Cas no 103057-44-9 (tert-Butyl 3-hydroxypyrrolidine-1-carboxylate)
tert-Butyl 3-hydroxypyrrolidine-1-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- tert-Butyl 3-hydroxypyrrolidine-1-carboxylate
- 3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1-BOC-3-HYDROXYPYRROLIDINE
- 1-N-BOC-3-HYDROXY-PYRROLIDINE
- N-BOC-3-HYDROXYPYRROLIDINE
- N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
- (S) 1-BOC-3-hydroxylpyrrolidine
- 3-Hydroxypyrrolidine, N-BOC protected
- (±)-1-Boc-3-hydroxypyrrolidine
- 1-Boc-3-pyrrolidinol
- 1-(tert-Butoxycarbonyl)-3-pyrrolidinol
- (R)-1-Boc-3-hydroxypyrrolidine
- (R)-1-N-BOC-3-HYDROXYPYRROLIDINE
- (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
- 1-N-Boc-3-hydroxypyrrolidine
- 1-tert-Butoxycarbonyl-3-hydroxypyrrolidine
- 1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
- N-Boc-3-pyrrolidinol
- (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
- (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
- 1-Boc-3-hydropyrrolidine
- -BOC-3-HYDROXYPYRROLIDINE
- 1-Boc-3-hydroxypyrrolidin...
- Zinc00403504
- 1-Boc-3-pyrrolidinol 95%
- 1-Boc-3-pyrrolidinol, >=97%
- MFCD04038535
- dl-1-boc-3-hydroxy-pyrrolidine
- N-tert-butoxycarbonyl-3-hydroxy-pyrrolidine
- tert-butyl 3-hydroxypyrrolidinecarboxylate
- APCBTRDHCDOPNY-UHFFFAOYSA-N
- 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine
- t-Butyl 3-Hydroxy-1-pyrrolidine-carboxylate
- tert-butyl 3-oxidanylpyrrolidine-1-carboxylate
- 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester
- SCHEMBL241055
- 1-t-butoxycarbonyl-3hydroxypyrrolidine
- (RS) 1-tert-butoxycarbonyl-3-pyrrolidinol
- (RS)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
- SY002350
- B3603
- 3-hydroxy-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
- BCP01704
- 103057-44-9
- t-butyl 3-hydroxypyrrolidine-1-carboxylate
- 1-tert.butoxycarbonyl-3-hydroxy-pyrrolidine
- tert-butyl-3-hydroxy-1-pyrrolidinecarboxylate
- 1-BOC-(R)-(-)-3-HYDROXYPYRROLIDINE
- tert.butyl-3-hydroxy-1-pyrrolidinecarboxylate
- F0001-0083
- 3-Hydroxy-pyrrolidine-1-carboxylic acid tert butyl ester
- N-tert-butoxycarbonylpyrrolidin-3-ol
- (r/s)-1-tert-butoxycarbonyl-3-hydroxypyrrolidine
- 3-hydroxy-pyrrolidine-1-carboxylic acid t-butyl ester
- AC-6706
- FT-0630176
- EN300-61934
- tert-Butyl3-hydroxypyrrolidine-1-carboxylate
- NS00015502
- tert-butyl 3-hydroxy-1-pyrrolidinecarboxylate
- rac-tert-butyl 3-hydroxy-1-pyrrolidinecarboxylate
- N-BOC-3-pyrrolodinol
- AKOS005257151
- CS-W003140
- 3-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester
- SB10190
- N-BENZYL-N-(1,1-DIOXIDO-2,3-DIHYDROTHIEN-3-YL)AMINEHYDROCHLORIDE
- FT-0601113
- PB18546
- Z975914016
- A800391
- FT-0601114
- DTXSID90403046
- PB44607
- t-butyl 3-hydroxy-1-pyrrolidinecarboxylate
- 1-Boc-3-pyrrolidinol, 95%
- 1-t-butoxycarbonyl-3-hydroxypyrrolidine
- PS-3870
- tert-butyl-3-hydroxypyrrolidine-1-carboxylate
- SB10191
- SY001204
- t-butyl 3-hydroxypyrrolidin-1-carboxylate
- HY-W003140
- (+/-)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
- N-(tert-butoxy-carbonyl)-3-hydroxypyrrolidine
- 1-tert-Butyloxycarbonyl-3-hydroxypyrrolidine
- 83220-73-9
- 1-(tert-butoxycarbonyl)-3-hydroxy-pyrrolidine
- 3-Hydroxypyrrolidine-1-carboxylic acid tert-butyl ester
- 1,1-dimethylethyl 3-hydroxypyrrolidine-1-carboxylate
- (S)-(+)-1-Boc-3-hydroxypyrrolidine
- ALBB-016818
- SY001993
- (R)-(-)-N-Boc-3-pyrrolidinol;(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
- STL134748
- DB-363779
- 1-Boc-(R)-3-Hydroxypyrrolidine
-
- MDL： MFCD01317838
- Inchi： 1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3
- InChI Key： APCBTRDHCDOPNY-UHFFFAOYSA-N
- SMILES： O(C(N1CCC(C1)O)=O)C(C)(C)C
Computed Properties
- Exact Mass: 187.12100
- Monoisotopic Mass: 187.121
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 13
- Rotatable Bond Count: 3
- Complexity: 198
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 0.6
- Topological Polar Surface Area: 49.8A^2
Experimental Properties
- Color/Form: White to Yellow Solid
- Density: 1.142
- Melting Point: 57-63?°C
- Boiling Point: 273.3±33.0°C at 760 mmHg
- Flash Point: 119.1℃
- Refractive Index: 1.502
- PSA: 49.77000
- LogP: 0.92600
- Solubility: Not determined
tert-Butyl 3-hydroxypyrrolidine-1-carboxylate Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Danger
- Hazard Statement： H301,H315,H319,H335
