Production Method 1

2926-29-6

100-48-1

916210-02-1

1214383-56-8

Reaction Conditions

1.1 Reagents: Poly(oxy-1,2-ethanediyl), α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trime… Solvents: Water ;  rt → 5 °C; 2 - 3 min, 5 °C
1.2 Reagents: tert-Butyl hydroperoxide Solvents: Water ;  5 °C; 44 h, 23 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  23 °C

Reference

Trifluoromethylation of heterocycles in water at room temperature

Fennewald, James C.; Lipshutz, Bruce H., Green Chemistry, 2014, 16(3), 1097-1100

Production Method 2

2926-29-6

100-48-1

916210-02-1

1346251-98-6

1214383-56-8

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide Solvents: Dichloromethane ,  Water ;  0 °C; 0 °C → 23 °C; 40 h, 23 °C

Reference

Innate C-H trifluoromethylation of heterocycles

Ji, Yining; Brueckl, Tobias; Baxter, Ryan D.; Fujiwara, Yuta; Seiple, Ian B.; et al, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(35), 14411-14415

Production Method 3

100-48-1

39971-65-8

916210-02-1

1214383-56-8

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Pyridine Solvents: Dimethyl sulfoxide ;  1.5 - 2 h, 50 °C

Reference

Radical-Based Regioselective C-H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability

O'Hara, Fionn; Blackmond, Donna G.; Baran, Phil S., Journal of the American Chemical Society, 2013, 135(32), 12122-12134

2-(Trifluoromethyl)isonicotinonitrile Raw materials

• Sodium Triflinate
• 4-Cyanopyridine
• Zinc(II) Bis(trifluoromethanesulfinate) Dihydrate

2-(Trifluoromethyl)isonicotinonitrile Preparation Products

• 2-(3,3,3-Trifluoro-1,1-dimethylpropyl)-4-pyridinecarbonitrile (1346251-98-6)
• 3-(Trifluoromethyl)isonicotinonitrile (1214383-56-8)
• 2-(Trifluoromethyl)isonicotinonitrile (916210-02-1)

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