Production Method 1

203662-40-2

919360-49-9

Reaction Conditions

1.1 Reagents: Calcium chloride ,  Sodium borohydride Solvents: Ethanol ;  cooled; 24 h, rt

Reference

Fused heterocyclic compounds as GPR119 agonists for treatment of diabetes and obesity

, World Intellectual Property Organization, , ,

Production Method 2

203662-40-2

919360-49-9

Reaction Conditions

1.1 Reagents: Calcium chloride ,  Sodium borohydride Solvents: Ethanol ;  0 °C; 24 h, rt

Reference

Preparation of substituted quinazolinones for the degradation of mutant BRAF

, World Intellectual Property Organization, , ,

Production Method 3

203662-40-2

919360-49-9

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 1 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Preparation of piperidinecarboxylates as G protein-coupled receptor (GPR119) agonists.

, World Intellectual Property Organization, , ,

4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester Raw materials

• Tert-butyl 4-(4-ethoxy-4-oxobutan-2-yl)piperidine-1-carboxylate

4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester Preparation Products

• 4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (919360-49-9)

• 1. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 5. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Introduction to 4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS No. 919360-49-9) in Modern Chemical and Pharmaceutical Research

4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester, identified by the CAS number 919360-49-9, is a compound of significant interest in the field of chemical and pharmaceutical research. This molecule, featuring a piperidine core and a hydroxymethyl side chain, has garnered attention due to its structural versatility and potential applications in drug discovery and molecular biology. The piperidine ring is a common pharmacophore in medicinal chemistry, known for its ability to enhance binding affinity and metabolic stability in bioactive molecules. The presence of the 3-hydroxy-1-methylpropyl substituent introduces hydrophilic and lipophilic properties, making it a promising candidate for modulating biological pathways.

The 1,1-dimethylethyl ester moiety further contributes to the compound's chemical profile by providing a site for further functionalization or by influencing its solubility and reactivity. This structural feature is particularly valuable in synthetic chemistry, where it can serve as an intermediate in the development of more complex molecules. The combination of these functional groups suggests that this compound may exhibit a range of biological activities, depending on its interactions with target proteins or enzymes.

In recent years, there has been growing interest in piperidine derivatives as scaffolds for therapeutic agents. For instance, studies have demonstrated that piperidine-based compounds can modulate neurotransmitter receptors, kinases, and other critical targets involved in diseases such as cancer, inflammation, and neurological disorders. The 4-(3-hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS No. 919360-49-9) may serve as a valuable building block for designing novel therapeutics that leverage these properties.

One of the most compelling aspects of this compound is its potential role in drug development. The hydroxymethyl group (-OH) can participate in hydrogen bonding interactions, which are crucial for binding to biological targets. Additionally, the ester group can be hydrolyzed under specific conditions to yield a free carboxylic acid, offering flexibility in chemical modifications. These features make it an attractive candidate for exploring new pharmacological pathways.

Recent research has highlighted the importance of structural diversity in drug discovery programs. Compounds like 4-(3-hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS No. 919360-49-9) contribute to this diversity by providing unique structural motifs that may not be present in existing libraries of compounds. This is particularly relevant in the context of addressing drug resistance or developing treatments for rare diseases, where novel chemical entities are often required.

The synthesis of this compound involves multi-step organic reactions that require careful optimization to ensure high yield and purity. Advanced synthetic techniques such as catalytic hydrogenation, nucleophilic substitution, and esterification play key roles in constructing the desired structure. The availability of high-quality starting materials and well-established synthetic protocols are essential for producing this compound on a scalable basis.

In addition to its synthetic significance, 4-(3-hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS No. 919360-49-9) may find applications in biochemical assays as a substrate or inhibitor for enzymes with piperidine-binding pockets. Such studies can provide insights into enzyme mechanisms and aid in the development of enzyme inhibitors with therapeutic potential.

The compound's physicochemical properties, including solubility and stability under various conditions, are critical factors that influence its utility in research and development. For example, solubility data can guide decisions regarding formulation strategies if the compound is to be used as an active pharmaceutical ingredient (API). Stability studies help ensure that the compound remains viable during storage and transportation.

As computational chemistry advances, virtual screening methods are increasingly being used to identify promising candidates like 4-(3-hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS No. 919360-49-9) based on their predicted binding affinities to biological targets. These approaches can significantly reduce the time and cost associated with hit identification and lead optimization processes.

The role of this compound in interdisciplinary research is also noteworthy. Its structural features make it relevant not only to medicinal chemistry but also to materials science and agrochemicals. For instance, derivatives of piperidine have been explored as components in liquid crystals or as intermediates for crop protection agents.

In conclusion,4-(3-Hydroxy-1-methylpropyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester (CAS No. 919360-49-9) represents a fascinating chemical entity with broad potential applications across multiple domains of science and industry. Its unique structural attributes position it as a valuable tool for researchers seeking to develop novel therapeutics or explore new biochemical pathways.

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