- Synthesis of kainoid analogsBarraclough, Paul; Hudhomme, Pietrick; Spray, Caroline A.; Young, Douglas W., Tetrahedron, 1995, 51(14), 4195-212
Cas no 89813-47-8 (2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate)
89813-47-8 structure
Product Name:2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
CAS No:89813-47-8
MF:C17H23NO5
MW:321.368225336075
MDL:MFCD00076979
CID:588418
PubChem ID:11902907
Update Time:2024-10-26
2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Chemical and Physical Properties
Names and Identifiers
-
- 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl)2-(phenylmethyl) ester, (2S,4R)-
- BOC-HYP-OBZL
- Boc-O-Hyp-OBzl
- Boc-trans-L-4-hydroxyproline benzyl ester
- N-Boc-trans-4-hydroxy-L-proline benzyl ester
- (2S,4R)-4-Hydroxy-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester
- 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2S-trans)- (ZCI)
- 1-(1,1-Dimethylethyl) 2-(phenylmethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate (ACI)
- N-(tert-Butoxycarbonyl)-4-hydroxyproline benzyl ester
- 2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
- 89813-47-8
- XH0429
- MFCD00076979
- BEIPCYKSYYZEJH-KGLIPLIRSA-N
- SCHEMBL1150829
- (2s,4r)-2-benzyl 1-t-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- AS-49203
- 2-O-benzyl 1-O-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
- 2-Benzyl 1-(tert-butyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate
- (2S,4R)-2-Benzyl1-tert-butyl4-hydroxypyrrolidine-1,2-dicarboxylate
- CS-0159086
- AKOS015895923
- 2-Benzyl 1-(tert-butyl) (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
- AKOS015836548
- FD21790
- Benzyl (4R)-1-Boc-4-hydroxy-L-prolinate
- BocHypOBn
- Boc-Hyp-OBn
- (2S,4R)-2-Benzyl 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate
-
- MDL： MFCD00076979
- Inchi： 1S/C17H23NO5/c1-17(2,3)23-16(21)18-10-13(19)9-14(18)15(20)22-11-12-7-5-4-6-8-12/h4-8,13-14,19H,9-11H2,1-3H3/t13-,14+/m1/s1
- InChI Key： BEIPCYKSYYZEJH-KGLIPLIRSA-N
- SMILES： C(N1C[C@H](O)C[C@H]1C(=O)OCC1C=CC=CC=1)(=O)OC(C)(C)C
Computed Properties
- Exact Mass: 321.15800
- Monoisotopic Mass: 321.15762283g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 23
- Rotatable Bond Count: 7
- Complexity: 425
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.1
- Topological Polar Surface Area: 76.1?2
Experimental Properties
- Density: 1.225
- PSA: 76.07000
- LogP: 2.03800
2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM198963-5g |
2-benzyl 1-(tert-butyl) (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate |
89813-47-8 | 97% | 5g |
$547 | 2021-06-09 | |
| Chemenu | CM198963-10g |
2-benzyl 1-(tert-butyl) (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate |
89813-47-8 | 97% | 10g |
$1040 | 2021-06-09 | |
| Chemenu | CM198963-25g |
2-benzyl 1-(tert-butyl) (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate |
89813-47-8 | 97% | 25g |
$2174 | 2021-06-09 | |
| TRC | B600635-100mg |
Boc-hyp-obzl |
89813-47-8 | 100mg |
$ 110.00 | 2023-04-18 | ||
| TRC | B600635-250mg |
Boc-hyp-obzl |
89813-47-8 | 250mg |
$ 207.00 | 2023-04-18 | ||
| TRC | B600635-500mg |
Boc-hyp-obzl |
89813-47-8 | 500mg |
$ 328.00 | 2023-04-18 | ||
| TRC | B600635-1g |
Boc-hyp-obzl |
89813-47-8 | 1g |
$ 460.00 | 2023-04-18 | ||
| eNovation Chemicals LLC | D510818-25g |
N-Boc-trans-4-hydroxy-L-proline benzyl ester |
89813-47-8 | >95% | 25g |
$1150 | 2025-02-20 | |
| eNovation Chemicals LLC | D510818-50g |
N-Boc-trans-4-hydroxy-L-proline benzyl ester |
89813-47-8 | >95% | 50g |
$1650 | 2025-02-20 | |
| eNovation Chemicals LLC | Y1197920-5g |
Benzyl (2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate |
89813-47-8 | 95% | 5g |
$890 | 2025-02-20 |
2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Cesium carbonate Solvents: Methanol , Water
1.2 Solvents: Dimethylformamide
1.2 Solvents: Dimethylformamide
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; overnight, rt
Reference
- Design and synthesis of plant cyclopeptide Astin C analogs and investigation of their immunosuppressive activityLi, Fei; Guo, Xi-Xi; Zeng, Guang-Zhi; Qin, Wei-Wei; Zhang, Bo; et al, Bioorganic & Medicinal Chemistry Letters, 2018, 28(14), 2523-2527
Production Method 3
Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Acetonitrile , Water
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide
Reference
- Novel sulfur and selenium containing bis-α-amino acids from 4-hydroxyprolineCaputo, Romualdo; Della Greca, Marina; de Paola, Ivan; Mastroianni, Domenico; Longobardo, Luigi, Amino Acids, 2010, 38(1), 305-310
Production Method 4
Reaction Conditions
1.1 Reagents: Cesium carbonate Solvents: Methanol , Water ; 0 °C
1.2 Solvents: Dimethylformamide ; 12 h, 0 °C
1.2 Solvents: Dimethylformamide ; 12 h, 0 °C
Reference
- Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple HelixShoulders, Matthew D.; Raines, Ronald T., Journal of Biological Chemistry, 2011, 286(26), 22905-22912
Production Method 5
Reaction Conditions
1.1 Reagents: Cesium carbonate Solvents: Methanol , Water ; rt → 0 °C
1.2 Solvents: Dimethylformamide ; 0 °C; 20 h, rt
1.2 Solvents: Dimethylformamide ; 0 °C; 20 h, rt
Reference
- Discovery of subnanomolar arginine-glycine-aspartate-based αVβ3/αVβ5 integrin binders embedding 4-aminoproline residuesZanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; et al, Journal of Medicinal Chemistry, 2008, 51(6), 1771-1782
2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Raw materials
2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Preparation Products
2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Related Literature
-
Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
-
Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
-
Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636
-
Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
-
Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
89813-47-8 (2-benzyl 1-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate) Related Products
- 13504-85-3((2S,4R)-1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid)
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- 71170-89-3(1,2-Piperidinedicarboxylicacid, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester)
- 16881-39-3(N-Carbobenzoxy-l-proline tert-butyl ester)
- 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
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- 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
- 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
- 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
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