Production Method 1

56-81-5

454-79-5

917251-92-4

Reaction Conditions

1.1 Catalysts: Sodium iodide ;  110 °C → 150 °C
1.2 Reagents: Sulfuric acid ;  150 °C; 1 h, 150 °C; 150 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized, rt

Reference

Auxiliary-Directed C(sp3)-H Arylation by Synergistic Photoredox and Palladium Catalysis

Czyz, Milena L. ; et al, Chemistry - A European Journal, 2017, 23(58), 14450-14453

Production Method 2

56-81-5

454-79-5

917251-92-4

Reaction Conditions

1.1 Reagents: Methanesulfonic acid ,  Benzenesulfonic acid, 3-nitro-, sodium salt (1:1) Catalysts: Ferrous sulfate ;  20 h, 125 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  basified

Reference

Induction of Axial Chirality in 8-Arylquinolines through Halogenation Reactions Using Bifunctional Organocatalysts

Miyaji, Ryota; et al, Chemistry - A European Journal, 2017, 23(42), 9996-10000

8-Bromo-5-(trifluoromethyl)quinoline Raw materials

• Glycerol
• 3-Amino-4-bromobenzotrifluoride

8-Bromo-5-(trifluoromethyl)quinoline Preparation Products

• 8-Bromo-5-(trifluoromethyl)quinoline (917251-92-4)

• 1. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines

8-Bromo-5-(trifluoromethyl)quinoline: A Comprehensive Overview

8-Bromo-5-(trifluoromethyl)quinoline is a highly specialized organic compound with the CAS number 917251-92-4. This compound belongs to the quinoline family, which is a heterocyclic aromatic system with a nitrogen atom at position 1. The presence of a bromine atom at position 8 and a trifluoromethyl group at position 5 introduces unique electronic and structural properties, making it a valuable molecule in various fields of research and application.

The synthesis of 8-Bromo-5-(trifluoromethyl)quinoline involves advanced organic chemistry techniques, often requiring precise control over reaction conditions to achieve high yields and purity. Recent studies have focused on optimizing the synthesis pathways, leveraging catalytic methods and microwave-assisted reactions to enhance efficiency. These advancements have not only improved the scalability of production but also reduced environmental impact, aligning with current sustainability goals in chemical manufacturing.

One of the most promising applications of 8-Bromo-5-(trifluoromethyl)quinoline lies in the field of drug discovery. The compound has demonstrated significant potential as a lead molecule in the development of novel therapeutics targeting various diseases, including cancer and neurodegenerative disorders. Researchers have explored its ability to modulate key cellular pathways, such as kinase signaling and oxidative stress responses, which are critical in disease progression.

In addition to its therapeutic applications, 8-Bromo-5-(trifluoromethyl)quinoline has shown remarkable properties in materials science. Its unique electronic structure makes it an ideal candidate for use in organic electronics, particularly in the development of light-emitting diodes (LEDs) and photovoltaic devices. Recent studies have highlighted its ability to act as an efficient electron transporter, significantly improving device performance and stability.

The compound's stability under various environmental conditions has also made it a valuable tool in analytical chemistry. It is frequently used as a reference standard in spectroscopic analyses due to its well-defined spectral characteristics. Furthermore, its resistance to photodegradation makes it suitable for long-term storage and use in demanding experimental setups.

Recent advancements in computational chemistry have provided deeper insights into the molecular behavior of 8-Bromo-5-(trifluoromethyl)quinoline. Quantum mechanical simulations have revealed its electronic distribution patterns, which are crucial for understanding its reactivity and interaction with biological systems. These findings have paved the way for more targeted modifications of the molecule to enhance its desired properties.

In conclusion, 8-Bromo-5-(trifluoromethyl)quinoline is a versatile compound with a wide range of applications across multiple disciplines. Its unique chemical structure, combined with recent research breakthroughs, positions it as a key player in advancing scientific innovation. As ongoing studies continue to uncover new potential uses, this compound is poised to make significant contributions to both academic research and industrial applications.

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