- Stereoselective Preparation of a Cyclopentane-Based NK1 Receptor Antagonist Bearing an Unsymmetrically Substituted Sec-Sec EtherKuethe, Jeffrey T.; Marcoux, Jean-Francois; Wong, Audrey; Wu, Jimmy; Hillier, Michael C.; et al, Journal of Organic Chemistry, 2006, 71(19), 7378-7390
Cas no 912807-35-3 (Tert-butyl (3R)-piperidine-3-carboxylate)
912807-35-3 structure
Product Name:Tert-butyl (3R)-piperidine-3-carboxylate
CAS No:912807-35-3
MF:C10H19NO2
MW:185.26336312294
MDL:MFCD20690120
CID:4777219
PubChem ID:6558861
Update Time:2026-02-27
Tert-butyl (3R)-piperidine-3-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- tert-butyl (3R)-piperidine-3-carboxylate
- (R)-Piperidine-3-carboxylic acid tert-butyl ester
- t-Butyl (R)-piperidine-3-carboxylate
- SB39861
- Piperidine-3alpha-carboxylic acid tert-butyl ester
- 1,1-Dimethylethyl (3R)-3-piperidinecarboxylate (ACI)
- (R)-tert-Butyl Nipecotate
- Tert-butyl (3R)-piperidine-3-carboxylate
-
- MDL： MFCD20690120
- Inchi： 1S/C10H19NO2/c1-10(2,3)13-9(12)8-5-4-6-11-7-8/h8,11H,4-7H2,1-3H3/t8-/m1/s1
- InChI Key： RHNAXBBEIVHVQT-MRVPVSSYSA-N
- SMILES： C([C@H]1CNCCC1)(=O)OC(C)(C)C
Computed Properties
- Exact Mass: 185.141578849 g/mol
- Monoisotopic Mass: 185.141578849 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 13
- Rotatable Bond Count: 3
- Complexity: 184
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Molecular Weight: 185.26
- XLogP3: 0.7
- Topological Polar Surface Area: 38.3
Tert-butyl (3R)-piperidine-3-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 20R1786-1g |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 97% | 1g |
4223.25CNY | 2021-05-07 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 20R1786-5g |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 97% | 5g |
14840.74CNY | 2021-05-07 | |
| abcr | AB543312-250 mg |
t-Butyl (R)-piperidine-3-carboxylate; . |
912807-35-3 | 250mg |
€734.60 | 2023-06-14 | ||
| abcr | AB543312-1 g |
t-Butyl (R)-piperidine-3-carboxylate; . |
912807-35-3 | 1g |
€1554.00 | 2023-06-14 | ||
| eNovation Chemicals LLC | Y1122880-100mg |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 95% | 100mg |
$340 | 2024-07-28 | |
| eNovation Chemicals LLC | Y1122880-250mg |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 95% | 250mg |
$455 | 2024-07-28 | |
| eNovation Chemicals LLC | Y1122880-500mg |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 95% | 500mg |
$665 | 2024-07-28 | |
| eNovation Chemicals LLC | Y1122880-1g |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 95% | 1g |
$985 | 2024-07-28 | |
| eNovation Chemicals LLC | Y1122880-5g |
(R)-Piperidine-3-carboxylic acid tert-butyl ester |
912807-35-3 | 95% | 5g |
$3940 | 2024-07-28 | |
| Enamine | EN300-345476-0.05g |
tert-butyl (3R)-piperidine-3-carboxylate |
912807-35-3 | 95.0% | 0.05g |
$660.0 | 2025-03-18 |
Tert-butyl (3R)-piperidine-3-carboxylate Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol , Ethyl acetate ; 8 h, 20 psi
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Perchloric acid Solvents: Water ; cooled; overnight, rt
Reference
- Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-LactamasesBuettner, Dominik; Kramer, Jan S.; Klingler, Franca-M.; Wittmann, Sandra K.; Hartmann, Markus R.; et al, ACS Infectious Diseases, 2018, 4(3), 360-372
Tert-butyl (3R)-piperidine-3-carboxylate Raw materials
- (3R)-piperidine-3-carboxylic acid
- 3-(1,1-Dimethylethyl) 1-(phenylmethyl) (3R)-1,3-piperidinedicarboxylate
Tert-butyl (3R)-piperidine-3-carboxylate Preparation Products
Tert-butyl (3R)-piperidine-3-carboxylate Related Literature
-
H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
-
Wenjie Zhao,Hua Hou,Yuchun Jin,Zhixiang Zeng,Xuedong Wu,Qunji Xue RSC Adv., 2014,4, 60307-60315
-
Ying Li,Weirong Yao,Yunfei Xie,Renjun Pei RSC Adv., 2015,5, 98724-98729
-
Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
912807-35-3 (Tert-butyl (3R)-piperidine-3-carboxylate) Related Products
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- 301180-05-2(tert-butyl piperidine-3-carboxylate)
- 1343192-59-5(TERT-BUTYL 3-METHYLPIPERIDINE-3-CARBOXYLATE)
- 2089245-14-5(tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride)
- 1307815-43-5(tert-butyl (3S)-piperidine-3-carboxylate)
- 1339626-73-1(tert-butyl 3-ethylpiperidine-3-carboxylate)
- 2639392-07-5(rac-tert-butyl (3R,4R)-4-(piperidin-4-yl)pyrrolidine-3-carboxylate)
- 2639374-97-1(rac-tert-butyl (3R,5S)-5-tert-butylpiperidine-3-carboxylate)
- 1172835-68-5(RS-3-Piperidinecarboxylic acid1,1-dimethylethyl ester hydrochloride)
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