Production Method 1

16567-18-3

917251-86-6

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Solvents: Acetic acid ;  rt; overnight, 70 °C
2.1 Reagents: Cuprous iodide ,  Potassium fluoride ;  heated; cooled
2.2 Reagents: N-Methyl-2-pyrrolidone Solvents: N-Methyl-2-pyrrolidone ;  overnight, 50 °C; 50 °C → rt
2.3 Reagents: Ammonium hydroxide Solvents: Water ;  rt

Reference

The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT1A Antagonists

Childers, Wayne E. Jr.; et al, Journal of Medicinal Chemistry, 2010, 53(10), 4066-4084

Production Method 2

81290-20-2

917251-85-5

917251-86-6

Reaction Conditions

1.1 Reagents: Cuprous iodide ,  Potassium fluoride ;  heated; cooled
1.2 Reagents: N-Methyl-2-pyrrolidone Solvents: N-Methyl-2-pyrrolidone ;  overnight, 50 °C; 50 °C → rt
1.3 Reagents: Ammonium hydroxide Solvents: Water ;  rt

Reference

The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT1A Antagonists

Childers, Wayne E. Jr.; et al, Journal of Medicinal Chemistry, 2010, 53(10), 4066-4084

8-Bromo-3-(trifluoromethyl)quinoline Raw materials

• 8-Bromoquinoline
• trimethyl(trifluoromethyl)silane
• 8-bromo-3-iodo-quinoline

8-Bromo-3-(trifluoromethyl)quinoline Preparation Products

• 8-Bromo-3-(trifluoromethyl)quinoline (917251-86-6)

• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• 3. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
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• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• 663193-19-9(Quinoline, 8-bromo-4-(trifluoromethyl)-)
• 1065074-30-7(6-Bromo-8-trifluoromethylquinoline)
• 917251-92-4(8-Bromo-5-(trifluoromethyl)quinoline)
• 1239460-75-3(5-bromo-8-(trifluoromethyl)quinoline)
• 1447953-13-0(3-bromo-6-(trifluoromethyl)quinoline)
• 436799-33-6(3-Bromo-5-(trifluoromethyl)pyridine)
• 1260658-60-3(5-bromo-7-(trifluoromethyl)-1H-indole)
• 260973-10-2(4-Bromo-8-trifluoromethylquinoline)
• 1059064-11-7(3-bromo-8-(trifluoromethyl)quinoline)
• 875306-23-3(7-bromo-5-(trifluoromethyl)-1H-indole)