Cas no 3913-67-5 (H-N-Me-Ala-OH)

H-N-Me-Ala-OH, also known as N-Methyl-L-alanine, is a non-proteinogenic amino acid derivative characterized by the methylation of the amide nitrogen in the alanine backbone. This modification enhances its steric and electronic properties, making it valuable in peptide synthesis and medicinal chemistry. The methyl group introduces conformational constraints, improving peptide stability and resistance to enzymatic degradation. It is commonly employed in the design of peptidomimetics and bioactive compounds. The compound is typically supplied as a white crystalline powder with high purity, ensuring consistent performance in research and industrial applications. Its compatibility with standard peptide coupling reagents further facilitates its use in solid-phase and solution-phase synthesis.
H-N-Me-Ala-OH structure
H-N-Me-Ala-OH structure
Product Name:H-N-Me-Ala-OH
CAS No:3913-67-5
MF:C4H9NO2
MW:103.119761228561
MDL:MFCD00037241
CID:44580
PubChem ID:24845362
Update Time:2025-05-20

H-N-Me-Ala-OH Chemical and Physical Properties

Names and Identifiers

    • (S)-2-(Methylamino)propanoic acid
    • N-Methyl-L-aminopropanoic acid
    • (2S)-2-(methylamino)propanoic acid
    • H-L-MeAla-OH*HCl
    • H-N-Me-Ala-OH.HCl
    • N-Me-Ala-OH
    • N-METHYL-L-ALANINE
    • N-α-Methyl-L-alanine
    • H-MeAla-OH
    • N-Methylalanine
    • L-Alanine, N-methyl-
    • Alanine, N-methyl-
    • H-N-Me-Ala-OH
    • (S)-N-methylalanine
    • N-
    • A-Methyl-L-alanine
    • H5152L2RBJ
    • GDFAOVXKHJXLEI-VKHMYHEASA-N
    • Alanine, N-methyl-, L-
    • H-N-Me-D-Ala-OH
    • n-alpha-methyl-l-alanine
    • N-methlyalanine
    • methyl-l-alanine
    • N-methyl-l-ala
    • N-Methyl alanine
    • L-N-Methylalanine
    • Methylalanine, dl-
    • N-Me-Ala-OH.HCl
    • N-Me-L-Ala
    • DL-
    • N-M
    • M2436
    • UNII-FER5I9LLG2
    • AKOS006237896
    • (2S)-2-(methylamino)propionic acid
    • SCHEMBL23315
    • (s)-2-methylamino-propionic acid
    • .alpha.-(Methylamino)propionic acid
    • N-Methyl-L-alanine, >=98.0% (TLC)
    • (2S)-2-(methylazaniumyl)propanoate
    • MFCD00037241
    • FER5I9LLG2
    • BDBM50357227
    • C02721
    • HY-W015926
    • DTXSID30959936
    • CHEBI:17519
    • AS-18869
    • 2-(Methylamino)propionic acid
    • (2S)-2-methylaminopropanoic acid
    • EN300-49252
    • 3913-67-5
    • CS-W016642
    • UNII-H5152L2RBJ
    • a-(Methylamino)propionic acid
    • (S)-2-methylaminopropanoic acid
    • N-METHYLALANINE, (+)-
    • AM81482
    • AKOS015850626
    • Q27102436
    • (6S)-4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridin-5-ium-6-carboxylate
    • CHEMBL1234201
    • DL-Alanine, N-methyl-
    • A832575
    • (S)-2-(Methylamino)propanoic Acid; (S)-N-Methylalanine; 2-(Methylamino)propanoic Acid; N-Methylalanine; alpha-(Methylamino)propionic Acid
    • 1ST170732
    • MDL： MFCD00037241
    • Inchi： 1S/C4H9NO2/c1-3(5-2)4(6)7/h3,5H,1-2H3,(H,6,7)/t3-/m0/s1
    • InChI Key： GDFAOVXKHJXLEI-VKHMYHEASA-N
    • SMILES： OC([C@H](C)NC)=O
    • BRN： 1720922

Computed Properties

  • Exact Mass: 103.06300
  • Monoisotopic Mass: 103.063329
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 7
  • Rotatable Bond Count: 2
  • Complexity: 72.1
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: -2.5
  • Topological Polar Surface Area: 49.3

