Cas no 2089245-14-5 (tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride)
tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride Chemical and Physical Properties
Names and Identifiers
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- tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride
- AT21702
- tert-butyl (3R)-piperidine-3-carboxylate;hydrochloride
- TERT-BUTYL (R)-PIPERIDINE-3-CARBOXYLATE HYDROCHLORIDE
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- MDL: MFCD30537773
- Inchi: 1S/C10H19NO2.ClH/c1-10(2,3)13-9(12)8-5-4-6-11-7-8;/h8,11H,4-7H2,1-3H3;1H/t8-;/m1./s1
- InChI Key: FNTUZXRGYYMCBP-DDWIOCJRSA-N
- SMILES: Cl.O(C(C)(C)C)C([C@H]1CNCCC1)=O
Computed Properties
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 14
- Rotatable Bond Count: 3
- Complexity: 184
- Topological Polar Surface Area: 38.3
tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM470018-100mg |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95%+ | 100mg |
$259 | 2022-09-01 | |
| Chemenu | CM470018-250mg |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95%+ | 250mg |
$362 | 2022-09-01 | |
| Chemenu | CM470018-500mg |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95%+ | 500mg |
$662 | 2022-09-01 | |
| Chemenu | CM470018-1g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95%+ | 1g |
$844 | 2022-09-01 | |
| Enamine | EN300-345475-0.05g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95% | 0.05g |
$179.0 | 2023-09-03 | |
| Enamine | EN300-345475-0.1g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95% | 0.1g |
$268.0 | 2023-09-03 | |
| Enamine | EN300-345475-0.25g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95% | 0.25g |
$383.0 | 2023-09-03 | |
| Enamine | EN300-345475-0.5g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95% | 0.5g |
$601.0 | 2023-09-03 | |
| Enamine | EN300-345475-1.0g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95% | 1g |
$0.0 | 2023-06-07 | |
| Enamine | EN300-345475-2.5g |
tert-butyl (3R)-piperidine-3-carboxylate hydrochloride |
2089245-14-5 | 95% | 2.5g |
$1509.0 | 2023-09-03 |
tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride Related Literature
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Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
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Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
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Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
Additional information on tert-Butyl (3R)-piperidine-3-carboxylate hydrochloride
Introduction to Tert-Butyl (3R)-Piperidine-3-Carboxylate Hydrochloride (CAS No. 2089245-14-5)
Ter-t-butyl (3R)-piperidine-3-carboxylate hydrochloride, a compound with the chemical identifier CAS No. 2089245-14-5, represents a significant advancement in the field of pharmaceutical chemistry. This compound, characterized by its unique structural and functional properties, has garnered considerable attention in recent years due to its potential applications in drug development and medicinal chemistry. The hydrochloride salt form of this piperidine derivative enhances its solubility and bioavailability, making it a promising candidate for various therapeutic interventions.
The molecular structure of tert-butyl (3R)-piperidine-3-carboxylate hydrochloride consists of a piperidine ring substituted with a tert-butyl group at the 3-position and a carboxylate group at the 3-position, further stabilized by the hydrochloride salt. This configuration imparts distinct pharmacokinetic and pharmacodynamic properties, which have been extensively studied in recent research. The stereochemistry, specifically the (3R) configuration, plays a crucial role in determining the compound's interactions with biological targets, making it an attractive scaffold for developing enantioselective drugs.
In recent years, there has been a surge in research focusing on piperidine derivatives due to their versatility in drug design. Piperidines are known for their ability to mimic natural amino acid structures, which facilitates strong binding to biological receptors. The tert-butyl group enhances metabolic stability, reducing the likelihood of rapid degradation in vivo. This stability is particularly important for drugs that require prolonged half-life to achieve therapeutic efficacy.
The carboxylate group in tert-butyl (3R)-piperidine-3-carboxylate hydrochloride contributes to its amphiphilic nature, allowing it to interact effectively with both hydrophobic and hydrophilic environments. This property is advantageous for designing drugs that need to traverse biological membranes while maintaining stability in aqueous environments. The hydrochloride form further improves solubility, which is critical for formulation development and ensuring optimal drug delivery.
Recent studies have highlighted the potential of this compound in addressing various therapeutic challenges. For instance, researchers have explored its utility in developing kinase inhibitors, which are essential for treating cancers and inflammatory diseases. The unique steric hindrance provided by the tert-butyl group can selectively target specific kinases while minimizing off-target effects. This specificity is crucial for improving drug safety and efficacy.
Another area of interest is the application of tert-butyl (3R)-piperidine-3-carboxylate hydrochloride in central nervous system (CNS) drug development. Piperidine derivatives have shown promise as substrates or inhibitors of neurotransmitter receptors, making them valuable candidates for treating neurological disorders such as depression, anxiety, and Parkinson's disease. The (3R) configuration enhances binding affinity to certain receptors, potentially leading to more effective treatments with fewer side effects.
The compound's potential extends beyond oncology and CNS disorders. Emerging research suggests its applicability in antiviral and antibacterial therapies. The structural features of this molecule allow it to interfere with viral protease activity or bacterial enzyme function, offering new avenues for combating resistant strains of pathogens. Such findings underscore the importance of continued investigation into piperidine-based compounds.
In conclusion, tert-butyl (3R)-piperidine-3-carboxylate hydrochloride represents a versatile and promising compound in pharmaceutical chemistry. Its unique structural attributes, combined with its enhanced solubility and bioavailability, make it an attractive candidate for various therapeutic applications. Ongoing research continues to uncover new possibilities for this compound, reinforcing its significance in the development of next-generation drugs.
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