Production Method 1

3959-07-7

90561-76-5

Reaction Conditions

1.1 Catalysts: Triacylglycerol lipase Solvents: Toluene ;  2 h, 100 °C

Reference

Synergy between chemo- and bio-catalysts in multi-step transformations

Caiazzo, Aldo; Garcia, Paula M. L.; Wever, Ron; van Hest, Jan C. M.; Rowan, Alan E.; et al, Organic & Biomolecular Chemistry, 2009, 7(14), 2926-2932

Production Method 2

3959-07-7

90561-76-5

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ,  Tetrahydrofuran ;  0 °C; 3 h, 0 °C → rt

Reference

N-Benzylpiperidinol derivatives as novel USP7 inhibitors: structure-activity relationships and X-ray crystallographic studies

Li, Minglei; Liu, Shengjie; Chen, Hui; Zhou, Xinyu; Zhou, Jin; et al, European Journal of Medicinal Chemistry, 2020, 199,

Production Method 3

90561-76-5

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Tetrabutylammonium hexafluorophosphate ,  Water Catalysts: Cyclopropenylium, 1,2,3-tris[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel-, perchlo… Solvents: Acetonitrile ;  48 h, rt

Reference

C-H Amination via Electrophotocatalytic Ritter-type Reaction

Shen, Tao; Lambert, Tristan H., Journal of the American Chemical Society, 2021, 143(23), 8597-8602

Production Method 4

3959-07-7

90561-76-5

Reaction Conditions

1.1 Catalysts: 1,10-Phenanthroline, monohydrate ,  Copper fluoride (CuF2) Solvents: Chlorobenzene ;  40 bar, rt; 24 h, 140 °C

Reference

An unexpected copper-catalyzed carbonylative acetylation of amines

Li, Yahui; Wang, Changsheng; Zhu, Fengxiang; Wang, Zechao; Soule, Jean-Francois; et al, Chemical Communications (Cambridge, 2017, 53(1), 142-144

Production Method 5

90561-76-5

Reaction Conditions

1.1 Reagents: Methanesulfonic acid ,  Ammonia ,  Water Catalysts: Tetrabutylammonium hexafluorophosphate Solvents: Methanol

Reference

Continuous direct anodic flow oxidation of aromatic hydrocarbons to benzyl amides

Kabeshov, Mikhail A.; Musio, Biagia; Ley, Steven V., Reaction Chemistry & Engineering, 2017, 2(6), 822-825

Production Method 6

107047-10-9

90561-76-5

Reaction Conditions

1.1 Reagents: Tetraethylammonium bromide ,  Acetic anhydride Solvents: Acetonitrile

Reference

Cathodic reduction of aliphatic azides and of azides activated by olefinic and carbonyl groups

Knittel, Dierk, Monatshefte fuer Chemie, 1986, 117(5), 679-87

Production Method 7

873-75-6

90561-76-5

Reaction Conditions

1.1 Catalysts: Silica (reaction products with 3-aminopropyltrimethoxysilane and chlorosulfonic acid) ,  Chlorosulfonic acid (reaction products with 3-aminopropyltrimethoxysilane and silica) ,  Aminopropyltrimethoxysilane (reaction products with silica and chlorosulfonic acid) ;  60 min, 80 °C

Reference

Preparation of different amides via Ritter reaction from alcohols and nitriles in the presence of silica-bonded N-propylsulphamic acid (SBNPSA) under solvent-free conditions

Shakeri, Maryam-Sadat; Tajik, Hassan; Niknam, Khodabakhsh, Journal of Chemical Sciences (Bangalore, 2012, 124(5), 1025-1032

Production Method 8

873-75-6

90561-76-5

Reaction Conditions

1.1 Catalysts: Calcium bisulfate Solvents: Acetonitrile ;  2.0 h, 80 °C

Reference

Ca(HSO4)2 mediated conversion of alcohols into N-substituted amides under heterogeneous conditions: a modified Ritter reaction

Niknam, K.; Zolfigol, M. A.; Sadabadi, T., Journal of the Iranian Chemical Society, 2007, 4(2), 199-204

Production Method 9

90561-76-5

Reaction Conditions

1.1 Reagents: Water Catalysts: 4-tert-Butylbenzoic acid ,  Iodobenzene ,  Boron trifluoride ,  Selectfluor Solvents: Acetonitrile ;  16 h, 25 °C

Reference

C(sp3)-H Ritter amination by excitation of in-situ generated iodine(III)-BF3 complexes

Narobe, Rok; Murugesan, Kathiravan; Haag, Christoph; Schirmer, Tobias Emanuel; Koenig, Burkhard, Chemical Communications (Cambridge, 2022, 58(63), 8778-8781

Production Method 10

3959-07-7

90561-76-5

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  5 min, 0 °C
1.2 5 h, 0 °C → rt

Reference

Distal meta-alkenylation of formal amines enabled by catalytic use of hydrogen-bonding anionic ligands

Goswami, Nupur; Sinha, Soumya Kumar; Mondal, Partha; Adhya, S.; Datta, Ayan; et al, Chem, 2023, 9(4), 989-1003

Production Method 11

90561-76-5

Reaction Conditions

1.1 Reagents: Tetraethylammonium tetrafluoroborate ,  Potassium bromide Solvents: Dichloromethane ,  Water ;  2 h

Reference

Amino acids in electrochemical metal-free benzylic C-H amidation

Strekalova, Sofia ; Kononov, Alexander; Budnikova, Yulia, Tetrahedron Letters, 2022, 102,

Production Method 12

1878-68-8

90561-76-5

Reaction Conditions

1.1 Reagents: Boron trifluoride ,  Water ,  Selectfluor Catalysts: Iodobenzene Solvents: Acetonitrile ;  16 h, 25 °C

Reference

Decarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)-Boron Lewis Acid Catalysis

Narobe, Rok; Murugesan, Kathiravan; Schmid, Simon; Koenig, Burkhard, ACS Catalysis, 2022, 12(1), 809-817

Production Method 13

90561-76-5

74315-07-4

337535-82-7

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-bromo-, sodium salt (1:1) Solvents: Water ;  2.5 h, 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  basified
1.3 Reagents: Pyridine ;  2 h, rt
1.4 Reagents: Water

Reference

Chemistry of unprotected amino acids in aqueous solution: direct bromination of aromatic amino acids with bromoisocyanuric acid sodium salt under strong acidic condition

Yokoyama, Yuusaku; Yamaguchi, Tomotsugu; Sato, Masanori; Kobayashi, Eri; Murakami, Yasuoki; et al, Chemical & Pharmaceutical Bulletin, 2006, 54(12), 1715-1719

N-(4-Bromophenyl)methylacetamide Raw materials

• 4-Bromobenzyl alcohol
• 4-Bromobenzylamine
• 2-(4-bromophenyl)acetic acid
• 1-(azidomethyl)-4-bromobenzene

N-(4-Bromophenyl)methylacetamide Preparation Products

• N-(2-Bromobenzyl)acetamide (74315-07-4)
• N-(4-Bromophenyl)methylacetamide (90561-76-5)
• N-(3-Bromobenzyl)acetamide (337535-82-7)

• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 2. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 3. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Bromobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Bromobenzenes

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• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)