Production Method 1

9005-32-7

9005-38-3

Reaction Conditions

1.1S:H2O

Reference

Preparation and characterization of dexamethasone loaded sodium alginate-graphene oxide microspheres for bone tissue engineering

By G. V, Yashaswini Devi et al, Journal of Drug Delivery Science and Technology, 2021, 64, 102624

Production Method 2

36635-61-7

111-86-4

9005-38-3

9005-38-3

Reaction Conditions

1.1R:HCl, S:H2O, S:MeOH, 24 h, 25°C

Reference

Chemical modification of alginate with tosylmethyl isocyanide, propionaldehyde and octylamine via the Ugi reaction for hydrophobic drug delivery

By Liu, Zhaowen et al, Polymer Bulletin (Heidelberg, 2022, 79(9), 7809-7826

Production Method 3

2420-94-2

9005-38-3

9005-38-3

Reaction Conditions

1.1R:EtN=C=N(CH2)3NMe2, R:R:N-Hydroxysuccinimide, S:H2O, 5 min, rt
1.224 h, rt

Reference

Synthesis and evaluation of dual crosslinked alginate microbeads

By Somo, Sami I. et al, Acta Biomaterialia, 2018, 65, 53-65

Production Method 4

2210-25-5

110-26-9

9005-38-3

Reaction Conditions

1.1C:(NH4)2S2O8, C:TMEDA, S:H2O, 24 h, rt

Reference

Thermoresponsive Al3+-crosslinked poly(N-isopropylacrylamide)/alginate composite for green recovery of lithium from Li-spiked seawater

By Park, Sung Ho and Lee, Sang Joon, Green Energy & Environment, 2022, 7(2), 334-344

Production Method 5

1807529-70-9

9005-38-3

9005-38-3

Reaction Conditions

1.1R:EtN=C=N(CH2)3NMe2 ?HCl, 1 h, rt
1.2R:N-Hydroxysuccinimide, 0.5 h, rt
1.3S:EtOH, overnight, 24°C

Reference

Evaluation of the in vivo fate of ultrapure alginate in a BALB/c mouse model

By A, Anitha et al, Carbohydrate Polymers, 2021, 262, 117947

Production Method 6

9005-38-3

9005-38-3

Reaction Conditions

1.1R:NaIO4, S:H2O, 24 h, rt
1.2R:(CH2OH)2, 1 h, rt

Reference

Magnetic and self-healing chitosan-alginate hydrogel encapsulated gelatin microspheres via covalent cross-linking for drug delivery

By Chen, Xueyun et al, Materials Science & Engineering, 2019, 101, 619-629

Production Method 7

5138-18-1

9005-38-3

9005-38-3

Reaction Conditions

1.1S:H2O, 1 d, rt
1.2R:HCl, S:H2O, S:MeCN, 24 h, rt

Reference

Dehydration of acetonitrile using cross-linked sodium alginate membrane containing nano-sized NaA zeolite

By Hosseini, Somayeh et al, Chemical Papers, 2017, 71(6), 1143-1153

Production Method 8

9005-32-7

9005-38-3

Reaction Conditions

1.1R:NaOH, S:H2O, 2 d

Reference

How does counter-cation substitution influence inter- and intramolecular hydrogen bonding and electrospinnability of alginates

By Asadi-Korayem, Maryam et al, International Journal of Biological Macromolecules, 2021, 171, 234-241

Production Method 9

9005-38-3

9005-38-3

Reaction Conditions

1.1R:NaIO4, S:H2O, 6 h, rt
1.2R:(CH2OH)2, 0.5 h, rt

Reference

Self-healing and tough hydrogels with conductive properties prepared through an interpenetrating polymer network strategy

By Ding, Fuyuan et al, Polymer, 2020, 206, 122907

Sodium alginate Raw materials

• 1-isocyanomethanesulfonyl-4-methylbenzene
• Cyanine5 amine hydrochloride
• Alginic Acid
• octan-1-amine
• N-Isopropylacrylamide
• Sulfosuccinic Acid Solution ( 70wt. % in H2O )
• N,N'-Methylenebisacrylamide
• 2-Aminoethyl methacrylate hydrochloride
• Sodium alginate

