- Synthesis, characterization and anti-inflammatory activity of novel pyrazolyl ketoamidesMahaveer, P.; Kulkarni, R. G.; Radakrishna, P.; Chandrashekar, V. M.; Achaiah, G., Indian Journal of Chemistry, 2013, (6), 818-823
Cas no 898537-77-4 (3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine)
898537-77-4 structure
Product Name:3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine
CAS No:898537-77-4
MF:C14H19N3
MW:229.320762872696
MDL:MFCD04115069
CID:715090
PubChem ID:7016491
Update Time:2024-10-26
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Chemical and Physical Properties
Names and Identifiers
-
- 3-(tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine
- 1H-Pyrazol-5-amine,3-(1,1-dimethylethyl)-1-(3-methylphenyl)-
- 3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-amine
- 5-tert-butyl-2-(3-methylphenyl)pyrazol-3-amine
- 5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-ylamine
- YDYDGSYHOOCUPO-UHFFFAOYSA-N
- 4897AC
- AB19565
- AK114134
- ST24041672
- Z228589382
- 3-(1,1-Dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5-a
- 3-(1,1-Dimethylethyl)-1-(3-methylphenyl)-1H-pyrazol-5-amine (ACI)
- 3-tert-Butyl-1-(m-tolyl)-1H-pyrazol-5-amine
- CS-0142923
- DB-078529
- Y10413
- MFCD04115069
- DTXSID10426853
- 898537-77-4
- AKOS009113513
- AC-29601
- 3-TERT-BUTYL-1-M-TOLYL-1H-PYRAZOL-5-AMINE
- DS-6418
- EN300-37345
- SCHEMBL1013681
- J-513108
- 3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine
-
- MDL： MFCD04115069
- Inchi： 1S/C14H19N3/c1-10-6-5-7-11(8-10)17-13(15)9-12(16-17)14(2,3)4/h5-9H,15H2,1-4H3
- InChI Key： YDYDGSYHOOCUPO-UHFFFAOYSA-N
- SMILES： N1N(C2C=C(C)C=CC=2)C(N)=CC=1C(C)(C)C
Computed Properties
- Exact Mass: 229.15800
- Monoisotopic Mass: 229.157897619g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 17
- Rotatable Bond Count: 2
- Complexity: 259
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 43.8
- XLogP3: 3.6
Experimental Properties
- Density: 1.1±0.1 g/cm3
- Melting Point: 90-92 °CEnamineEN300-37345
- Boiling Point: 378.1±37.0 °C at 760 mmHg
- Flash Point: 182.5±26.5 °C
- PSA: 43.84000
- LogP: 3.64160
- Vapor Pressure: 0.0±0.9 mmHg at 25°C
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Security Information
- Signal Word：warning
- Hazard Statement： H303+H313+H333
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Customs Data
- HS CODE：2933199090
- Customs Data：
China Customs Code:
2933199090Overview:
2933199090. Other structurally non fused pyrazole ring compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-RI773-5g |
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine |
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| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-RI773-250mg |
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| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-RI773-50mg |
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| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 68R0001-1g |
5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-ylamine |
898537-77-4 | 97% | 1g |
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| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 68R0001-5g |
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898537-77-4 | 97% | 25g |
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898537-77-4 | 97% | 500mg |
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5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-ylamine |
898537-77-4 | 97% | 250mg |
924.37CNY | 2021-05-08 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 68R0001-100mg |
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3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Production Method
Production Method 1
Reaction Conditions
1.1 Catalysts: Acetic acid Solvents: Ethanol ; overnight, reflux
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol ; 6 - 8 h, 80 °C
Reference
- Synthesis and p38 inhibitory activity of some novel substituted N,N'-diarylurea derivativesZhu, Dianxi; Xing, Qifeng; Cao, Ruiyuan; Zhao, Dongmei; Zhong, Wu, Molecules, 2016, 21(5), 677/1-677/27
Production Method 3
Reaction Conditions
1.1 Solvents: Ethanol ; 12 - 14 h, reflux
Reference
- Synthesis of new pyrazolyl urea derivatives as antiinflammatory agentsRadhika, K.; Tangeda, Saritha Jyostna; Garlapati, Achaiah, Indian Journal of Heterocyclic Chemistry, 2012, 22(2), 155-158
Production Method 4
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol ; 48 h, reflux; reflux → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 10 - 11, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 10 - 11, rt
Reference
- Synthesis and biological evaluation of chromenylurea and chromanylurea derivatives as anti-TNF-α agents that target the p38 MAPK pathwayLi, Xingzhou; Zhou, Xinming; Zhang, Jing; Wang, Lili; Long, Long; et al, Molecules, 2014, 19(2), 2004-2028
Production Method 5
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 24 h, 90 °C
Reference
- Development of a Fluorescent-Tagged Kinase Assay System for the Detection and Characterization of Allosteric Kinase InhibitorsSimard, Jeffrey R.; Getlik, Matthaus; Grutter, Christian; Pawar, Vijaykumar; Wulfert, Sabine; et al, Journal of the American Chemical Society, 2009, 131(37), 13286-13296
Production Method 6
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water ; 24 h, 90 °C
Reference
- Hybrid Compound Design To Overcome the Gatekeeper T338M Mutation in cSrcGetlik, Matthaeus; Gruetter, Christian; Simard, Jeffrey R.; Kluter, Sabine; Rabiller, Matthias; et al, Journal of Medicinal Chemistry, 2009, 52(13), 3915-3926
Production Method 7
Reaction Conditions
1.1 Catalysts: Acetic acid Solvents: Ethanol ; overnight, reflux
Reference
- Synthesis, Antibacterial, Antifungal and Antitubercular Activities of N-Pyrazolylbenzamide DerivativesKulkarni, Ravindra; Vijaykumar; Babu, Harish; Kumar, Krishna; Gaddam, Naveen; et al, Medicinal Chemistry (Sharjah, 2014, 10(2), 220-227
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Raw materials
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Preparation Products
3-(Tert-Butyl)-1-(m-tolyl)-1H-pyrazol-5-amine Related Literature
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Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
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