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Cas no 911-40-0 (7-keto-Deoxycholic acid)

7-Keto-Deoxycholic Acid is a biologically active metabolite of deoxycholic acid, formed through the oxidation of the 7α-hydroxyl group. This compound is of interest in biochemical and pharmaceutical research due to its role in bile acid metabolism and potential applications in studying metabolic pathways. Unlike deoxycholic acid, 7-Keto-Deoxycholic Acid exhibits altered physicochemical properties, including reduced hydrophobicity, which may influence its interactions with cellular receptors and enzymes. It serves as a valuable reference standard in analytical studies and is utilized in investigations of bile acid-related disorders. Its stability and distinct structural features make it a useful tool for mechanistic research in lipid metabolism and signaling.
7-keto-Deoxycholic acid structure

Product Name:7-keto-Deoxycholic acid

  • CAS No:911-40-0
  • CID:808867
  • MF:C24H38O5
  • MDL:MFCD00271373
  • MW:406.55552816391
  • Update Time:2025-08-03

Chemical and Physical Properties

7-keto-Deoxycholic acid Chemical and Physical Properties

Names and Identifiers
    • Cholan-24-oic acid,3,12-dihydroxy-7-oxo-, (3a,5b,12a)-
    • 3,12-Dihydroxy-7-oxocholan-24-oic acid
    • 3α,12α-dihydroxy-7-keto-5β-cholan-24-oic acid
    • 5B-CHOLANIC ACID-3A,12A-DIOL-7-ONE
    • 5BETA-CHOLANIC ACID-3ALPHA,12ALPHA-DIOL-7-ONE
    • 7-KETO-3A,12A-DIHYDROXYCHOLANIC ACID
    • 7-Keto-3α,12-α-dihydroxycholanic Acid
    • (3alpha,5beta,12alpha)-3,12-Dihydroxy-7-oxocholan-24-oic acid
    • (4R)-4-[(3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
    • 3alpha,12alpha-dihydr
    • 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic Acid
    • 3alpha,12alpha-Diol-7-one-5beta-cholanoic acid
    • 7-ketodeoxycholate
    • 7-Ketodeoxycholic acid
    • 7-oxodeoxycholate
    • 7-Oxodeoxycholic acid
    • (3α,5β,12α)-3,12-Dihydroxy-7-oxocholan-24-oic acid (ACI)
    • 5β-Cholan-24-oic acid, 3α,12α-dihydroxy-7-oxo- (8CI)
    • 5β-Cholanic acid, 3α,12α-dihydroxy-7-oxo- (7CI)
    • 3α,12α-Dihydroxy-7-keto-5β-cholanic acid
    • 3α,12α-Dihydroxy-7-ketocholanic acid
    • 3α,12α-Dihydroxy-7-oxo-5β-cholan-24-oic acid
    • 3α,12α-Dihydroxy-7-oxo-5β-cholanoic acid
    • 5β-Cholanic acid-3α,12α-diol-7-one
    • 7-keto-3α,12α-Dihydroxy-5β-cholanic acid
    • 7-keto-Deoxycholic acid
    • 7-Oxo-3α,12α-dihydroxy-5β-cholanoic acid
    • 7-Oxo-3α,12α-dihydroxycholan-24-oic acid
    • MFCD00271373
    • 7-Keto-3
    • CHEMBL3392000
    • 3alpha, 12alpha-dihydroxy-7-keto-5beta-cholanoic acid
    • 3 alpha,12 alpha-diol-7-one-5 beta-cholanoic acid
    • Cholan-24-oic acid, 3,12-dihydroxy-7-oxo-, (3.alpha.,5.beta.,12.alpha.)-
    • (3a,5b,12a)-3,12-dihydroxy-7-oxo-Cholan-24-oate
    • 3alpha,12alpha-Dihydroxy-7-keto-5beta-cholanic Acid
    • 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid
    • 7-Keto-DCA
    • NS00124973
    • HY-41324
    • RHCPKKNRWFXMAT-RRWYKFPJSA-N
    • 3 alpha,7 alpha-dihydroxy-7-keto-5 beta-cholanoic acid
    • SCHEMBL1653937
    • UNII-14DEP88BGS
    • Cholan-24-oic acid, 3,12-dihydroxy-7-oxo-, (3a,5b,12a)-
    • (R)-4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-Dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
    • 14DEP88BGS
    • 7-Keto-3alpha,12alpha-dihydroxycholanic acid;7-Keto-3a,12-a-dihydroxycholanic Acid;3a,12a-dihydroxy-7-keto-5?-cholan-24-oic acid
    • 3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid
    • CS-0016034
    • 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid
    • 5.BETA.-CHOLAN-24-OIC ACID, 3.ALPHA.,12.ALPHA.-DIHYDROXY-7-OXO-
    • 911-40-0
    • (3alpha,5beta,12alpha)-3,12-Dihydroxy-7-oxo-cholan-24-oic Acid
    • 3alpha,7alpha-Dihydroxy-7-keto-5beta-cholanoic acid
    • 3 alpha,7 alpha-dihydroxy-7-keto-5 beta-cholanoate
    • Q27101883
    • PD166097
    • 7-Keto-3a,12-a-dihydroxycholanic Acid
    • 7-Keto-3alpha,12-alpha-dihydroxycholanic acid
    • 7-Keto-3 alpha ,12- alpha -dihydroxycholanic Acid
    • V10233
    • 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanoic acid
    • C04643
    • 3 alpha,12 alpha-diol-7-one-5 beta-cholanoate
    • AS-54739
    • 3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanoate
    • A,12-
    • 7-Keto-3 alpha ,12 alpha -dihydroxy-5 alpha -cholanic Acid
    • 7-Ketocholate
    • 7-Keto-3?,12-?-dihydroxycholanic Acid
    • DA-70356
    • 3a,12a-dihydroxy-7-oxo-5b-cholan-24-oate
    • (3a,5b,12a)-3,12-dihydroxy-7-oxo-Cholan-24-oic acid
    • 5.BETA.-CHOLANIC ACID, 3.ALPHA.,12.ALPHA.-DIHYDROXY-7-OXO-
    • DTXSID101314217
    • LMST04010184
    • CHEBI:16390
    • A-dihydroxycholanic Acid
    • AKOS027381854
    • MDL： MFCD00271373
    • Inchi： 1S/C24H38O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-18,20,22,25,27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,20+,22+,23+,24-/m1/s1
    • InChI Key： RHCPKKNRWFXMAT-RRWYKFPJSA-N
    • SMILES： O=C1C[C@@H]2C[C@@H](CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCC(=O)O)[C@]1([C@H](C2)O)C)O
Computed Properties
    • Exact Mass: 406.27200
    • Monoisotopic Mass: 406.271924
    • Isotope Atom Count: 0
    • Hydrogen Bond Donor Count: 3
    • Hydrogen Bond Acceptor Count: 5
    • Heavy Atom Count: 29
    • Rotatable Bond Count: 4
    • Complexity: 676
    • Covalently-Bonded Unit Count: 1
    • Defined Atom Stereocenter Count: 10
    • Undefined Atom Stereocenter Count : 0
    • Defined Bond Stereocenter Count: 0
    • Undefined Bond Stereocenter Count: 0
    • Topological Polar Surface Area: 94.8
    • XLogP3: 3.3
Experimental Properties
    • Density: 1.18
    • Melting Point: 54-60°C
    • Boiling Point: 583°Cat760mmHg
    • Flash Point: 320.4°C
    • Refractive Index: 1.55
    • PSA: 94.83000
    • LogP: 3.65690

