Production Method 1

906660-35-3

913297-44-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrogen peroxide Solvents: Water ;  < 15 °C; 1 h, 10 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  1 h, pH 4, 10 °C
1.3 Reagents: Diisopropylethylamine ,  Diphenylphosphoryl azide Solvents: Dimethylformamide ;  75 °C; 1 h, 75 °C
1.4 Solvents: Water ;  rt; 1 h, 5 °C

Reference

Process Development of a CRF1 Receptor Antagonist Based on the Selective Chlorination of a Benzimidazolone via Chlorine Migration

Sawai, Yasuhiro ; Yabe, Osamu; Nakaoka, Keiichiro; Ikemoto, Tomomi, Organic Process Research & Development, 2017, 21(2), 222-230

Production Method 2

851886-92-5

913297-44-6

Reaction Conditions

1.1 Reagents: tert-Butyl nitrite ,  Copper bromide (CuBr2) Solvents: Dimethylformamide ;  0 °C; 8 h, rt

Reference

Discovery of a 7-arylaminobenzimidazole series as novel CRF1 receptor antagonists

Mochizuki, Michiyo; Kori, Masakuni; Kono, Mitsunori; Yano, Takahiko; Sako, Yuu; et al, Bioorganic & Medicinal Chemistry, 2016, 24(19), 4675-4691

7-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one Raw materials

• 7-amino-1,3-dihydro-1-methyl-2H-Benzimidazol-2-one
• 7-Bromo-1-methylindoline-2,3-dione

7-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one Preparation Products

• 7-Bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (913297-44-6)

• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 4. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• 305790-48-1(6-Bromo-1-methyl-1H-benzodimidazol-2(3H)-one)
• 39513-26-3(5-bromo-2,3-dihydro-1H-1,3-benzodiazol-2-one)
• 79759-43-6(2H-Benzimidazol-2-one,5-bromo-1,3-dihydro-1-methyl-3-phenyl-)
• 81106-50-5(Urea, N'-(2-bromophenyl)-N,N-dimethyl-)
• 24786-52-5(5-Amino-6-bromo-1,3-dimethyl-1H-benzo[d]imidazol-2(3H)-one)
• 175278-34-9(N,N'-Di-(2-bromophenyl)urea)
• 5269-25-0(1-(2-bromophenyl)-3-phenylurea)
• 79759-42-5(6-bromo-1-phenyl-1,3-dihydro-2H-benzimidazol-2-one)
• 40644-16-4(4-bromo-1,3-dihydrobenzimidazol-2-one)
• 84712-08-3(5-Bromo-1-methyl-3H-1,3-benzodiazol-2-one)