Production Method 1

90-60-8

Reaction Conditions

1.1 Reagents: Sodium sulfate Solvents: Dichloromethane ;  overnight, rt

Reference

Synthesis of new Schiff base-camphorsulfonyl amide ligands and in situ screening in the asymmetric additions of organozinc reagents to aldehydes

Sun, Jiangtao; Pan, Xu; Dai, Zhenya; Zhu, Chengjian, Tetrahedron: Asymmetry, 2008, 19(21), 2451-2457

Production Method 2

50848-92-5

90-60-8

Reaction Conditions

1.1 Reagents: Manganese oxide (MnO2)

Reference

Oxidation of hydrazides of salicylic and substituted salicylic acids with active manganese dioxide

Haksar, C. N.; Malhotra, R. C.; Ramachandran, P. K., Indian Journal of Chemistry, 1979, (2), 191-3

Production Method 3

90-02-8

90-60-8

Reaction Conditions

1.1 Reagents: Chlorosuccinimide ;  6 h, 25 - 30 °C

Reference

Simple way to synthesize halogenated salicyladehydes

Li, Feng; Sun, Lian-jie; Gao, Wen-tao, Bohai Daxue Xuebao, 2012, 33(1), 32-36

Production Method 4

90-60-8

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Tetrahydrofuran ;  15 min
1.2 4 h, reflux

Reference

Bayesian-optimization-assisted discovery of stereoselective aluminum complexes for ring-opening polymerization of racemic lactide

Wang, Xiaoqian ; Huang, Yang; Xie, Xiaoyu; Liu, Yan; Huo, Ziyu; et al, Nature Communications, 2023, 14(1),

Production Method 5

90-60-8

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Acetonitrile ,  Dichloromethane ;  rt; 12 h, 125 °C; 125 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Highly-selective synthesis of functionalized spirobenzofuranones and diketones

Chen, Yin-Jun; Xu, Hui-Bei; Liu, Hao; Dong, Lin, Organic Chemistry Frontiers, 2022, 9(17), 4633-4639

Production Method 6

90-02-8

90-60-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid ,  Sodium chloride ,  Sodium hypochlorite

Reference

Halogenation of benzene derivatives with electron-acceptor substituents under conditions generating electrophilic chlorine and bromine

Sadiqov, O. A., Kimya Problemlari, 2009, (4), 676-679

Production Method 7

6641-02-7

90-60-8

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Tempo ,  2978140-34-8 Solvents: Water ;  10 h, 40 °C

Reference

Selective aerobic oxidation of biomass model compound veratryl alcohol catalyzed by air-stable copper(II) complexes in water

Jana, Narayan Ch.; Behera, Sourav; Maharana, Suraj Kumar; Behera, Rakesh R.; Bagh, Bidraha, Catalysis Science & Technology, 2023, 13(18), 5422-5434

Production Method 8

90-02-8

90-60-8

Reaction Conditions

1.1 Reagents: 1,3-Dichloro-5,5-dimethylhydantoin Solvents: Ethanol ;  5 h, reflux

Reference

Synthesis and fungicidal activities of 4-(tert-butyl)-5-benzyl-2-(benzylimino)thiazoles

Yang, Lin-tao; Qin, Zhi; Chen, Ping; Hu, Ai-xi, Yingyong Huaxue, 2010, 27(6), 664-668

Production Method 9

90-60-8

Reaction Conditions

1.1 Reagents: Hexamethylenetetramine Solvents: Acetic acid ;  3 h, reflux; reflux → rt
1.2 Reagents: Sulfuric acid Solvents: Water ;  30 min, reflux

Reference

Structural characterization of new Schiff bases of sulfamethoxazole and sulfathiazole, their antibacterial activity and docking computation with DHPS protein structure

Mondal, Sudipa; Mandal, Santi M.; Mondal, Tapan Kumar; Sinha, Chittaranjan, Spectrochimica Acta, 2015, 150, 268-279

Production Method 10

90-60-8

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ;  20 h, rt → 115 °C; 115 °C → 60 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  60 °C → 130 °C; 1 h, 130 °C; cooled
1.3 Reagents: Sodium bicarbonate ;  pH 6 - 7

Reference

Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands

Li, Li-Jun; Yan, Qin-Qin; Liu, Guo-Jun; Yuan, Zhen; Lv, Zhen-Hua; et al, Bioscience, 2017, 81(6), 1081-1089

Production Method 11

90-60-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  1.75 h, 65 - 70 °C; 3 h, 20 - 25 °C

Reference

An improved procedure for the synthesis of substituted o-hydroxybenzaldehydes by modified operation in the Reimer-Tiemann reaction

Vibhute, Yeshwant B.; Lonkar, Subhash M.; Mokle, Shyam S.; Sayyed, Mudassar A., Chemistry: An Indian Journal, 2006, 3(6-7), 209-211

Production Method 12

90-60-8

Reaction Conditions

Reference

Formylation of phenols with electron-withdrawing groups in strong acids. Synthesis of substituted salicylaldehydes

Suzuki, Yuji; Takahashi, Hiroshi, Chemical & Pharmaceutical Bulletin, 1983, 31(5), 1751-3

Production Method 13

90-60-8

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Acetonitrile ;  80 °C

Reference

Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-b]pyrroles

Li, Xiaohu; Huang, You, Chemical Communications (Cambridge, 2021, 57(77), 9934-9937

Production Method 14

90-60-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  15 min, 65 °C; 2 h, reflux; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified

Reference

Cytotoxicity of new pyridazin-3(2H)-one derivatives orchestrating oxidative stress in human triple-negative breast cancer (MDA-MB-468)

Bouchmaa, Najat ; Ben Mrid, Reda; Boukharsa, Youness; Nhiri, Mohamed; Ait Mouse, Hassan; et al, Archiv der Pharmazie (Weinheim, 2018, 351(12),

3,5-Dichlorosalicylaldehyde Raw materials

• Benzoic acid, 3,5-dichloro-2-hydroxy-, hydrazide
• 2-Hydroxybenzaldehyde
• 2,4-Dichloro-6-(hydroxymethyl)phenol

3,5-Dichlorosalicylaldehyde Preparation Products

• 3,5-Dichlorosalicylaldehyde (90-60-8)

• 1. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 2. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 3. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960
• 4. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 5. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Aldehydes
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 27164-09-6(3,6-dichloro-2-hydroxybenzaldehyde)
• 32596-43-3(5-Chloro-2-hydroxyisophthalaldehyde)
• 49860-79-9(Cobalt,bis(3,5-dichloro-2-hydroxybenzaldehydato-O,O')- (9CI))
• 23602-63-3(5-Chloro-2-hydroxy-3-methylbenzaldehyde)
• 635-93-8(5-Chlorosalicylaldehyde)
• 1927-94-2(3-Chloro-2-hydroxybenzaldehyde)
• 2420-16-8(3-Chloro-4-hydroxybenzaldehyde)
• 2420-26-0(4-Chloro-2-hydroxybenzaldehyde)
• 1570-65-6(2,4-Dichloro-6-methylphenol)
• 2314-36-5(3,5-Dichloro-4-hydroxybenzaldehyde)