7-keto-Deoxycholic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: N-Bromosuccinimide ,  Sodium bicarbonate Solvents: Acetone ,  Water ;  rt → 85 °C
Reference
Synthesis of 6α- and 6β-hydroxydeoxycholic acid
Niu, Wei; Xiao, Dan; Cheng, Hang; Xu, Liang, Youji Huaxue, 2020, 40(7), 2114-2119

Production Method 2

Reaction Conditions
1.1 Reagents: Oxalacetate Catalysts: 7α-Hydroxysteroid dehydrogenase ,  7β-Hydroxysteroid dehydrogenase (NADP) Solvents: Methanol ,  Water ;  1 h, pH 8, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, 25 °C
Reference
NAD+-Dependent Enzymatic Route for the Epimerization of Hydroxysteroids
Tonin, Fabio ; Otten, Linda G.; Arends, Isabel W. C. E., ChemSusChem, 2019, 12(13), 3192-3203

7-keto-Deoxycholic acid Raw materials

7-keto-Deoxycholic acid Preparation Products

911-40-0 (7-keto-Deoxycholic acid) Global Suppliers

Product Overview and Price Analysis

7-Keto-Deoxycholic Acid is a derivative of deoxycholic acid, a secondary bile acid. It is a key intermediate in steroid metabolism and is used in research and pharmaceutical synthesis. Its keto group at the C7 position makes it a valuable precursor for various biochemical applications.

CAS no.911-40-0 comprehensive analysis

+View Details

Based on available supplier data, prices for 7-Keto-Deoxycholic Acid vary significantly depending on purity, quantity, and supplier location. High-purity research-grade material commands a premium. Prices are generally stable but can fluctuate with raw material costs and demand from the pharmaceutical sector.