- Warning Statement： P261,P301+P310,P305+P351+P338
- Hazardous Material transportation number：UN 3077 9 / PGIII
- WGK Germany：2
- Hazard Category Code： 25-36/37/38
- Safety Instruction： S26
-
Hazardous Material Identification：
- Safety Term：S26-36/37/39-37
- Risk Phrases：R36/37/38
- HazardClass：6.1
- PackingGroup：Ⅲ
- Storage Condition：2-8°C
tert-Butyl 3-hydroxypyrrolidine-1-carboxylate Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
tert-Butyl 3-hydroxypyrrolidine-1-carboxylate Pricemore >>
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tert-Butyl 3-hydroxypyrrolidine-1-carboxylate |
103057-44-9 | 98% | 5g |
￥46.90 | 2023-09-04 |
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tert-Butyl 3-hydroxypyrrolidine-1-carboxylate Related Literature
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Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
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Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
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Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
Additional information on tert-Butyl 3-hydroxypyrrolidine-1-carboxylate
tert-Butyl 3-Hydroxypyrrolidine-1-Carboxylate: A Comprehensive Overview
tert-Butyl 3-Hydroxypyrrolidine-1-Carboxylate (CAS No. 103057-44-9) is a versatile compound with significant applications in various fields of organic chemistry and materials science. This compound, often referred to as TBHPyC for brevity, has garnered attention due to its unique structural properties and functional groups. The molecule consists of a pyrrolidine ring, a hydroxyl group, and a tert-butyl ester moiety, making it a valuable intermediate in the synthesis of complex molecules.
Recent studies have highlighted the potential of tert-butyl 3-hydroxypyrrolidine-1-carboxylate in drug delivery systems. Researchers have explored its ability to act as a carrier for hydrophobic drugs, leveraging its amphiphilic nature to enhance solubility and bioavailability. This application is particularly promising in the development of targeted therapies, where precise drug delivery is critical.
The synthesis of tert-butyl 3-hydroxypyrrolidine-1-carboxylate involves a multi-step process that typically begins with the preparation of pyrrolidine derivatives. Recent advancements in catalytic asymmetric synthesis have enabled the production of enantiomerically pure forms of this compound, which are essential for pharmaceutical applications. The use of transition metal catalysts has significantly improved the yield and selectivity of these reactions.
Another area where tert-butyl 3-hydroxypyrrolidine-1-carboxylate has shown promise is in polymer chemistry. Its ability to undergo ring-opening polymerization under specific conditions has led to the development of novel polyamides and polyesters with tailored mechanical properties. These materials are being investigated for use in biodegradable packaging and biomedical devices.
In terms of physical properties, tert-butyl 3-hydroxypyrrolidine-1-carboxylate exhibits a melting point of approximately 65°C and is soluble in common organic solvents such as dichloromethane and ethyl acetate. Its hydroxyl group imparts moderate polarity, while the tert-butyl ester contributes to its stability under thermal conditions.
Recent research has also focused on the catalytic applications of tert-butyl 3-hydroxypyrrolidine-1-carboxylate. As a ligand in transition metal complexes, it has been shown to enhance the activity and selectivity of catalysts in olefin polymerization and hydrogenation reactions. This finding underscores its potential as a valuable tool in industrial catalysis.
Furthermore, the compound's role in asymmetric induction has been explored extensively. Its chiral center provides an excellent platform for enantioselective synthesis, making it a valuable asset in the production of chiral pharmaceuticals and agrochemicals.
In conclusion, tert-butyl 3-hydroxypyrrolidine-1-carboxylate (CAS No. 103057-44-9) is a multifaceted compound with diverse applications across various disciplines. Its unique structure, coupled with recent advancements in synthetic methodologies and catalytic applications, positions it as a key player in modern chemical research.
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