Cas no 914950-77-9 (1-(6-bromopyridin-2-yl)ethan-1-amine)

1-(6-Bromopyridin-2-yl)ethan-1-amine is a brominated pyridine derivative featuring an amine functional group at the α-position relative to the pyridine ring. This compound serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical applications. The presence of both a reactive bromine substituent and an amine group enables selective functionalization, making it valuable for cross-coupling reactions, nucleophilic substitutions, and heterocyclic scaffold construction. Its stable pyridine core ensures compatibility with a range of reaction conditions. The compound is typically handled under inert conditions due to the amine's sensitivity to oxidation. It is commonly used in the development of bioactive molecules and ligand systems.
1-(6-bromopyridin-2-yl)ethan-1-amine structure
914950-77-9 structure
Product Name:1-(6-bromopyridin-2-yl)ethan-1-amine
CAS No:914950-77-9
MF:C7H9BrN2
MW:201.063760519028
MDL:MFCD13188876
CID:2185021
PubChem ID:60133676
Update Time:2025-05-21

1-(6-bromopyridin-2-yl)ethan-1-amine Chemical and Physical Properties

Names and Identifiers

    • 1-(6-Bromo-2-pyridyl)ethylamine
    • 1-(6-bromopyridin-2-yl)ethanamine
    • 6-Bromo-α-methyl-2-pyridinemethanamine (ACI)
    • 1-(6-Bromopyridin-2-yl)ethan-1-amine
    • 1-(6-bromopyridin-2-yl)ethan-1-amine
    • MDL： MFCD13188876
    • Inchi： 1S/C7H9BrN2/c1-5(9)6-3-2-4-7(8)10-6/h2-5H,9H2,1H3
    • InChI Key： NVMOBBCPDRYXDX-UHFFFAOYSA-N
    • SMILES： BrC1C=CC=C(C(C)N)N=1

1-(6-bromopyridin-2-yl)ethan-1-amine Pricemore >>

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1-(6-bromopyridin-2-yl)ethan-1-amine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Ammonium acetate ,  Sodium cyanoborohydride Solvents: Methanol ;  24 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 10, rt
Reference
Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase
Kong, Weixi; et al, Angewandte Chemie, 2022, 61(21),

Production Method 2

Reaction Conditions
1.1 Reagents: Zinc Solvents: Trifluoroacetic acid
Reference
Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)
Watterson, Scott H.; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(23), 7006-7012

Production Method 3

Reaction Conditions
1.1 Reagents: Hydroxyamine hydrochloride Solvents: Pyridine
2.1 Reagents: Zinc Solvents: Trifluoroacetic acid
Reference
Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)
Watterson, Scott H.; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(23), 7006-7012

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