Cas no 915405-01-5 (D-Serine, N-methyl-)

D-Serine, N-methyl- structure
D-Serine, N-methyl- structure
Product Name:D-Serine, N-methyl-
CAS No:915405-01-5
MF:C4H9NO3
MW:119.119161367416
CID:787089
PubChem ID:5288119
Update Time:2024-10-26

D-Serine, N-methyl- Chemical and Physical Properties

Names and Identifiers

    • D-Serine, N-methyl-
    • (2R)-3-hydroxy-2-(methylamino)propanoic acid
    • N-METHYL-D-SERINE HYDROCHLORIDE
    • N-Methyl-D-serine (ACI)
    • (R)-3-Hydroxy-2-(methylamino)propanoicacid
    • Q27459725
    • F11106
    • SCHEMBL170982
    • CS-0151242
    • BS-50942
    • (R)-3-Hydroxy-2-(methylamino)propanoic acid
    • N-METHYL-D-SERINE
    • MFCD19220663
    • 915405-01-5
    • DTXSID80415335
    • Inchi: 1S/C4H9NO3/c1-5-3(2-6)4(7)8/h3,5-6H,2H2,1H3,(H,7,8)/t3-/m1/s1
    • InChI Key: PSFABYLDRXJYID-GSVOUGTGSA-N
    • SMILES: [C@@H](NC)(CO)C(=O)O

Computed Properties

  • Exact Mass: 119.058243149g/mol
  • Monoisotopic Mass: 119.058243149g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 8
  • Rotatable Bond Count: 3
  • Complexity: 83.4
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -2.9
  • Topological Polar Surface Area: 69.6?2

Experimental Properties

  • Density: 1.242

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D-Serine, N-methyl- Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane ;  10 min, 25 °C
1.2 Reagents: (1R,2S,5R)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexanol ;  25 °C; 24 h, 25 °C
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane
1.4 Reagents: Triethylamine ;  1 h, 110 °C
1.5 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
1.6 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

Production Method 2

Reaction Conditions
1.1 Reagents: Triethylamine ;  1 h, 110 °C
2.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
2.2 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

Production Method 3

Reaction Conditions
1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane ;  10 min, 25 °C
1.2 25 °C; 24 h, 25 °C
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane
2.1 Reagents: Triethylamine ;  1 h, 110 °C
3.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
3.2 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

Production Method 4

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
1.2 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

Production Method 5

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
1.2 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

Production Method 6

Reaction Conditions
1.1 Reagents: Triethylamine ;  1 h, 110 °C
2.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
2.2 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

Production Method 7

Reaction Conditions
1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Dichloromethane ;  10 min, 25 °C; 25 °C; 24 h, 25 °C
1.2 25 °C; 24 h, 25 °C
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane
2.1 Reagents: Triethylamine ;  1 h, 110 °C
3.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  24 h, 78 °C
3.2 Reagents: (±)-Propylene oxide Solvents: Ethanol ;  30 min, 78 °C
Reference
Domino 1,3-dipolar cycloadditions of N-alkyl-α-amino esters with paraformaldehyde: a direct access to α-hydroxymethyl α-amino acids
Castello, Luis M.; et al, Synthesis, 2014, 46(7), 967-971

D-Serine, N-methyl- Raw materials

D-Serine, N-methyl- Preparation Products

D-Serine, N-methyl- Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:915405-01-5)D-Serine, N-methyl-
Order Number:A900795
Stock Status:in Stock
Quantity:1g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 12:06
Price ($):228.0/797.0
Recommended suppliers
Amadis Chemical Company Limited
(CAS:915405-01-5)D-Serine, N-methyl-
A900795
Purity:99%/99%
Quantity:1g/5g
Price ($):228.0/797.0
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