• 1. 4-Cyanopyridine, a versatile mono- and bidentate ligand. Crystal structures of related coordination polymers determined by X-ray powder diffraction
  Haishuang Zhao,Alexander Bodach,Miriam Heine,Yasar Krysiak,Jürgen Glinnemann,Edith Alig,Lothar Fink,Martin U. Schmidt CrystEngComm 2017 19 2216
• 2. Chemistry of 6H-pyrido[3,4-b]carbazoles. Part 6. The structure of some dihydropyridines derived from the addition of cyanide ion to 1-(N-methylacetamido)pyridinium salts and their further reactions
  Michael Driver,Malcolm Sainsbury J. Chem. Soc. Perkin Trans. 1 1979 2502
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives
• Pharmaceutical and Biochemical Products Medicinal Building Blocks Heterocyclic Building Blocks
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds

Introduction to 4-Cyanopyridine (CAS No. 100-48-1)

4-Cyanopyridine, with the chemical formula C?H?N?, is a heterocyclic organic compound belonging to the pyridine family. This compound is characterized by a pyridine ring substituted with a cyano group at the 4-position. Its CAS number, 100-48-1, uniquely identifies it in chemical databases and literature, making it a key reference for researchers and industrial applications. The structural features of 4-Cyanopyridine contribute to its versatility, enabling its use in various synthetic pathways and as an intermediate in pharmaceutical and agrochemical industries.

The cyano group in 4-Cyanopyridine is a highly reactive functional moiety, which allows for further chemical modifications such as reduction to an amine or substitution reactions. This reactivity has made 4-Cyanopyridine a valuable building block in medicinal chemistry. Recent studies have highlighted its role in the synthesis of bioactive molecules, particularly in the development of small-molecule inhibitors targeting neurological and inflammatory disorders.

In the pharmaceutical industry, 4-Cyanopyridine has been utilized in the synthesis of antiviral and anticancer agents. For instance, derivatives of 4-Cyanopyridine have shown promise in inhibiting enzymes involved in cancer cell proliferation. The compound’s ability to act as a scaffold for drug design has been leveraged to develop novel therapeutics with improved pharmacokinetic properties. Furthermore, its incorporation into drug molecules has been associated with enhanced binding affinity to biological targets, thereby increasing the efficacy of the final pharmaceutical products.

Recent advancements in computational chemistry have further elucidated the potential of 4-Cyanopyridine as a key intermediate. Molecular modeling studies have demonstrated that modifications at the cyano-substituted position can fine-tune the electronic properties of the compound, influencing its interaction with biological receptors. This insight has guided the design of more potent and selective drug candidates.

Agrochemical applications of 4-Cyanopyridine have also gained attention due to its role in synthesizing herbicides and pesticides. The structural motifs present in 4-Cyanopyridine contribute to its bioactivity against various pests, making it a valuable component in crop protection formulations. Researchers have been exploring ways to optimize its efficacy while minimizing environmental impact, aligning with global sustainability goals.

The synthesis of 4-Cyanopyridine typically involves cyanation reactions on pyridine derivatives or functional group interconversions starting from readily available precursors. Advances in green chemistry have led to more sustainable synthetic routes, including catalytic methods that reduce waste and energy consumption. These innovations not only improve the economic feasibility of producing 4-Cyanopyridine but also enhance its overall environmental footprint.

Industrial-scale production of 4-Cyanopyridine requires careful optimization to ensure high yields and purity. Process chemists have employed continuous flow reactors and novel catalysts to enhance reaction efficiency. Such technologies have enabled manufacturers to meet growing demand while adhering to stringent quality standards.

The safety profile of 4-Cyanopyridine is another critical aspect that has been extensively studied. While it is not classified as a hazardous material under standard regulations, proper handling protocols must be followed to prevent exposure risks. Industrial facilities producing or utilizing 4-Cyanopyridine implement rigorous safety measures, including ventilation systems and personal protective equipment (PPE), to safeguard workers.

Future research directions for 4-Cyanopyridine are likely to focus on expanding its applications in drug discovery and material science. The development of new synthetic methodologies will continue to drive innovation, enabling access to novel derivatives with tailored properties. Collaborative efforts between academia and industry are expected to accelerate these developments, fostering advancements that benefit multiple sectors.

In conclusion, 4-Cyanopyridine (CAS No. 100-48-1) is a versatile compound with significant potential across pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structural features and reactivity make it indispensable in synthetic chemistry, while ongoing research continues to uncover new applications and improve production methods. As scientific understanding evolves, the role of 4-Cyanopyridine is poised to expand further, reinforcing its importance in modern chemical research.

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• 106778-42-1(6-Cyanoisoquinoline)
• 69046-49-7(Pyridine, 4-(methyl-d)-(9CI))
• 70704-65-3(Pyridinium, 4-cyano-, dicyanomethylide)
• 29372-29-0(4-Picoline-d7)
• 27655-41-0(isoquinoline-5-carbonitrile)
• 7584-05-6(4-Cyano-3-methylpyridine)
• 100-54-9(pyridine-3-carbonitrile)