Production Method 1

78775-11-8

916792-23-9

Reaction Conditions

1.1 Reagents: Pyridinium, 1-fluoro-2,4,6-trimethyl-, 1,1,1-trifluoromethanesulfonate (1:1) Catalysts: Aniline-2,4-disulfonic acid ,  Palladium diacetate Solvents: 1,2-Dichloroethane ;  10 h, rt; 24 h, 110 °C

Reference

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

Chen, Xiao-Yang ; et al, Journal of the American Chemical Society, 2018, 140(8), 2789-2792

Production Method 2

134332-29-9

916792-23-9

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  10 min, -78 °C; 30 min, -78 °C
1.2 Solvents: Tetrahydrofuran ;  5 min, -78 °C; -78 °C → rt; 2 h, rt
1.3 Reagents: Sodium chloride ;  rt

Reference

Rational Design of a Red Fluorescent Sensor for ALDH1A1 Displaying Enhanced Cellular Uptake and Reactivity

Bearrood, Thomas E. ; et al, Bioconjugate Chemistry, 2020, 31(2), 224-228

4-bromo-2-fluoro-5-methyl-benzaldehyde Raw materials

• 1,4-Dibromo-2-fluoro-5-methylbenzene
• 4-Bromo-3-methylbenzaldehyde

4-bromo-2-fluoro-5-methyl-benzaldehyde Preparation Products

• 4-bromo-2-fluoro-5-methyl-benzaldehyde (916792-23-9)

• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

• 57848-46-1(4-bromo-2-fluoro-benzaldehyde)
• 93777-26-5(2-Fluoro-5-bromobenzaldehyde)
• 537013-51-7(4-Bromo-2,6-difluorobenzaldehyde)
• 360576-04-1(6-Bromo-2,3-difluorobenzaldehyde)
• 916792-21-7(2-Bromo-5-fluoro-4-methylbenzaldehyde)
• 154650-59-6(2-Bromo-4,6-difluorobenzaldehyde)
• 59142-68-6(2-Bromo-4-fluorobenzaldehyde)
• 154650-16-5(2-Bromo-6-fluoro-3-methylbenzaldehyde)
• 916792-17-1(2-Bromo-4-fluoro-5-methylbenzaldehyde)
• 360575-28-6(2-Bromo-6-fluorobenzaldehyde)