Production Method 1

16626-02-1

82911-69-1

908846-88-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Acetone ,  Water ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2

Reference

The facile synthesis of a series of tryptophan derivatives

Blaser, Georg; Sanderson, John M.; Batsanov, Andrei S.; Howard, Judith A. K., Tetrahedron Letters, 2008, 49(17), 2795-2798

Production Method 2

16626-02-1

82911-69-1

908846-88-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  0 °C; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3, rt

Reference

Easy preparation of dehydroalanine building blocks equipped with oxazolidin-2-one chiral auxiliaries, and applications to the stereoselective synthesis of substituted tryptophans

De Marco, Rossella; Cavina, Lorenzo; Greco, Arianna; Gentilucci, Luca, Amino Acids, 2014, 46(12), 2823-2839

Production Method 3

28920-43-6

16626-02-1

908846-88-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Acetone ,  Water ;  1.5 h, 0 °C; 0 °C → rt; 4 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  1.5 h, pH 2, rt

Reference

Photocontrolled chignolin-derived β-hairpin peptidomimetics

Podewin, T.; Rampp, M. S.; Turkanovic, I.; Karaghiosoff, K. L.; Zinth, W.; et al, Chemical Communications (Cambridge, 2015, 51(19), 4001-4004

Production Method 4

1065638-25-6

82911-69-1

908846-88-8

Reaction Conditions

1.1 Reagents: Sodium carbonate ,  Hydrochloric acid Solvents: Acetone ,  Water ;  rt; 30 min, rt; pH 8, rt

Reference

Structure-based design of Melanocortin 4 receptor ligands based on the SHU-9119-hMC4R cocrystal structure

Martin, Charlotte; Gimenez, Luis E.; Williams, Savannah Y.; Jing, Yu; Wu, Yiran; et al, Journal of Medicinal Chemistry, 2021, 64(1), 357-369

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid Raw materials

• (9H-fluoren-9-yl)methyl chloroformate
• (2S)-2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
• (S)-2-Amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid hydrochloride
• Fmoc-OSu

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid Preparation Products

• (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid (908846-88-8)

• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 3. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 4. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 5. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210

• 144701-22-4(2-({(9H-fluoren-9-yl)methoxycarbonyl}amino)-3-(1H-indol-3-yl)propanoic acid)
• 86123-11-7((2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-indol-3-yl)propanoic acid)
• 35737-15-6(Nα-Fmoc-L-tryptophan)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)