The main factors affecting prices include:

  • Purity and grade (e.g., analytical vs. industrial)
  • Order quantity and packaging specifications
  • Supplier location and associated logistics costs
  • Market demand from pharmaceutical and research sectors
  • Complexity of synthesis and availability of raw materials

High quality verification supplier (strong customization capability)

Amadis Chemical Company Limited

Amadis Chemical Company Limited

Gold Member
Audited Supplier Audited Supplier
浙江, CN
Founded in 2011, Amadis Chemical is an innovative manufacturer and service provider specializing in high-quality carbohydrates, nucleosides, nucleotides, phosphoramidites, APIs, and pharmaceutical intermediates.

(CAS:911-40-0)7-keto-Deoxycholic acid

  • Order Number: A846728
  • Quantity: 50mg/100mg
  • Price ($): 326.0/501.0
  • Stock Status: in Stock
  • Purity: 99%
  • Last Updated: Friday, 30 August
Tiancheng Chemical (Jiangsu) Co., Ltd

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member
Audited Supplier Audited Supplier
江蘇, CN
Tiancheng Chemical is a high-tech enterprise specializing in R&D, production, and sales of eco-friendly fine chemicals, including UV resins and specialty solvents for electronics and new materials.

(CAS:911-40-0)7-Ketodeoxycholic acid

  • Order Number: LE11684
  • Quantity: 25KG,200KG,1000KG
  • Price ($): discuss personally
  • Stock Status: in Stock
  • Purity: 99%
  • Last Updated: Friday, 20 June
SHOCHEM(SHANGHAI) CO.,lTD

SHOCHEM(SHANGHAI) CO.,lTD

Gold Member
Audited Supplier Audited Supplier
上海, CN
SHOCHEM is a high-tech enterprise specializing in pharmaceutical R&D, focusing on camptothecin derivatives, lipid-based nucleic acid delivery excipients, and high-purity synthetic phospholipids.

(CAS:911-40-0)7-Keto-3α,12α-dihydroxycholanic Acid

  • Order Number: 0246
  • Quantity: 100mg;500mg;1g
  • Price ($):
  • Stock Status: in Stock
  • Purity: 98%min
  • Last Updated: Thursday, 21 August

7-keto-Deoxycholic acid Research More >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
K188480-50mg
7-Keto-3a,12-a-dihydroxycholanic Acid
 911-40-0
50mg
 $ 249.00 2023-09-07
TRC
K188480-100mg
7-Keto-3a,12-a-dihydroxycholanic Acid
 911-40-0
100mg
 $ 460.00 2023-09-07
TRC
K188480-250mg
7-Keto-3a,12-a-dihydroxycholanic Acid
 911-40-0
250mg
 $ 862.00 2023-09-07
TRC
K188480-500mg
7-Keto-3a,12-a-dihydroxycholanic Acid
 911-40-0
500mg
 $ 1246.00 2023-04-15
TRC
K188480-1g
7-Keto-3a,12-a-dihydroxycholanic Acid
 911-40-0
1g
 $ 2193.00 2023-04-15
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
K924028-1g
7-Keto-3α,12-α-dihydroxycholanic Acid
 911-40-0 97%
1g
 ￥3,404.70 2022-01-10
abcr
AB496499-250 mg
3,12-Dihydroxy-7-oxocholan-24-oic acid
 911-40-0
250MG
 €382.00 2021-09-16
abcr
AB496499-1 g
3,12-Dihydroxy-7-oxocholan-24-oic acid; .
 911-40-0
1g
 €594.50 2023-07-10
1PlusChem
1P006R4H-1g
3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid
 911-40-0 90%
1g
 $433.00 2024-04-20
1PlusChem
1P006R4H-5g
3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid
 911-40-0 90%
5g
 $1848.00 2024-04-20

Comparison of Global Market Sizes

Based on the analysis of relevant compound market data, the performance of the segmented market to which CAS No. (911-40-0) belongs is as follows:
Market category Market size Growth rate(CAGR) Main driving factors
Global Bile Acid Derivatives Market —— —— Growing pharmaceutical R&D
Increasing demand for steroid intermediates
Steroid and Hormone Intermediates Market —— —— Expanding therapeutic applications
Advancements in synthetic pathways
Specialty Fine Chemicals Market —— —— Custom synthesis demand
High-value niche applications
7-Keto-Deoxycholic Acid (Estimated) —— —— Research tool demand
Potential new pharmaceutical uses

