Production Method 1

24424-99-5

90365-74-5

90481-33-7

Reaction Conditions

1.1 Reagents: Ammonium formate Catalysts: Palladium dihydroxide Solvents: Methanol ;  3 h, reflux

Reference

Low-generation dendrimers with a calixarene core and based on a chiral C2-symmetric pyrrolidine as imino sugar mimics

Marradi, Marco; Cicchi, Stefano; Sansone, Francesco; Casnati, Alessandro; Goti, Andrea, Beilstein Journal of Organic Chemistry, 2012, 8, 951-957

Production Method 2

24424-99-5

136779-52-7

90481-33-7

Reaction Conditions

Reference

Asymmetric hydrogenation of α-(acetylamino)cinnamic acids with a new rhodium complex; the concept of an optimal ligand

Nagel, Ulrich, Angewandte Chemie, 1984, 96(6), 425-6

Production Method 3

24424-99-5

90481-32-6

90481-33-7

Reaction Conditions

1.1 Reagents: Acetic acid ,  Potassium carbonate Solvents: Methanol ,  Chloroform

Reference

Asymmetric Addition of Diethylzinc to Ketones promoted by Tartaric Acid Derivatives

Hui, Ailing; Zhang, Jintang; Wang, Zhiyong, Synthetic Communications, 2008, 38(14), 2374-2384

Production Method 4

24424-99-5

90365-74-5

90481-33-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  20 h, rt

Reference

Selective Isomerization via Transient Thermodynamic Control: Dynamic Epimerization of trans to cis Diols

Oswood, Christian J.; MacMillan, David W. C., Journal of the American Chemical Society, 2022, 144(1), 93-98

Production Method 5

24424-99-5

163439-82-5

90481-33-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  20 h, 1 atm, rt

Reference

Synthesis of iminodiacetaldehyde derivatives as building blocks for pharmacologically active agents

Fricke, Yvonne; Kopp, Nicole; Wuensch, Bernhard, Synthesis, 2010, (5), 791-796

Production Method 6

114214-49-2

90481-33-7

Reaction Conditions

1.1 Reagents: Water Catalysts: stereoisomer of [μ-[(4aR,27aR,31aR,54aR)-9,23,36,50-Tetrakis(1,1-dimethylethyl)-… Solvents: Acetonitrile ;  24 h, 23 °C
1.2 Reagents: Pyridinium p-toluenesulfonate ;  23 °C

Reference

A broadly applicable and practical oligomeric (salen)Co catalyst for enantioselective epoxide ring-opening reactions

White, David E.; Tadross, Pamela M.; Lu, Zhe; Jacobsen, Eric N., Tetrahedron, 2014, 70(27-28), 4165-4180

Production Method 7

24424-99-5

926912-80-3

90481-33-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  2 h, rt

Reference

Synthesis of diastereomeric 3-hydroxy-4-pyrrolidinyl derivatives of nucleobases

Rejman, Dominik; Kocalka, Petr; Budesinsky, Milos; Pohl, Radek; Rosenberg, Ivan, Tetrahedron, 2007, 63(5), 1243-1253

Production Method 8

24424-99-5

90481-32-6

90481-33-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ,  Chloroform ;  overnight, rt

Reference

Chiral pyrrolidine thioethers: effective nitrogen-sulfur donating ligands in palladium-catalyzed asymmetric allylic alkylations

Siedlecka, Renata; Wojaczynska, Elzbieta; Skarzewski, Jacek, Tetrahedron: Asymmetry, 2004, 15(9), 1437-1444

tert-butyl (3S,4S)-3,4-dihydroxypyrrolidine-1-carboxylate Raw materials

• Di-tert-butyl dicarbonate
• (3S,4S)-1-Benzylpyrrolidine-3,4-diol
• (3S,4S)-Pyrrolidine-3,4-diol
• Tert-butyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate
• trans-pyrrolidine-3,4-diol
• 3-Pyrrolidinol, 4-[bis(4-methoxyphenyl)phenylmethoxy]-1-(phenylmethyl)-, 3-methanesulfonate, (3R,4R)-
• (3R,4R)-1-Benzylpyrrolidine-3,4-diol

tert-butyl (3S,4S)-3,4-dihydroxypyrrolidine-1-carboxylate Preparation Products

• tert-butyl (3S,4S)-3,4-dihydroxypyrrolidine-1-carboxylate (90481-33-7)

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• 109431-87-0((R)-(-)-N-Boc-3-pyrrolidinol)
• 101469-92-5((S)-1-N-Boc-3-hydroxypyrrolidine)
• 276862-86-3(1-Pyrrolidinecarboxylic acid, 3,4-dimethoxy-, 1,1-dimethylethyl ester,(3S,4S)-)
• 146257-03-6(1-Pyrrolidinecarboxylicacid, 3-methoxy-, 1,1-dimethylethyl ester)
• 298681-10-4(tert-Butyl 3,4-dihydroxypyrrolidine-1-carboxylate)
• 412278-02-5(tert-butyl 3-hydroxy-3-methyl-pyrrolidine-1-carboxylate)
• 849924-42-1(Tert-butyl (3S,4S)-3,4-dihydroxypyrrolidine-1-carboxylate)
• 83220-73-9(1-Boc-(R)-(-)-3-Hydroxypyrrolidine)
• 103057-44-9(tert-Butyl 3-hydroxypyrrolidine-1-carboxylate)
• 186393-22-6(tert-butyl cis-3,4-dihydroxypyrrolidine-1-carboxylate)