Production Method 1

2032-35-1

59489-71-3

912773-24-1

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Water ;  2 h, 70 °C; 70 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Isopropanol
1.3 2 h, 70 °C; 70 °C → rt
1.4 Reagents: Sodium bicarbonate Solvents: Water

Reference

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

Le Manach, Claire; Paquet, Tanya; Brunschwig, Christel; Njoroge, Mathew; Han, Ze; et al, Journal of Medicinal Chemistry, 2015, 58(21), 8713-8722

Production Method 2

2032-35-1

59489-71-3

912773-24-1

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Isopropanol ,  Water ;  3 h, 80 °C; 80 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized, rt

Reference

Discovery of novel (imidazo[1,2-a]pyrazin-6-yl)ureas as antiproliferative agents targeting P53 in non-small cell lung cancer cell lines

Bazln, Marc-Antoine; Roussealt, Benedicte; Marhadour, Sophie; Tomasoni, Christophe; Evenou, Pierre; et al, Anticancer Research, 2016, 36(4), 1621-1630

Production Method 3

2032-35-1

59489-71-3

912773-24-1

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Ethanol ,  Water ;  8 h, 100 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 7

Reference

Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors

Bu, Hong; Yuan, Xinrui; Wu, Hanshu; Zhou, Jinpei; Zhang, Huibin, Bioorganic & Medicinal Chemistry, 2021, 40,

Production Method 4

7252-83-7

59489-71-3

912773-24-1

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Water ;  2 h, 100 °C
1.2 Reagents: Sodium bicarbonate Solvents: Isopropanol ;  3 h, 100 °C

Reference

Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases

Matthews, Thomas P.; McHardy, Tatiana; Klair, Suki; Boxall, Kathy; Fisher, Martin; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(14), 4045-4049

Production Method 5

7252-83-7

59489-71-3

912773-24-1

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Ethanol ;  12 h, 80 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 9

Reference

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Zheng, Xiaozhang; Bauer, Paul; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; et al, Journal of Medicinal Chemistry, 2013, 56(16), 6413-6433

6-Bromoimidazo[1,2-a]pyrazine Raw materials

• 2-Bromo-1,1-diethoxyethane
• Bromoacetaldehyde dimethyl acetal
• 5-bromopyrazin-2-amine

6-Bromoimidazo[1,2-a]pyrazine Preparation Products

• 6-Bromoimidazo[1,2-a]pyrazine (912773-24-1)

• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 3. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 4. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 5. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrazines Imidazopyrazines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrazines

• 58860-36-9(3-bromodiimidazo[1,2-a:2',1'-c]pyrazine)
• 58860-37-0(3,8-dibromodiimidazo[1,2-a:2',1'-c]pyrazine)
• 63744-24-1(3,6,8-Tribromoimidazo[1,2-a]pyrazine)
• 69214-34-2(8-Bromoimidazo[1,2-a]pyrazine)
• 63744-21-8(3,5-Dibromoimidazo[1,2-a]pyrazine)
• 87597-26-0(5-Bromoimidazo[1,2-a]pyrazine)
• 57948-41-1(3-Bromoimidazo[1,2-a]pyrazine)
• 91225-41-1(5-bromo-1H-imidazo[4,5-b]pyrazine)
• 63744-22-9(6,8-Dibromoimidazo[1,2-a]pyrazine)
• 957344-74-0(5,8-Dibromoimidazo[1,2-a]pyrazine)