911-40-0 (7-keto-Deoxycholic acid) Related Products

7-keto-Deoxycholic acid Analysis

Analysis of Regional Market Characteristics and Demand

Geographical distribution characteristics
Production Distribution
Primary production is concentrated in regions with strong fine chemical and pharmaceutical API capabilities.
Key manufacturers are often located in China, India, and Europe, leveraging cost and expertise advantages.
Production requires specialized facilities for handling steroid intermediates under controlled conditions.
Consumption Distribution
Major consumption driven by pharmaceutical R&D hubs in North America, Europe, and parts of Asia.
Academic and research institutions constitute a significant portion of demand for high-purity material.
Demand is linked to the pipeline of steroid-related drug development projects globally.
European Market
Characterized by stringent REACH and pharmaceutical quality regulations for chemical intermediates.
Demand is steady from established pharmaceutical and biotechnology research clusters.
Suppliers emphasize documentation, traceability, and compliance with GMP-related standards.
Asia-Pacific Market
Exhibits growth potential due to expanding pharmaceutical R&D and manufacturing outsourcing.
China and India are significant as both production bases and growing consumption markets.
Competitive pricing is a key feature, but quality consistency can vary among suppliers.

Safety and regulatory requirements

Hazard classification
CasNo 911-40-0 is a fine chemical/organic intermediate with potential health and environmental hazards.
May cause skin and eye irritation upon contact; requires proper personal protective equipment.
Potential environmental hazard if released; requires proper disposal methods.
Dust may form explosive mixtures with air; requires handling in well-ventilated areas.
Storage and transportation requirements
Storage conditions: Store in a cool, dry, well-ventilated place away from incompatible materials. Keep container tightly closed.
Transportation classification: Classified based on specific hazard data; may fall under general provisions for environmentally hazardous substances.
Packaging requirements: Use appropriate, sealed containers (e.g., glass or compatible plastic) to prevent contamination and moisture ingress.
Identification requirements: Containers must be clearly labeled with product name, CAS number, hazard pictograms (if applicable), and risk/safety phrases.

Supply chain risk assessment

Geographic Concentration Risk
Production is somewhat concentrated, leading to potential disruption risks from regional events.
Dependence on specific regions for key raw materials (e.g., bile acids) could create bottlenecks.
Logistics from primary production regions may face delays or increased costs.
Compliance Risk
Must comply with varying international chemical regulations (REACH, TSCA, etc.).
Pharmaceutical-grade applications require adherence to strict quality and documentation standards.
Changing environmental and safety regulations may impact production processes or costs.
Technical Risk
Synthesis involves multiple steps, requiring specialized expertise and equipment.
Quality control is critical, especially for purity and impurity profiles in research applications.
Scale-up from lab to commercial production can present technical challenges.
Market Risk
Demand is niche and can be volatile, tied to specific research trends or drug development projects.
Competition from alternative synthetic pathways or similar intermediates may affect pricing.
Long lead times for high-purity custom synthesis can impact supply responsiveness.

Procurement Suggestions and Strategies

Supplier selection strategy
Top Choice: ——
Prioritize suppliers with a proven track record in producing high-purity steroid intermediates, offering comprehensive technical data (CoA, MSDS), and demonstrating compliance with major regulatory frameworks (e.g., REACH, cGMP for relevant applications).

Alternative Option: ——
Consider established fine chemical distributors or manufacturers with reliable supply chains and good customer support. They should offer material with consistent quality suitable for your intended application tier (research vs. development).

Cost Optimization: ——
For non-critical applications or larger bulk orders, evaluate suppliers offering competitive pricing, especially from regions with cost advantages. Ensure basic quality specifications are met and conduct due diligence on their reliability and quality control processes.

Procurement execution suggestions
Pre-Procurement Preparation:
Clearly define required purity grade, quantity, and packaging specifications.
Research and shortlist potential suppliers based on credibility and product suitability.
Prepare a list of required documentation (CoA, MSDS, regulatory compliance statements).

Supplier Evaluation & Quotation:
Request and compare detailed quotations, including Incoterms and lead times.
Evaluate supplier-provided technical data and request samples if necessary.
Clarify payment terms, minimum order quantities, and return/refund policies.

Order Placement & Logistics:
Place a trial order for evaluation before committing to large volumes.
Confirm shipping method, tracking, and insurance for the shipment.
Coordinate with receiving department for proper handling and storage upon arrival.

Post-Delivery & Quality Assurance:
Inspect packaging and labeling upon receipt for any damage or discrepancies.
Perform or arrange for quality testing to verify specifications against the CoA.
Maintain records of the purchase, supplier communications, and quality reports.

Conclusion

Procurement of 7-Keto-Deoxycholic Acid requires a balanced strategy prioritizing quality and reliability for research applications, while considering cost for larger-scale or less critical uses. Key to success is thorough supplier vetting, clear specification of requirements, and proactive management of compliance and supply chain risks. Building relationships with reliable suppliers can ensure a steady supply of this specialized intermediate.

Key points:
  • Prioritize suppliers with strong quality control and regulatory documentation.
  • Clearly define purity and application requirements before sourcing.
  • Manage risks related to supply concentration and technical complexity.
  • Consider starting with a trial order to evaluate supplier performance.