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
-
Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
-
Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
Related Categories
- Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalenecarboxamides
- Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalenecarboxylic acids and derivatives Naphthalenecarboxamides
- Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
92-78-4 (Naphthol AS-E) Related Products
- 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
- 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
- 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
- 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
- 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
- 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
- 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
- 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
- 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
- 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)
Recommended suppliers
Nanjing jingzhu bio-technology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
Hubei Cuiyuan Biotechnology Co.,Ltd
Gold Member
Audited Supplier
CN Supplier
Reagent
Shandong Feiyang Chemical Co., Ltd
Gold Member
Audited Supplier
CN Supplier
Bulk
Zhejiang Brunova Technology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
SunaTech Inc.
Gold Member
Audited Supplier
CN Supplier
Reagent
