Production Method 1

5751-82-6

89640-03-9

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  3 h, 0 °C
1.2 Solvents: Water ;  0 °C

Reference

Design, synthesis, and biological evaluation of novel 3-(thiophen-2-ylthio)pyridine derivatives as potential multitarget anticancer agents

Xi, Jian-Jun ; He, Ruo-Yu; Zhang, Jian-Kang; Cai, Zhao-Bin; Zhuang, Rang-Xiao; et al, Archiv der Pharmazie (Weinheim, 2019, 352(8),

Ethyl 5-chloro-4-nitrothiophene-2-carboxylate Raw materials

• Ethyl 5-chlorothiophene-2-carboxylate

Ethyl 5-chloro-4-nitrothiophene-2-carboxylate Preparation Products

• Ethyl 5-chloro-4-nitrothiophene-2-carboxylate (89640-03-9)

• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 3. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 5. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Nitrothiophenes 3-nitrothiophenes

Comprehensive Overview of Ethyl 5-chloro-4-nitrothiophene-2-carboxylate (CAS No. 89640-03-9)

Ethyl 5-chloro-4-nitrothiophene-2-carboxylate (CAS No. 89640-03-9) is a specialized organic compound widely utilized in pharmaceutical and agrochemical research. This thiophene derivative is recognized for its unique structural properties, making it a valuable intermediate in synthetic chemistry. Researchers often explore its applications in developing novel heterocyclic compounds, which are pivotal in drug discovery and material science.

The compound's molecular structure features a chloro and nitro substitution on the thiophene ring, enhancing its reactivity and versatility. Its ethyl carboxylate moiety further contributes to its solubility and functionalization potential. These attributes have sparked interest in its use for designing bioactive molecules, particularly in addressing challenges related to antimicrobial resistance and crop protection, two trending topics in scientific communities.

In recent years, the demand for Ethyl 5-chloro-4-nitrothiophene-2-carboxylate has grown due to its role in synthesizing small-molecule inhibitors and polymer precursors. Its relevance in green chemistry initiatives has also been noted, as researchers seek eco-friendly pathways for its production. Questions like "How to optimize the synthesis of Ethyl 5-chloro-4-nitrothiophene-2-carboxylate?" or "What are its applications in medicinal chemistry?" frequently appear in academic searches, reflecting its interdisciplinary importance.

From a technical perspective, the compound's CAS No. 89640-03-9 serves as a critical identifier for regulatory and safety documentation. Its thermal stability and compatibility with common solvents make it suitable for lab-scale and industrial applications. However, handling requires adherence to standard protocols, as with any nitroaromatic compound. Discussions on platforms like ResearchGate often highlight its potential in catalysis and material functionalization, aligning with the broader interest in sustainable chemical processes.

Innovations in crystal engineering have further expanded the utility of Ethyl 5-chloro-4-nitrothiophene-2-carboxylate. Studies focus on its supramolecular interactions to design advanced materials with tailored properties. This aligns with the rising popularity of keywords such as "smart materials" and "molecular design" in scientific literature. The compound's adaptability underscores its role in bridging gaps between organic synthesis and applied sciences.

In summary, Ethyl 5-chloro-4-nitrothiophene-2-carboxylate (CAS No. 89640-03-9) exemplifies the synergy between fundamental research and practical innovation. Its multifaceted applications—from pharmaceutical intermediates to functional materials—make it a compound of enduring relevance. As scientific inquiries evolve, its study will likely remain at the forefront of chemical research, answering pressing questions in healthcare and technology.

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