Experimental Properties

  • Density: 1.048
  • Melting Point: 280-310°C
  • Boiling Point: 190.1℃ at 760 mmHg
  • Flash Point: 68.8 °C
  • Refractive Index: 1.405
  • PSA: 49.33000
  • LogP: 0.06980
  • Specific Rotation: +4.0 - +6.0° (c=2, H2O)

H-N-Me-Ala-OH Security Information

H-N-Me-Ala-OH Customs Data

  • HS CODE：2922499990
  • Customs Data：

    China Customs Code:

    2922499990

    Overview:

    2922499990 Other amino acids and their esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods) MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Regulatory conditions:

    A.Customs clearance form for Inbound Goods
    B.Customs clearance form for outbound goods

    Inspection and quarantine category:

    P.Imported animals and plants\Quarantine of animal and plant products
    Q.Outbound animals and plants\Quarantine of animal and plant products
    R.Sanitary supervision and inspection of imported food
    S.Sanitary supervision and inspection of exported food
    M.Import commodity inspection
    N.Export commodity inspection

    Summary:

    HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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H-N-Me-Ala-OH Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:3913-67-5)H-N-Me-Ala-OH
Order Number:A824422
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 05:20
Price ($):314.0
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
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(CAS:3913-67-5)N-Methyl-L-alanine
Order Number:LE16629
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:14
Price ($):discuss personally

H-N-Me-Ala-OH Related Literature

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Additional information on H-N-Me-Ala-OH

Recent Advances in the Study of 3913-67-5 and H-N-Me-Ala-OH in Chemical Biology and Pharmaceutical Research

The chemical compound with CAS number 3913-67-5, also known as H-N-Me-Ala-OH (N-Methyl-L-alanine), has garnered significant attention in recent years due to its versatile applications in peptide synthesis, drug development, and biochemical research. This research brief aims to synthesize the latest findings related to this compound, highlighting its structural properties, synthetic methodologies, and potential therapeutic applications.

Recent studies have focused on the role of H-N-Me-Ala-OH as a non-proteinogenic amino acid in the design of peptidomimetics and bioactive peptides. Its unique N-methylation confers enhanced metabolic stability and membrane permeability, making it a valuable building block in the development of peptide-based therapeutics. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in improving the pharmacokinetic profiles of cyclic peptides targeting protein-protein interactions.

In the context of synthetic chemistry, novel methodologies for the efficient production of 3913-67-5 have been explored. A team at MIT recently reported a catalytic asymmetric synthesis approach using chiral palladium complexes, achieving high enantioselectivity (ee > 99%) and yield (92%). This advancement addresses previous challenges in the large-scale production of enantiomerically pure H-N-Me-Ala-OH, which is critical for pharmaceutical applications.

The compound's potential in drug discovery has been further illuminated by its incorporation into antimicrobial peptides. Research from the University of Tokyo (2024) showed that H-N-Me-Ala-OH-containing peptides exhibited potent activity against multidrug-resistant Gram-negative bacteria, with minimal cytotoxicity. This finding opens new avenues for addressing the global antibiotic resistance crisis.

From a structural biology perspective, nuclear magnetic resonance (NMR) studies have revealed that the N-methyl group in H-N-Me-Ala-OH induces specific conformational restraints in peptide chains. These constraints are being exploited to design constrained peptides with improved target binding specificity, as demonstrated in recent work on GPCR-targeting therapeutics published in Nature Chemical Biology.

Looking forward, the unique properties of 3913-67-5/H-N-Me-Ala-OH continue to inspire innovative applications across multiple domains of chemical biology. Current research directions include its use in PROTAC (proteolysis targeting chimera) design, where its structural features may enhance proteasome recruitment efficiency, and in the development of peptide-drug conjugates for targeted cancer therapy.

3913-67-5 (H-N-Me-Ala-OH) Related Products

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Amadis Chemical Company Limited
(CAS:3913-67-5)H-N-Me-Ala-OH
A824422
Purity:99%
Quantity:500g
Price ($):314.0
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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:3913-67-5)N-Methyl-L-alanine
LE16629
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
Email