Production Method 1

22276-95-5

908287-21-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 1 h, -78 °C
1.2 -78 °C; 30 min, -78 °C; overnight, rt
1.3 Reagents: Water ;  rt

Reference

Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold

Jung, Eunkyung; Soto-Acosta, Ruben; Geraghty, Robert J. ; Chen, Liqiang, Molecules, 2022, 27(18),

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde Raw materials

• 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde Preparation Products

• 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde (908287-21-8)

• 1. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 5. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyrimidines Pyrrolo[2,3-d]pyrimidines

Comprehensive Overview of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde (CAS No. 908287-21-8)

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde (CAS No. 908287-21-8) is a heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. This compound belongs to the pyrrolopyrimidine family, a class of nitrogen-containing heterocycles known for their broad biological activities. Researchers are particularly interested in its potential applications as a building block for drug discovery, especially in the development of kinase inhibitors and antiviral agents.

The molecular structure of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde features a chloro substituent at the 4-position and an aldehyde functional group at the 5-position, which makes it a versatile intermediate for further chemical modifications. Its CAS number 908287-21-8 is frequently searched in scientific databases, reflecting its importance in synthetic chemistry. Recent studies highlight its role in the synthesis of small-molecule therapeutics, particularly in oncology and immunology research.

One of the trending topics in the scientific community is the exploration of pyrrolopyrimidine derivatives as potential treatments for chronic inflammatory diseases. Given the rising global prevalence of conditions like rheumatoid arthritis and psoriasis, researchers are investigating how 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde can be utilized to design novel anti-inflammatory agents. Its aldehyde group offers a reactive site for conjugation with other pharmacophores, enhancing drug-like properties.

In addition to its pharmaceutical applications, this compound is also studied for its potential in agrochemical innovation. With increasing demand for sustainable crop protection solutions, scientists are examining its derivatives as candidates for next-generation pesticides. The chloro and aldehyde functionalities provide opportunities for structural optimization to improve efficacy and environmental safety.

From a synthetic chemistry perspective, CAS No. 908287-21-8 is often discussed in forums and publications focusing on heterocyclic compound synthesis. Its preparation typically involves multi-step reactions, including Vilsmeier-Haack formylation and nucleophilic substitution. These methods are critical for researchers aiming to scale up production for industrial applications.

The compound’s stability and solubility profiles are also subjects of ongoing research. Understanding these properties is essential for formulating bioavailable drug candidates. Recent advancements in computational chemistry have enabled predictive modeling of its behavior in biological systems, further accelerating drug development pipelines.

Given the growing interest in personalized medicine, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde is being explored for its potential in targeted therapies. Its modular structure allows for customization to address specific genetic mutations, aligning with the trend toward precision healthcare.

In summary, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde (CAS No. 908287-21-8) is a pivotal compound in modern chemical research. Its applications span from drug discovery to agrochemical development, making it a valuable asset for scientists addressing global health and agricultural challenges. As research progresses, its role in innovative therapeutics and sustainable solutions is expected to expand significantly.

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