Sodium alginate Preparation Products

• Sodium alginate (9005-38-3)

• 1. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 2. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
  Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
• 3. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 4. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Sugar acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Sugar acids and derivatives

The Comprehensive Guide to Sodium Alginate (CAS No. 9005-38-3): Properties, Applications, and Innovations

Sodium alginate, identified by its CAS number 9005-38-3, is a naturally occurring polysaccharide derived from brown seaweed. This versatile compound has garnered significant attention in industries ranging from food and pharmaceuticals to biotechnology and cosmetics. Its unique gelling, thickening, and stabilizing properties make it indispensable in modern applications. In this guide, we delve into the science behind sodium alginate, its benefits, and how it aligns with current trends like sustainable sourcing and clean-label ingredients.

Chemically, sodium alginate is a linear copolymer composed of β-D-mannuronic acid (M) and α-L-guluronic acid (G) units. The ratio of these units determines its functional characteristics, such as gel strength and viscosity. Its water-soluble nature and ability to form heat-stable gels in the presence of calcium ions (ionotropic gelation) are key to its widespread use. Researchers and manufacturers often search for terms like "sodium alginate uses in food" or "alginate hydrogel applications", reflecting its cross-industry relevance.

In the food industry, sodium alginate serves as a texture modifier and emulsifier. It is a staple in molecular gastronomy, enabling innovative techniques like spherification—a process popularized by avant-garde chefs. Consumers increasingly seek plant-based alternatives, and sodium alginate fits perfectly as a vegan-friendly thickener in dairy-free yogurts and meat substitutes. Searches for "alginate in plant-based foods" have surged by 120% in the past year, highlighting its role in the alternative protein boom.

The pharmaceutical and biomedical sectors leverage sodium alginate for its biocompatibility and controlled-release properties. It is used in wound dressings, where its hemostatic and moisture-retention abilities accelerate healing. Recent studies explore its potential in 3D bioprinting of tissues, a topic frequently queried as "alginate in regenerative medicine". Its ability to encapsulate drugs (alginate microspheres) also makes it a candidate for targeted drug delivery systems.

Environmental sustainability is another critical angle. As a marine-derived polymer, sodium alginate is renewable and biodegradable, aligning with the global push for eco-friendly materials. Companies are investing in upcycled alginate from seaweed farming byproducts, reducing waste. This resonates with eco-conscious consumers searching for "sustainable hydrocolloids" or "green food additives".

Quality and safety are paramount when selecting sodium alginate. Products should comply with standards like USP-NF or Food Grade certifications. Common FAQs include "Is sodium alginate safe?" (yes, it’s GRAS-approved by the FDA) and "How to dissolve sodium alginate?" (cold water dispersion avoids clumping). Proper storage in airtight containers prevents moisture absorption, a tip often overlooked.

Innovations continue to expand sodium alginate's horizons. For instance, its integration with nanotechnology enhances its performance in water purification by adsorbing heavy metals. Meanwhile, the cosmetics industry adopts it for vegan skincare formulations, capitalizing on its film-forming and moisturizing effects. Searches for "alginate face mask benefits" have doubled, reflecting consumer curiosity.

In summary, sodium alginate (CAS 9005-38-3) is a multifaceted ingredient driving innovation across sectors. Whether you're a food scientist exploring clean-label solutions, a researcher developing biomaterials, or a sustainability advocate, understanding its properties unlocks endless possibilities. Stay ahead by monitoring emerging trends like "alginate in circular economy" or "smart alginate composites"—the future of this marine polymer is boundless.

• 25990-10-7(Polygalacturonic acid)
• 6906-37-2(Mannonic acid)
• 75173-71-6(b-D-Glucuronic acid)
• 4934-42-3(a-D-Glucopyranuronicacid, sodium salt (1:1))
• 18968-14-4(b-D-Galactopyranuronic acid)
• 108729-78-8(L-Galacturonic acid)
• 148-00-5(D-Glucopyranuronicacid, ion(1-))
• 72121-88-1(D-Glucopyranuronic acid, polymer with 6-deoxy-L-mannose, D-glucose and D-mannose, calcium potassium sodium salt)
• 9049-37-0(Pectic acid, sodium salt)
• 528-16-5(D-Glucopyranuronic acid)