Production Method 1

767-00-0

1885-46-7

90446-25-6

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ,  Water ;  2 min, rt

Reference

Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

Fier, Patrick S.; Hartwig, John F., Angewandte Chemie, 2013, 52(7), 2092-2095

Production Method 2

767-00-0

17378-82-4

44498-05-7

90446-25-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ;  4 h, 75 °C

Reference

Decarboxylative Trifluoromethylating Reagent [Cu(O2CCF3)(phen)] and Difluorocarbene Precursor [Cu(phen)2][O2CCF2Cl]

Lin, Xiaoxi; Hou, Chuanqi; Li, Haohong; Weng, Zhiqiang, Chemistry - A European Journal, 2016, 22(6), 2075-2084

Production Method 3

767-00-0

90446-25-6

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Water ;  30 min, rt
1.2 Solvents: Acetonitrile ;  2 h, rt; 1 h, rt
1.3 Reagents: Water

Reference

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes

Thomoson, Charles S.; Dolbier, William R., Journal of Organic Chemistry, 2013, 78(17), 8904-8908

Production Method 4

767-00-0

90446-25-6

Reaction Conditions

Reference

Chlorodifluoromethane

Burton, Donald J.; Qiu, Weiming; Joneczyk, Andrzej; Kowalkowska, Anna, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2010, 1, 1-6

Production Method 5

767-00-0

90446-25-6

Reaction Conditions

1.1 Reagents: Benzyltriethylammonium chloride ,  Sodium hydroxide ,  Benzyltriethylammonium hydroxide Solvents: Hexane ,  Water

Reference

Method of preparing alcohol or phenol difluoromethyl ethers

, USSR, , ,

Production Method 6

354-08-5

767-00-0

90446-25-6

Reaction Conditions

1.1 Reagents: Cesium carbonate Catalysts: fac-Tris(2-(2-pyridinyl)phenyl)iridium Solvents: Dimethylformamide ;  9 h, 25 °C

Reference

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid

Yang, Jinyan; Jiang, Min; Jin, Yunhe; Yang, Haijun; Fu, Hua, Organic Letters, 2017, 19(10), 2758-2761

Production Method 7

767-00-0

1449521-05-4

90446-25-6

Reaction Conditions

1.1 Solvents: p-Xylene ;  2 h, 90 °C

Reference

Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation

Deng, Xiao-Yun; Lin, Jin-Hong; Zheng, Jian; Xiao, Ji-Chang, Chemical Communications (Cambridge, 2015, 51(42), 8805-8808

Production Method 8

73152-40-6

90446-25-6

Reaction Conditions

1.1 Reagents: Phosphorus pentachloride Solvents: Dichloromethane ;  12 h, 35 °C
1.2 Reagents: Hydrofluoric acid Solvents: Tetrahydrofuran ;  12 h, rt
1.3 Solvents: Water ;  rt

Reference

Three step procedure for the preparation of aromatic and aliphatic difluoromethyl ethers from phenols and alcohols using a chlorine/fluorine exchange methodology

Dolbier, William R. Jr.; Wang, Fei; Tang, Xiaojun; Thomoson, Charles S.; Wang, Linhua, Journal of Fluorine Chemistry, 2014, 160, 72-76

4-(Difluoromethoxy)benzonitrile Raw materials

• Bromodifluoroacetic acid
• 4-Hydroxybenzonitrile
• Copper(1+),bis(1,10-phenanthroline-kN1,kN10)-, (T-4)-
• Acetic acid, 2-chloro-2,2-difluoro-, ion(1-)
• 5-Methylpyrimidin-2-amine
• Benzonitrile, 4-(formyloxy)-
• 2,2-difluoro-2-triphenylphosphaniumylacetate

4-(Difluoromethoxy)benzonitrile Preparation Products

• 4-(Difluoromethoxy)benzonitrile (90446-25-6)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers
• Pharmaceutical and Biochemical Products Medicinal Building Blocks Fluorine containing Building Blocks
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

• 56935-78-5(2-(Difluoromethoxy)benzonitrile)
• 867281-14-9(Benzonitrile, 4-(fluoromethoxy)-)
• 97582-88-2(3-(Difluoromethoxy)benzonitrile)
• 157788-40-4(4-4-(Trifluoromethoxy)phenylbenzonitrile)
• 867366-83-4(BENZONITRILE, 3-(DIFLUOROMETHOXY)-5-HYDROXY-)
• 332-25-2(4-(Trifluoromethoxy)benzonitrile)
• 832737-32-3(4-(Difluoromethoxy)-3-methoxybenzonitrile)
• 52771-22-9(3-(Trifluoromethoxy)benzonitrile)
• 1334721-50-4(3-4-(Trifluoromethoxy)phenylbenzonitrile)
• 1261823-17-9(4-(Difluoromethoxy)-3-Hydroxybenzonitrile)